ClinVar Miner

List of variants studied for Hereditary spastic paraplegia 48 by Illumina Laboratory Services, Illumina

Minimum submission review status: Collection method:
Minimum conflict level:
ClinVar version:
Total variants: 280
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_014855.3(AP5Z1):c.*2623A>C rs2880933 0.31879
NM_014855.3(AP5Z1):c.759C>T (p.Ser253=) rs17135121 0.22358
NM_014855.3(AP5Z1):c.1707+11T>C rs3750012 0.17011
NM_014855.3(AP5Z1):c.*953T>C rs11976063 0.11462
NM_014855.3(AP5Z1):c.*1687T>C rs76039626 0.09958
NM_014855.3(AP5Z1):c.*1505C>T rs73305396 0.09937
NM_014855.3(AP5Z1):c.512-7A>G rs73305371 0.07873
NM_014855.3(AP5Z1):c.*45A>G rs12154545 0.06846
NM_014855.3(AP5Z1):c.*378T>C rs12154696 0.06569
NM_014855.3(AP5Z1):c.*276T>C rs12154622 0.06486
NM_014855.3(AP5Z1):c.*761G>A rs115198050 0.06399
NM_014855.3(AP5Z1):c.*1355G>A rs6967542 0.06387
NM_014855.3(AP5Z1):c.970-13C>T rs73305376 0.06374
NM_014855.3(AP5Z1):c.1377C>T (p.Asp459=) rs17135128 0.06038
NM_014855.3(AP5Z1):c.*205G>A rs73305394 0.05882
NM_014855.3(AP5Z1):c.*2093A>G rs7784925 0.05677
NM_014855.3(AP5Z1):c.1124T>A (p.Leu375Gln) rs11772411 0.05021
NM_014855.3(AP5Z1):c.1131C>T (p.His377=) rs11768079 0.04978
NM_014855.3(AP5Z1):c.*250T>G rs12154621 0.04580
NM_014855.3(AP5Z1):c.1939-9C>T rs73305392 0.04460
NM_014855.3(AP5Z1):c.*665T>C rs78468795 0.04423
NM_014855.3(AP5Z1):c.*1555C>G rs78049494 0.04406
NM_014855.3(AP5Z1):c.*1182C>T rs11971803 0.04393
NM_014855.3(AP5Z1):c.*2286G>A rs111762282 0.04368
NM_014855.3(AP5Z1):c.*922C>T rs11971749 0.04290
NM_014855.3(AP5Z1):c.*659G>A rs140612456 0.03865
NM_014855.3(AP5Z1):c.*2882A>G rs113428873 0.03836
NM_014855.3(AP5Z1):c.*2841A>G rs62453211 0.03480
NM_014855.3(AP5Z1):c.*1441C>T rs112405589 0.02801
NM_014855.3(AP5Z1):c.*2599T>C rs143539039 0.02522
NM_014855.3(AP5Z1):c.1554C>T (p.Phe518=) rs77560694 0.02284
NM_014855.3(AP5Z1):c.1708-14C>T rs118139547 0.02183
NM_014855.3(AP5Z1):c.*2849G>T rs149076549 0.02042
NM_014855.3(AP5Z1):c.*2501G>A rs115452328 0.01978
NM_014855.3(AP5Z1):c.*68G>A rs73305393 0.01965
NM_014855.3(AP5Z1):c.2098G>A (p.Val700Met) rs11766611 0.01795
NM_014855.3(AP5Z1):c.*2197A>G rs187056670 0.01683
NM_014855.3(AP5Z1):c.*2244G>A rs117144087 0.01674
NM_014855.3(AP5Z1):c.1529G>A (p.Arg510Gln) rs77890266 0.01561
NM_014855.3(AP5Z1):c.333G>C (p.Gln111His) rs11549840 0.01556
NM_014855.3(AP5Z1):c.*1594C>A rs138654444 0.01555
NM_014855.3(AP5Z1):c.1197G>A (p.Glu399=) rs117666541 0.01551
