List of variants in gene MSH6 reported as uncertain significance for Breast and/or ovarian cancer

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 41

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HGVS	dbSNP	gnomAD frequency
NM_000179.3(MSH6):c.3488A>T (p.Glu1163Val)	rs63750252	0.00032
NM_000179.3(MSH6):c.2398G>C (p.Val800Leu)	rs61748083	0.00014
NM_000179.3(MSH6):c.2384T>C (p.Ile795Thr)	rs202127474	0.00007
NM_000179.3(MSH6):c.3283C>T (p.Arg1095Cys)	rs376243329	0.00006
NM_000179.3(MSH6):c.1844G>C (p.Cys615Ser)	rs730881793	0.00005
NM_000179.3(MSH6):c.2173A>G (p.Ile725Val)	rs148898662	0.00005
NM_000179.3(MSH6):c.107C>T (p.Ala36Val)	rs61756469	0.00004
NM_000179.3(MSH6):c.1937A>G (p.Lys646Arg)	rs201096652	0.00004
NM_000179.3(MSH6):c.749T>C (p.Val250Ala)	rs587781275	0.00004
NM_000179.3(MSH6):c.-2G>T	rs374748889	0.00003
NM_000179.3(MSH6):c.362G>A (p.Arg121His)	rs769279475	0.00003
NM_000179.3(MSH6):c.3740C>G (p.Thr1247Ser)	rs786204182	0.00002
NM_000179.3(MSH6):c.3851C>T (p.Thr1284Met)	rs63750836	0.00002
NM_000179.3(MSH6):c.899G>A (p.Arg300Gln)	rs55760494	0.00002
NM_000179.3(MSH6):c.1061G>T (p.Gly354Val)	rs730881788	0.00001
NM_000179.3(MSH6):c.1599G>C (p.Glu533Asp)	rs373726731	0.00001
NM_000179.3(MSH6):c.161G>C (p.Gly54Ala)	rs63751098	0.00001
NM_000179.3(MSH6):c.2175C>G (p.Ile725Met)	rs63750304	0.00001
NM_000179.3(MSH6):c.2603T>C (p.Met868Thr)	rs780280765	0.00001
NM_000179.3(MSH6):c.3565A>G (p.Thr1189Ala)	rs753778809	0.00001
NM_000179.3(MSH6):c.4039G>C (p.Ala1347Pro)	rs730881809	0.00001
NM_000179.3(MSH6):c.503C>G (p.Ala168Gly)	rs774162322	0.00001
NM_000179.3(MSH6):c.898C>T (p.Arg300Trp)	rs779858670	0.00001
NM_000179.3(MSH6):c.980C>G (p.Thr327Ser)	rs369568820	0.00001
NM_000179.3(MSH6):c.1955G>C (p.Gly652Ala)	rs1558663683
NM_000179.3(MSH6):c.1971G>C (p.Gln657His)	rs1553413339
NM_000179.3(MSH6):c.2078A>C (p.Lys693Thr)
NM_000179.3(MSH6):c.2398G>A (p.Val800Ile)	rs61748083
NM_000179.3(MSH6):c.3090G>T (p.Lys1030Asn)
NM_000179.3(MSH6):c.3101G>A (p.Arg1034Gln)	rs181727939
NM_000179.3(MSH6):c.3259C>G (p.Pro1087Ala)	rs63750998
NM_000179.3(MSH6):c.3260C>G (p.Pro1087Arg)	rs63750753
NM_000179.3(MSH6):c.3348C>G (p.Gly1116=)	rs771833309
NM_000179.3(MSH6):c.3383A>C (p.Tyr1128Ser)
NM_000179.3(MSH6):c.3438+8dup	rs878853734
NM_000179.3(MSH6):c.3680T>C (p.Ile1227Thr)
NM_000179.3(MSH6):c.41C>T (p.Ser14Phe)	rs863224628
NM_000179.3(MSH6):c.782C>G (p.Ser261Cys)	rs876661250
NM_000179.3(MSH6):c.866_867delinsAA (p.Gly289Glu)	rs267608079
NM_000179.3(MSH6):c.922G>A (p.Gly308Ser)	rs370174372
NM_000179.3(MSH6):c.95G>T (p.Gly32Val)	rs771426932

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