List of variants in gene MSH2 reported as benign for Hereditary cancer-predisposing syndrome

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 101

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HGVS	dbSNP	gnomAD frequency
NM_000251.3(MSH2):c.211+9C>G	rs2303426	0.55454
NM_000251.3(MSH2):c.1661+12G>A	rs3732183	0.40290
NM_000251.2(MSH2):c.-118T>C	rs2303425	0.10354
NM_000251.3(MSH2):c.1511-9A>T	rs12998837	0.09123
NM_000251.3(MSH2):c.2006-6T>C	rs2303428	0.08349
NM_000251.3(MSH2):c.1760-62G>A	rs17218439	0.02701
NM_000251.3(MSH2):c.380A>G (p.Asn127Ser)	rs17217772	0.02317
NM_000251.3(MSH2):c.573C>T (p.Leu191=)	rs1800151	0.01972
NM_000251.3(MSH2):c.965G>A (p.Gly322Asp)	rs4987188	0.01714
NM_000251.3(MSH2):c.1077-10T>C	rs17224360	0.01428
NM_000251.3(MSH2):c.2766T>C (p.Phe922=)	rs55859129	0.01118
NM_000251.3(MSH2):c.984C>T (p.Ala328=)	rs4987189	0.00495
NM_000251.3(MSH2):c.1077-229C>T	rs148883469	0.00492
NM_000251.3(MSH2):c.1666T>C (p.Leu556=)	rs61756466	0.00471
NM_000251.3(MSH2):c.1662-9G>A	rs17218356	0.00398
NM_000251.3(MSH2):c.339G>A (p.Lys113=)	rs35898375	0.00313
NM_000251.3(MSH2):c.23C>T (p.Thr8Met)	rs17217716	0.00184
NM_000251.1(MSH2):c.-179C>T	rs17224094	0.00159
NM_000251.3(MSH2):c.1277-8T>C	rs145400590	0.00159
NM_000251.3(MSH2):c.1387-8G>T	rs187525243	0.00143
NM_000251.3(MSH2):c.1737A>G (p.Lys579=)	rs61756467	0.00138
NM_000251.3(MSH2):c.819A>G (p.Val273=)	rs146577635	0.00101
NM_000251.3(MSH2):c.1563T>C (p.Tyr521=)	rs63750330	0.00053
NM_000251.3(MSH2):c.815C>T (p.Ala272Val)	rs34136999	0.00046
NM_000251.3(MSH2):c.1680T>C (p.Asn560=)	rs200056411	0.00043
NM_000251.3(MSH2):c.*129T>C	rs587779059	0.00042
NM_000251.3(MSH2):c.1886A>G (p.Gln629Arg)	rs61756468	0.00042
NM_000251.3(MSH2):c.1168C>T (p.Leu390Phe)	rs17224367	0.00039
NM_000251.3(MSH2):c.2154A>G (p.Gln718=)	rs63750810	0.00033
NM_000251.3(MSH2):c.471C>A (p.Gly157=)	rs61756463	0.00029
NM_000251.3(MSH2):c.1787A>G (p.Asn596Ser)	rs41295288	0.00022
NM_000251.3(MSH2):c.1255C>A (p.Gln419Lys)	rs63750006	0.00019
NM_000251.3(MSH2):c.505A>G (p.Ile169Val)	rs63750716	0.00013
NM_000251.3(MSH2):c.2203A>G (p.Ile735Val)	rs2229061	0.00011
NM_000251.3(MSH2):c.2308A>G (p.Ile770Val)	rs63750684	0.00011
NM_000251.3(MSH2):c.317G>A (p.Arg106Lys)	rs41295286	0.00009
NM_000251.3(MSH2):c.97A>C (p.Thr33Pro)	rs63751107	0.00009
NM_000251.3(MSH2):c.1159C>T (p.Leu387Phe)	rs751249745	0.00008
NM_000251.3(MSH2):c.2500G>A (p.Ala834Thr)	rs63750757	0.00008
NM_000251.3(MSH2):c.1560A>G (p.Gly520=)	rs63750820	0.00007
NM_000251.3(MSH2):c.818T>C (p.Val273Ala)	rs144288433	0.00007
NM_000251.3(MSH2):c.499G>C (p.Asp167His)	rs63750255	0.00006
NM_000251.3(MSH2):c.512G>A (p.Arg171Lys)	rs63750902	0.00006
NM_000251.3(MSH2):c.944G>T (p.Gly315Val)	rs202026056	0.00006
NM_000251.3(MSH2):c.1121A>G (p.Gln374Arg)	rs749660228	0.00004
NM_000251.3(MSH2):c.1189C>G (p.Gln397Glu)	rs63750611	0.00004
NM_000251.3(MSH2):c.2516A>G (p.His839Arg)	rs63750027	0.00004
