Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
New York Genome Center | RCV001839147 | SCV002099073 | uncertain significance | SHORT syndrome; Immunodeficiency 36 | 2021-03-12 | criteria provided, single submitter | clinical testing | The inherited, deep intronic c.917-4792G>A variant identified in the PIK3R1 gene substitutes a Guanine for Adenine within intron 7/15. The Guanine at this position is only moderately conserved in vertebrates, and several vertebrate species have an Adenine at this position. This variant is found with low frequency in gnomAD(v3.1) (1 heterozygote, 0 homozygotes; allele frequency: 6.57e-6), suggesting it is not a common benign variant in the populations represented in that database. While SpliceAI does not predict that this variant will lead to an alteration of splicing, the Transcript inferred Pathogenicity (TraP) score for this variant is 0.284, which is between 95-97.5% (score-percentile) suggesting it is probably damaging to splicing. This variant has not been reported in ClinVar and to our current knowledge has not been reported in affected individuals in the literature. Given the lack of compelling evidence for its pathogenicity, the inherited, deep intronic c.917-4792G>A variant identified in the PIK3R1 gene is reported as a Variant of Uncertain Significance. |