Total submissions: 7
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Invitae | RCV001087739 | SCV000291217 | likely benign | Fanconi anemia complementation group O | 2024-01-07 | criteria provided, single submitter | clinical testing | |
Gene |
RCV000766483 | SCV000294044 | uncertain significance | not provided | 2022-11-02 | criteria provided, single submitter | clinical testing | Has not been previously published as pathogenic or benign to our knowledge; In silico analysis supports that this variant does not alter splicing |
Quest Diagnostics Nichols Institute San Juan Capistrano | RCV000766483 | SCV000602138 | uncertain significance | not provided | 2022-09-23 | criteria provided, single submitter | clinical testing | To the best of our knowledge, the variant has not been reported in the published literature. The frequency of this variant in the general population, 0.00044 (11/24966 chromosomes, http://gnomad.broadinstitute.org), is uninformative in assessment of its pathogenicity. Analysis of this variant using software algorithms for the prediction of the effect of nucleotide changes on splicing yielded predictions that this variant does not affect RAD51C mRNA splicing . Based on the available information, we are unable to determine the clinical significance of this variant. |
Ambry Genetics | RCV000575965 | SCV000663760 | likely benign | Hereditary cancer-predisposing syndrome | 2015-05-15 | criteria provided, single submitter | clinical testing | This alteration is classified as likely benign based on a combination of the following: population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity. |
Color Diagnostics, |
RCV000575965 | SCV000911186 | likely benign | Hereditary cancer-predisposing syndrome | 2015-11-16 | criteria provided, single submitter | clinical testing | |
Institute for Biomarker Research, |
RCV003315240 | SCV004014961 | likely benign | Hereditary breast ovarian cancer syndrome | 2023-04-11 | criteria provided, single submitter | clinical testing | |
Prevention |
RCV003897566 | SCV004710005 | likely benign | RAD51C-related condition | 2021-11-04 | criteria provided, single submitter | clinical testing | This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications). |