Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Neuberg Centre For Genomic Medicine, |
RCV001823690 | SCV002073317 | uncertain significance | Emery-Dreifuss muscular dystrophy 5, autosomal dominant | criteria provided, single submitter | clinical testing | The missense variant p.C6762R in SYNE2 (NM_182914.3) has not been reported previously as a pathogenic variant nor as a benign variant, to our knowledge. The p.C6762R variant is novel (not in any individuals) in gnomAD Exomes and is novel (not in any individuals) in 1000 Genomes. There is a large physicochemical difference between cysteine and arginine, which is likely to impact secondary protein structure as these residues differ in polarity, charge, size and/or other properties. In silico tools are contradictory in their predictions (SIFT-damaging, Polyphen-2-tolerated) and the residue is conserved across species. For these reasons, this variant has been classified as Uncertain Significance. |