ClinVar Miner

Submissions for variant NM_058216.3(RAD51C):c.399dup (p.Leu134fs)

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Baylor Genetics RCV003463443 SCV004208031 likely pathogenic Breast-ovarian cancer, familial, susceptibility to, 3 2022-09-01 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV003463443 SCV004932347 pathogenic Breast-ovarian cancer, familial, susceptibility to, 3 2024-01-02 criteria provided, single submitter clinical testing This variant is considered pathogenic. This variant creates a frameshift predicted to result in premature protein truncation.

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