Submissions for variant NM_058216.3(RAD51C):c.571+16A>G

gnomAD frequency: 0.00034  dbSNP: rs141621051

Total submissions: 8

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Counsyl	RCV000412026	SCV000490009	likely benign	Fanconi anemia complementation group O	2016-09-20	criteria provided, single submitter	clinical testing
Counsyl	RCV000409575	SCV000490010	likely benign	Breast-ovarian cancer, familial, susceptibility to, 3	2016-09-20	criteria provided, single submitter	clinical testing
GeneDx	RCV000424810	SCV000516773	benign	not specified	2015-05-18	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color Diagnostics, LLC DBA Color Health	RCV000580412	SCV000686362	likely benign	Hereditary cancer-predisposing syndrome	2016-04-20	criteria provided, single submitter	clinical testing
PreventionGenetics, part of Exact Sciences	RCV000679800	SCV000807173	likely benign	not provided	2016-10-03	criteria provided, single submitter	clinical testing
Labcorp Genetics (formerly Invitae), Labcorp	RCV000412026	SCV002444679	likely benign	Fanconi anemia complementation group O	2025-02-04	criteria provided, single submitter	clinical testing
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario	RCV003150196	SCV003838370	likely benign	Breast and/or ovarian cancer	2023-04-25	criteria provided, single submitter	clinical testing
KCCC/NGS Laboratory, Kuwait Cancer Control Center	RCV000409575	SCV005881173	benign	Breast-ovarian cancer, familial, susceptibility to, 3	2025-02-01	criteria provided, single submitter	clinical testing