ClinVar Miner

Submissions for variant UGT1A1*36

dbSNP: rs3064744
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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories RCV001515198 SCV000605523 benign not provided 2023-11-27 criteria provided, single submitter clinical testing
Medical Genetics Summaries RCV000664406 SCV000788338 drug response Irinotecan response 2018-04-04 criteria provided, single submitter curation UGT1A1*36 is not associated with irinotecan toxicity. This variant is associated with increased promoter activity and a reduced risk of neonatal hyperbilirubinemia.
Labcorp Genetics (formerly Invitae), Labcorp RCV001515198 SCV001723217 benign not provided 2020-10-19 criteria provided, single submitter clinical testing
GeneDx RCV001515198 SCV001937662 benign not provided 2018-07-15 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003965423 SCV004791887 benign UGT1A9-related disorder 2022-07-11 no assertion criteria provided clinical testing This variant is classified as benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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