ClinVar Miner

Submissions for variant NM_177438.3(DICER1):c.5527+7T>C

dbSNP: rs375239471
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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV000902320 SCV001046737 likely benign DICER1-related tumor predisposition 2024-04-24 criteria provided, single submitter clinical testing
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital RCV004596369 SCV005090126 likely benign not specified 2025-03-04 criteria provided, single submitter clinical testing
Hereditary Cancer Group, L’Institut d'Investigació Biomèdica de Bellvitge RCV004821292 SCV005442398 likely benign Hereditary cancer-predisposing syndrome 2024-12-19 criteria provided, single submitter clinical testing BP4, BP7
PreventionGenetics, part of Exact Sciences RCV003975745 SCV004792788 likely benign DICER1-related disorder 2022-01-26 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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