Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Ambry Genetics | RCV004460887 | SCV004958011 | uncertain significance | not specified | 2024-03-07 | criteria provided, single submitter | clinical testing | The c.3872C>T (p.T1291I) alteration is located in exon 25 (coding exon 25) of the SSPO gene. This alteration results from a C to T substitution at nucleotide position 3872, causing the threonine (T) at amino acid position 1291 to be replaced by an isoleucine (I). Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear. |