Submissions for variant NM_181741.4(ORC4):c.233A>G (p.Asn78Ser)

gnomAD frequency: 0.32301  dbSNP: rs2307394

Total submissions: 8

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
PreventionGenetics, part of Exact Sciences	RCV000146999	SCV000309113	benign	not specified		criteria provided, single submitter	clinical testing
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine	RCV000146999	SCV000539980	benign	not specified	2016-03-28	criteria provided, single submitter	clinical testing	Variant identified in a genome or exome case(s) and assessed due to predicted null impact of the variant or pathogenic assertions in the literature or databases. Disclaimer: This variant has not undergone full assessment. The following are preliminary notes: MAF
Mendelics	RCV000986824	SCV001135961	benign	Meier-Gorlin syndrome 2	2019-05-28	criteria provided, single submitter	clinical testing
Labcorp Genetics (formerly Invitae), Labcorp	RCV001511200	SCV001718403	benign	not provided	2025-02-03	criteria provided, single submitter	clinical testing
GeneDx	RCV001511200	SCV001901284	benign	not provided	2018-07-09	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV000986824	SCV002029314	benign	Meier-Gorlin syndrome 2	2021-09-05	criteria provided, single submitter	clinical testing
Breakthrough Genomics, Breakthrough Genomics	RCV001511200	SCV005245397	benign	not provided		criteria provided, single submitter	not provided
Genetic Services Laboratory, University of Chicago	RCV000146999	SCV000194336	likely benign	not specified		no assertion criteria provided	clinical testing