NM_014855.3(AP5Z1):c.*856G>A rs148032002 0.01546
NM_014855.3(AP5Z1):c.1369C>T (p.Leu457=) rs111358719 0.01503
NM_014855.3(AP5Z1):c.*901C>T rs112176131 0.01465
NM_014855.3(AP5Z1):c.2379G>T (p.Thr793=) rs77393809 0.01379
NM_014855.3(AP5Z1):c.281C>G (p.Ser94Cys) rs11549839 0.01367
NM_014855.3(AP5Z1):c.*586T>C rs34767537 0.01362
NM_014855.3(AP5Z1):c.379G>A (p.Glu127Lys) rs115454162 0.01129
NM_014855.3(AP5Z1):c.1708-5C>T rs184752711 0.00977
NM_014855.3(AP5Z1):c.*2490G>C rs150684624 0.00831
NM_014855.3(AP5Z1):c.*2198G>C rs148554790 0.00813
NM_014855.3(AP5Z1):c.1132+14G>T rs139019097 0.00792
NM_014855.3(AP5Z1):c.*1670G>C rs149234202 0.00696
NM_014855.3(AP5Z1):c.*92G>A rs112283999 0.00696
NM_014855.3(AP5Z1):c.-3G>A rs142983676 0.00667
NM_014855.3(AP5Z1):c.*2678T>C rs186689012 0.00647
NM_014855.3(AP5Z1):c.2230G>A (p.Ala744Thr) rs183580097 0.00602
NM_014855.3(AP5Z1):c.-1G>C rs146143723 0.00560
NM_014855.3(AP5Z1):c.*1641A>C rs192055966 0.00486
NM_014855.3(AP5Z1):c.*1187G>A rs188242891 0.00485
NM_014855.3(AP5Z1):c.*150G>A rs186823399 0.00478
NM_014855.3(AP5Z1):c.*2334C>T rs533072379 0.00435
NM_014855.3(AP5Z1):c.*1760G>A rs77146005 0.00418
NM_014855.3(AP5Z1):c.*2710A>G rs193143390 0.00410
NM_014855.3(AP5Z1):c.*532G>A rs527985598 0.00387
NM_014855.3(AP5Z1):c.*897G>A rs572278037 0.00383
NM_014855.3(AP5Z1):c.*2013C>T rs191668940 0.00378
NM_014855.3(AP5Z1):c.*2858G>C rs193054132 0.00371
NM_014855.3(AP5Z1):c.*734G>C rs193235922 0.00363
NM_014855.3(AP5Z1):c.1557A>G (p.Gln519=) rs201687417 0.00341
NM_014855.3(AP5Z1):c.*1065C>T rs558005571 0.00332
NM_014855.3(AP5Z1):c.126C>T (p.Leu42=) rs146682319 0.00321
NM_014855.3(AP5Z1):c.*531G>A rs114076345 0.00320
NM_014855.3(AP5Z1):c.900C>T (p.Tyr300=) rs146915189 0.00319
NM_014855.3(AP5Z1):c.*2222G>A rs377673816 0.00318
NM_014855.3(AP5Z1):c.*2719C>A rs140555165 0.00299
NM_014855.3(AP5Z1):c.*1733C>T rs182383318 0.00291
NM_014855.3(AP5Z1):c.881G>A (p.Arg294Gln) rs200957609 0.00278
NM_014855.3(AP5Z1):c.*2338G>A rs189898090 0.00267
NM_014855.3(AP5Z1):c.*2642T>G rs537332416 0.00262
NM_014855.3(AP5Z1):c.*537G>A rs146804830 0.00248
NM_014855.3(AP5Z1):c.*432C>G rs149131747 0.00245
NM_014855.3(AP5Z1):c.366+5C>T rs143800095 0.00227
NM_014855.3(AP5Z1):c.*910G>A rs773520179 0.00226
NM_014855.3(AP5Z1):c.481G>A (p.Val161Met) rs191971593 0.00201
NM_014855.3(AP5Z1):c.*690A>G rs145742120 0.00185
NM_014855.3(AP5Z1):c.1062C>T (p.His354=) rs192441133 0.00114
NM_014855.3(AP5Z1):c.1563G>A (p.Leu521=) rs182411153 0.00105
