ClinVar Miner

Submissions for variant NM_198578.4(LRRK2):c.4230G>A (p.Thr1410=)

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV002328120 SCV002632802 likely benign Inborn genetic diseases 2022-02-28 criteria provided, single submitter clinical testing This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Labcorp Genetics (formerly Invitae), Labcorp RCV003638833 SCV004431316 likely benign Autosomal dominant Parkinson disease 8 2023-02-27 criteria provided, single submitter clinical testing

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