Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Breakthrough Genomics, |
RCV004596694 | SCV005088844 | pathogenic | Congenital myasthenic syndrome 8 | 2020-09-12 | criteria provided, single submitter | clinical testing | This variant is predicted to cause a premature termination of the protein and the resultant protein is likely to lack all functional domain of the protein such as: Kazal domain, Laminin G domain, SEA domain and EGF-like domain [UniProt]; this will likely result in loss-of-function. Due to the introduction of a premature stop codon, this aberrant transcript will likely be targeted by the nonsense-mediated mRNA decay (NMD) mechanism [PMID: 15040442]. The variant seems to be a novel variant, as it has not been previously reported in population databases or in the literature. However, several other nonsense variants lying downstream of the variant, have been previously reported as ‘pathogenic’ in the ClinVar database context of congenital myasthenic syndrome. Loss-of-function variants in the gene are known to be pathogenic [PMID: 24951643]. |