NM_014855.3(AP5Z1):c.558C>T (p.Tyr186=) rs371534878 0.00092
NM_014855.3(AP5Z1):c.*766C>T rs549943787 0.00091
NM_014855.3(AP5Z1):c.*561C>T rs538631490 0.00084
NM_014855.3(AP5Z1):c.999C>T (p.Asp333=) rs201196622 0.00079
NM_014855.3(AP5Z1):c.*1576T>G rs539916245 0.00073
NM_014855.3(AP5Z1):c.*648C>T rs577133170 0.00073
NM_014855.3(AP5Z1):c.1773C>T (p.Tyr591=) rs372922535 0.00073
NM_014855.3(AP5Z1):c.2131C>G (p.Arg711Gly) rs113184057 0.00073
NM_014855.3(AP5Z1):c.1528C>T (p.Arg510Trp) rs374146548 0.00072
NM_014855.3(AP5Z1):c.*2812C>T rs144268420 0.00071
NM_014855.3(AP5Z1):c.1936G>A (p.Val646Met) rs200280538 0.00065
NM_014855.3(AP5Z1):c.1964C>T (p.Ser655Leu) rs61750324 0.00065
NM_014855.3(AP5Z1):c.*2624A>G rs1055465900 0.00063
NM_014855.3(AP5Z1):c.1584C>T (p.Gly528=) rs377310579 0.00060
NM_014855.3(AP5Z1):c.849C>T (p.Ala283=) rs572271008 0.00060
NM_014855.3(AP5Z1):c.*2068C>A rs561538511 0.00058
NM_014855.3(AP5Z1):c.588C>T (p.Ser196=) rs146665638 0.00053
NM_014855.3(AP5Z1):c.970-5C>T rs373671779 0.00052
NM_014855.3(AP5Z1):c.*683G>A rs763158624 0.00046
NM_014855.3(AP5Z1):c.780C>A (p.Thr260=) rs377507553 0.00046
NM_014855.3(AP5Z1):c.584A>G (p.His195Arg) rs117659667 0.00044
NM_014855.3(AP5Z1):c.*2983C>T rs181118091 0.00039
NM_014855.3(AP5Z1):c.1595+4C>T rs141607676 0.00039
NM_014855.3(AP5Z1):c.1806-15C>T rs201620155 0.00038
NM_014855.3(AP5Z1):c.313C>T (p.His105Tyr) rs200490093 0.00038
NM_014855.3(AP5Z1):c.*373G>A rs575299983 0.00033
NM_014855.3(AP5Z1):c.*1736C>G rs781023359 0.00032
NM_014855.3(AP5Z1):c.*1866C>A rs748344258 0.00031
NM_014855.3(AP5Z1):c.*2167G>A rs182688215 0.00031
NM_014855.3(AP5Z1):c.2400G>A (p.Arg800=) rs368571200 0.00030
NM_014855.3(AP5Z1):c.671C>T (p.Thr224Met) rs201862383 0.00029
NM_014855.3(AP5Z1):c.*843G>A rs537779263 0.00028
NM_014855.3(AP5Z1):c.*2228C>T rs115179819 0.00027
NM_014855.3(AP5Z1):c.490A>G (p.Ser164Gly) rs202169962 0.00027
NM_014855.3(AP5Z1):c.*1738C>T rs768610280 0.00025
NM_014855.3(AP5Z1):c.*278G>A rs975774214 0.00023
NM_014855.3(AP5Z1):c.1785G>T (p.Gly595=) rs774921196 0.00023
NM_014855.3(AP5Z1):c.2387G>A (p.Arg796Gln) rs199981070 0.00022
NM_014855.3(AP5Z1):c.*1586C>T rs555597896 0.00021
NM_014855.3(AP5Z1):c.1724T>G (p.Leu575Arg) rs562425834 0.00019
NM_014855.3(AP5Z1):c.*629C>T rs558891748 0.00018
NM_014855.3(AP5Z1):c.*1881A>T rs886062363 0.00017
NM_014855.3(AP5Z1):c.1473C>G (p.Ser491=) rs370135619 0.00016
NM_014855.3(AP5Z1):c.1965G>A (p.Ser655=) rs543467648 0.00016
NM_014855.3(AP5Z1):c.691C>T (p.Arg231Cys) rs774832344 0.00016
