Submissions for variant NM_058216.3(RAD51C):c.146-3C>T

gnomAD frequency: 0.00002  dbSNP: rs765143155

Total submissions: 5

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Labcorp Genetics (formerly Invitae), Labcorp	RCV000473377	SCV000550191	likely benign	Fanconi anemia complementation group O	2024-09-18	criteria provided, single submitter	clinical testing
Mendelics	RCV000473377	SCV001140712	likely benign	Fanconi anemia complementation group O	2019-05-28	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV001011704	SCV001172057	likely benign	Hereditary cancer-predisposing syndrome	2019-09-27	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Color Diagnostics, LLC DBA Color Health	RCV001011704	SCV001348040	likely benign	Hereditary cancer-predisposing syndrome	2021-05-18	criteria provided, single submitter	clinical testing
CeGaT Center for Human Genetics Tuebingen	RCV003221990	SCV003917953	likely benign	not provided	2023-03-01	criteria provided, single submitter	clinical testing	RAD51C: BP4