NM_000251.3(MSH2):c.1847C>G (p.Pro616Arg)	rs587779965	0.00003
NM_000251.3(MSH2):c.1963G>A (p.Val655Ile)	rs549467183	0.00003
NM_000251.3(MSH2):c.2205C>T (p.Ile735=)	rs533553381	0.00003
NM_000251.3(MSH2):c.817G>A (p.Val273Ile)	rs530814648	0.00003
NM_000251.3(MSH2):c.1717G>A (p.Ala573Thr)	rs200766962	0.00002
NM_000251.3(MSH2):c.232G>A (p.Val78Ile)	rs772779997	0.00002
NM_000251.3(MSH2):c.123C>G (p.Asp41Glu)	rs761960690	0.00001
NM_000251.3(MSH2):c.1378A>G (p.Met460Val)	rs575905950	0.00001
NM_000251.3(MSH2):c.1480T>C (p.Ser494Pro)	rs55653533	0.00001
NM_000251.3(MSH2):c.1781C>T (p.Thr594Ile)	rs1553368510	0.00001
NM_000251.3(MSH2):c.1897A>G (p.Ile633Val)	rs771695599	0.00001
NM_000251.3(MSH2):c.2064G>A (p.Met688Ile)	rs63750790	0.00001
NM_000251.3(MSH2):c.2197G>A (p.Ala733Thr)	rs772662439	0.00001
NM_000251.3(MSH2):c.266T>C (p.Val89Ala)	rs876659747	0.00001
NM_000251.3(MSH2):c.274C>G (p.Leu92Val)	rs587779154	0.00001
NM_000251.3(MSH2):c.362A>G (p.Tyr121Cys)	rs587779971	0.00001
NM_000251.3(MSH2):c.716A>G (p.Gln239Arg)	rs199676483	0.00001
NM_000251.3(MSH2):c.962C>G (p.Thr321Ser)	rs1233448699	0.00001
NM_000251.3(MSH2):c.972G>A (p.Gln324=)	rs63750505	0.00001
NM_000251.3(MSH2):c.1076+171del	rs17217884
NM_000251.3(MSH2):c.1322C>T (p.Thr441Ile)	rs1553361210
NM_000251.3(MSH2):c.1387-14_1387-11del	rs370436680
NM_000251.3(MSH2):c.1518C>A (p.Asp506Glu)	rs1553366508
NM_000251.3(MSH2):c.1661+17T>G	rs377461923
NM_000251.3(MSH2):c.1662-18T>C	rs376235435
NM_000251.3(MSH2):c.1837A>C (p.Asn613His)	rs200147804
NM_000251.3(MSH2):c.1868C>T (p.Ala623Val)	rs781698416
NM_000251.3(MSH2):c.1906G>A (p.Ala636Thr)
NM_000251.3(MSH2):c.190A>G (p.Ile64Val)	rs1166747167
NM_000251.3(MSH2):c.1942A>G (p.Ile648Val)
NM_000251.3(MSH2):c.2005+8dup	rs267607992
NM_000251.3(MSH2):c.212-4dup	rs746333570
NM_000251.3(MSH2):c.2210+11_2210+22del	rs730881782
NM_000251.3(MSH2):c.2503A>G (p.Asn835Asp)	rs41295296
NM_000251.3(MSH2):c.2572G>A (p.Gly858Arg)	rs754533481
NM_000251.3(MSH2):c.2575G>A (p.Glu859Lys)	rs63749830
NM_000251.3(MSH2):c.2726A>T (p.Lys909Ile)	rs34319539
NM_000251.3(MSH2):c.273TCT[2] (p.Leu94del)	rs267607919
NM_000251.3(MSH2):c.391T>G (p.Phe131Val)	rs755423698
NM_000251.3(MSH2):c.403C>G (p.Leu135Val)	rs193096019
NM_000251.3(MSH2):c.421A>G (p.Met141Val)	rs193922374
NM_000251.3(MSH2):c.67T>C (p.Phe23Leu)	rs372619120
NM_000251.3(MSH2):c.793-23G>A	rs17224255
NM_000251.3(MSH2):c.942+16_942+29del	rs11309117
NM_000251.3(MSH2):c.942+17_942+29del	rs11309117
NM_000251.3(MSH2):c.942+19_942+29del	rs11309117
NM_000251.3(MSH2):c.942+20_942+29del	rs11309117
NM_000251.3(MSH2):c.942+21_942+29del	rs11309117
NM_000251.3(MSH2):c.942+22_942+29del	rs11309117
NM_000251.3(MSH2):c.942+25_942+29del	rs11309117
NM_000251.3(MSH2):c.942+26_942+29del	rs11309117
NM_000251.3(MSH2):c.942+27_942+29del	rs11309117
NM_000251.3(MSH2):c.942+28_942+29del	rs11309117
NM_000251.3(MSH2):c.942+29del	rs11309117

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