Submissions for variant NM_058216.3(RAD51C):c.102T>G (p.Thr34=)

gnomAD frequency: 0.00001  dbSNP: rs550757849

Total submissions: 6

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000425908	SCV000533610	likely benign	not specified	2016-11-01	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics	RCV000574635	SCV000663763	likely benign	Hereditary cancer-predisposing syndrome	2015-10-02	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Color Diagnostics, LLC DBA Color Health	RCV000574635	SCV000691215	likely benign	Hereditary cancer-predisposing syndrome	2017-08-26	criteria provided, single submitter	clinical testing
Invitae	RCV000874162	SCV001016295	likely benign	Fanconi anemia complementation group O	2024-01-26	criteria provided, single submitter	clinical testing
Genetic Services Laboratory, University of Chicago	RCV000425908	SCV002065403	likely benign	not specified	2021-06-11	criteria provided, single submitter	clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano	RCV003477933	SCV004220130	likely benign	not provided	2023-04-07	criteria provided, single submitter	clinical testing