Submissions for variant NM_058216.3(RAD51C):c.572-17G>T

gnomAD frequency: 0.00513  dbSNP: rs193023469

Total submissions: 20

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000212942	SCV000171265	benign	not specified	2013-10-23	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
PreventionGenetics, part of Exact Sciences	RCV000212942	SCV000315332	likely benign	not specified		criteria provided, single submitter	clinical testing
Color Diagnostics, LLC DBA Color Health	RCV000127686	SCV000686363	likely benign	Hereditary cancer-predisposing syndrome	2015-04-03	criteria provided, single submitter	clinical testing
Mendelics	RCV000989961	SCV001140717	likely benign	Fanconi anemia complementation group O	2019-05-28	criteria provided, single submitter	clinical testing
Institute of Human Genetics, University of Leipzig Medical Center	RCV001262197	SCV001439982	likely benign	Breast-ovarian cancer, familial, susceptibility to, 3	2019-01-01	criteria provided, single submitter	clinical testing	This variant was identified as compound heterozygous.
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories	RCV000679801	SCV001474144	benign	not provided	2023-10-09	criteria provided, single submitter	clinical testing
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden	RCV000679801	SCV002010650	likely benign	not provided	2021-11-03	criteria provided, single submitter	clinical testing
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario	RCV001798427	SCV002043690	benign	Breast and/or ovarian cancer	2023-02-09	criteria provided, single submitter	clinical testing
Invitae	RCV000989961	SCV002424701	benign	Fanconi anemia complementation group O	2024-02-01	criteria provided, single submitter	clinical testing
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital	RCV000212942	SCV002551134	likely benign	not specified	2023-08-15	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV000127686	SCV002650635	likely benign	Hereditary cancer-predisposing syndrome	2015-06-30	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Fulgent Genetics, Fulgent Genetics	RCV002498629	SCV002813195	likely benign	Breast-ovarian cancer, familial, susceptibility to, 3; Fanconi anemia complementation group O	2021-08-04	criteria provided, single submitter	clinical testing
CeGaT Center for Human Genetics Tuebingen	RCV000679801	SCV003917955	likely benign	not provided	2023-05-01	criteria provided, single submitter	clinical testing	RAD51C: BS2
KCCC/NGS Laboratory, Kuwait Cancer Control Center	RCV001262197	SCV004017246	benign	Breast-ovarian cancer, familial, susceptibility to, 3	2023-07-07	criteria provided, single submitter	clinical testing
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center	RCV001262197	SCV004805809	benign	Breast-ovarian cancer, familial, susceptibility to, 3	2024-03-29	criteria provided, single submitter	clinical testing
University of Washington Department of Laboratory Medicine, University of Washington	RCV000127686	SCV000265441	likely benign	Hereditary cancer-predisposing syndrome	2015-12-01	no assertion criteria provided	clinical testing
Genome Diagnostics Laboratory, Amsterdam University Medical Center	RCV000212942	SCV001808682	benign	not specified		no assertion criteria provided	clinical testing
Clinical Genetics Laboratory, Department of Pathology, Netherlands Cancer Institute	RCV000679801	SCV001906071	likely benign	not provided		no assertion criteria provided	clinical testing
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+	RCV000679801	SCV001959140	likely benign	not provided		no assertion criteria provided	clinical testing
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC)	RCV000679801	SCV002035934	likely benign	not provided		no assertion criteria provided	clinical testing