Submissions for variant NM_058216.3(RAD51C):c.453G>A (p.Val151=)

gnomAD frequency: 0.00002  dbSNP: rs45553636

Total submissions: 6

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000589704	SCV000515478	likely benign	not provided	2020-01-25	criteria provided, single submitter	clinical testing	This variant is associated with the following publications: (PMID: 21537932)
Ambry Genetics	RCV000568149	SCV000663753	likely benign	Hereditary cancer-predisposing syndrome	2017-04-13	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Color Diagnostics, LLC DBA Color Health	RCV000568149	SCV000686354	likely benign	Hereditary cancer-predisposing syndrome	2017-01-24	criteria provided, single submitter	clinical testing
Women's Health and Genetics/Laboratory Corporation of America, LabCorp	RCV000443166	SCV000699810	likely benign	not specified	2019-08-29	criteria provided, single submitter	clinical testing
Invitae	RCV001089442	SCV000770085	likely benign	Fanconi anemia complementation group O	2024-01-31	criteria provided, single submitter	clinical testing
PreventionGenetics, part of Exact Sciences	RCV000589704	SCV000807170	likely benign	not provided	2017-10-11	criteria provided, single submitter	clinical testing