ClinVar Miner

Submissions for variant NM_201384.3(PLEC):c.9004C>T (p.Arg3002Ter)

dbSNP: rs137853161
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV001851744 SCV002241323 pathogenic Epidermolysis bullosa simplex 5B, with muscular dystrophy; Epidermolysis bullosa simplex, Ogna type; Epidermolysis bullosa simplex 5C, with pyloric atresia; Autosomal recessive limb-girdle muscular dystrophy type 2Q; Epidermolysis bullosa simplex with nail dystrophy 2020-11-03 criteria provided, single submitter clinical testing For these reasons, this variant has been classified as Pathogenic. This variant disrupts the C-terminus of the PLEC protein. Other variant(s) that disrupt this region (p.Ser4396*) have been determined to be pathogenic (Invitae). This suggests that variants that disrupt this region of the protein are likely to be causative of disease. Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may create or strengthen a splice site, but this prediction has not been confirmed by published transcriptional studies. This variant has been observed in individual(s) with autosomal recessive epidermolysis bullosa (PMID: 15654962). ClinVar contains an entry for this variant (Variation ID: 8266). This variant is not present in population databases (ExAC no frequency). This sequence change creates a premature translational stop signal (p.Arg3029*) in the PLEC gene. While this is not anticipated to result in nonsense mediated decay, it is expected to disrupt the last 1546 amino acid(s) of the PLEC protein.
OMIM RCV000008755 SCV000028964 pathogenic Epidermolysis bullosa simplex 5C, with pyloric atresia 2005-01-01 no assertion criteria provided literature only

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