ClinVar Miner

Submissions for variant NM_058216.3(RAD51C):c.905-20A>G

dbSNP: rs950351911
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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000606113 SCV000718402 likely benign not specified 2017-04-12 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color Diagnostics, LLC DBA Color Health RCV001190492 SCV001357993 likely benign Hereditary cancer-predisposing syndrome 2019-06-04 criteria provided, single submitter clinical testing
Labcorp Genetics (formerly Invitae), Labcorp RCV002063145 SCV002439928 likely benign Fanconi anemia complementation group O 2025-01-16 criteria provided, single submitter clinical testing
Fulgent Genetics, Fulgent Genetics RCV002498917 SCV002804887 likely benign Breast-ovarian cancer, familial, susceptibility to, 3; Fanconi anemia complementation group O 2022-04-13 criteria provided, single submitter clinical testing
Ambry Genetics RCV001190492 SCV004849258 uncertain significance Hereditary cancer-predisposing syndrome 2015-12-06 criteria provided, single submitter clinical testing The c.905-20A>G intronic alteration consists of a A to G substitution 20 nucleotides before coding exon 7 in the RAD51C gene. Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear.

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