Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Molecular Genetics, |
RCV002225239 | SCV002503847 | uncertain significance | Malignant hyperthermia of anesthesia | 2021-02-26 | criteria provided, single submitter | clinical testing | This sequence change is predicted to replace arginine with histidine at codon 722 of the TRPV1 protein (p.(Arg722His)). The arginine residue is highly conserved (100 vertebrates, UCSC), and is located in the ion transport domain. There is a small physicochemical difference between arginine and histidine. The variant is present in a large population cohort at a frequency of 0.003% (rs771123129, 9/278,882 alleles, 0 homozygotes in gnomAD v2.1), with a frequency of 0.009% in the Latino/admixed American population (3/35,164 alleles in gnomAD v2.1). The variant has not been reported in the relevant medical literature or databases. Multiple lines of computational evidence predict a deleterious effect for the missense substitution (4/4 algorithms). Based on the classification scheme RMH Modified ACMG Guidelines v1.3.1, this variant is classified as a VARIANT OF UNCERTAIN SIGNIFICANCE. Following criteria are met: PP3. |