Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Pediatric Genomics Discovery Program, |
RCV000845245 | SCV000967800 | likely pathogenic | Cardiospondylocarpofacial syndrome | 2019-08-23 | criteria provided, single submitter | research | The p.Val42del variant is closely situated to other variants associated with CSCFS, p.Arg44_Gly45del, and p.Val50del (Le Goff 2016). The p.Val42del variant is likely pathogenic due to its de novo status (PS2) and its absence from control individuals (PM2). However, additional evidence supporting pathogenicity is that this single amino acid inframe deletion is not located within a repetitive region and thus does change the length of the protein to a small extent. The disease may be too rare and considerably overlaps with other disorders; thus it is inaccurate to say the patient phenotype in this case is highly specific for CSCFS, though the patient with this variant does have key features. Additionally, while this is not a missense change, the MAP3K7 gene does feature a relatively low tolerance to missense change, and we could extrapolate that indels may also be poorly tolerated in the gene given their specific recurrence in CSCFS. |