ClinVar Miner

Submissions for variant NM_058216.3(RAD51C):c.459T>G (p.Gly153=)

dbSNP: rs769486350
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000162528 SCV000212925 likely benign Hereditary cancer-predisposing syndrome 2015-11-17 criteria provided, single submitter clinical testing This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Counsyl RCV000412114 SCV000489889 benign Fanconi anemia complementation group O 2016-07-11 criteria provided, single submitter clinical testing
Counsyl RCV000409708 SCV000489890 benign Breast-ovarian cancer, familial, susceptibility to, 3 2016-07-11 criteria provided, single submitter clinical testing

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