ClinVar Miner

Submissions for variant NM_198578.4(LRRK2):c.2525T>G (p.Met842Arg)

Minimum review status: Collection method:
Minimum conflict level:
ClinVar version:
Total submissions: 1
Download table as spreadsheet
Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV004645011 SCV005132886 uncertain significance Inborn genetic diseases 2024-04-26 criteria provided, single submitter clinical testing The p.M842R variant (also known as c.2525T>G), located in coding exon 20 of the LRRK2 gene, results from a T to G substitution at nucleotide position 2525. The methionine at codon 842 is replaced by arginine, an amino acid with similar properties. This amino acid position is conserved. In addition, the in silico prediction for this alteration is inconclusive. Based on the available evidence, the clinical significance of this variant remains unclear.

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.