ClinVar Miner

Submissions for variant NM_058216.3(RAD51C):c.837+1G>A (rs760235677)

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000221081 SCV000273205 pathogenic Hereditary cancer-predisposing syndrome 2015-03-03 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Other acmg-defined mutation (i.e. initiation codon or gross deletion),Alterations at the canonical donor/acceptor sites (+/- 1, 2) without other strong (b-level) evidence supporting pathogenicity
OMIM RCV000024267 SCV000045558 risk factor Breast-ovarian cancer, familial 3 2011-08-15 no assertion criteria provided literature only

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