NM_014855.3(AP5Z1):c.1953C>T (p.Gly651=) rs200617745 0.00015
NM_014855.3(AP5Z1):c.684C>T (p.Ser228=) rs746349613 0.00014
NM_014855.3(AP5Z1):c.*2109G>A rs766301854 0.00013
NM_014855.3(AP5Z1):c.*2496G>A rs753348874 0.00013
NM_014855.3(AP5Z1):c.2287G>A (p.Val763Met) rs147369435 0.00013
NM_014855.3(AP5Z1):c.*1562C>T rs150159238 0.00011
NM_014855.3(AP5Z1):c.*241G>A rs570957705 0.00011
NM_014855.3(AP5Z1):c.2386C>T (p.Arg796Trp) rs764310871 0.00011
NM_014855.3(AP5Z1):c.*896C>T rs886062356 0.00010
NM_014855.3(AP5Z1):c.1132+7C>T rs775865217 0.00010
NM_014855.3(AP5Z1):c.*2328G>A rs565562831 0.00009
NM_014855.3(AP5Z1):c.1341C>T (p.Thr447=) rs60284677 0.00009
NM_014855.3(AP5Z1):c.259G>A (p.Ala87Thr) rs775883752 0.00009
NM_014855.3(AP5Z1):c.59A>T (p.Glu20Val) rs781743376 0.00009
NM_014855.3(AP5Z1):c.*1003C>A rs565631932 0.00008
NM_014855.3(AP5Z1):c.1938+11C>T rs201888478 0.00008
NM_014855.3(AP5Z1):c.1617G>C (p.Leu539=) rs569601905 0.00007
NM_014855.3(AP5Z1):c.*1386C>T rs541829370 0.00006
NM_014855.3(AP5Z1):c.*2503G>A rs886062365 0.00006
NM_014855.3(AP5Z1):c.*668G>A rs375098115 0.00006
NM_014855.3(AP5Z1):c.-68G>T rs546354621 0.00006
NM_014855.3(AP5Z1):c.1334C>T (p.Pro445Leu) rs566333309 0.00006
NM_014855.3(AP5Z1):c.1919C>T (p.Ala640Val) rs562874262 0.00006
NM_014855.3(AP5Z1):c.351C>T (p.Ser117=) rs374912181 0.00006
NM_014855.3(AP5Z1):c.417G>A (p.Ala139=) rs201203264 0.00006
NM_014855.3(AP5Z1):c.605C>T (p.Thr202Met) rs756182519 0.00006
NM_014855.3(AP5Z1):c.628C>T (p.Pro210Ser) rs773542837 0.00006
NM_014855.3(AP5Z1):c.841T>A (p.Ser281Thr) rs765690642 0.00006
NM_014855.3(AP5Z1):c.*2153G>A rs111994210 0.00005
NM_014855.3(AP5Z1):c.*7A>G rs774520916 0.00005
NM_014855.3(AP5Z1):c.1356G>A (p.Ala452=) rs558636596 0.00005
NM_014855.3(AP5Z1):c.1422C>G (p.Pro474=) rs763844598 0.00005
NM_014855.3(AP5Z1):c.1974C>T (p.Tyr658=) rs375030531 0.00005
NM_014855.3(AP5Z1):c.535C>T (p.Arg179Trp) rs1040399898 0.00005
NM_014855.3(AP5Z1):c.*189G>A rs548571464 0.00004
NM_014855.3(AP5Z1):c.*2784C>T rs573731436 0.00004
NM_014855.3(AP5Z1):c.1464G>A (p.Pro488=) rs376913055 0.00004
NM_014855.3(AP5Z1):c.540G>A (p.Leu180=) rs768017182 0.00004
NM_014855.3(AP5Z1):c.660A>G (p.Thr220=) rs756140557 0.00004
NM_014855.3(AP5Z1):c.*2185C>T rs886062364 0.00003
NM_014855.3(AP5Z1):c.*2243C>T rs539348967 0.00003
NM_014855.3(AP5Z1):c.*820C>G rs575429444 0.00003
NM_014855.3(AP5Z1):c.1455-12C>T rs1038026978 0.00003
NM_014855.3(AP5Z1):c.497G>A (p.Gly166Asp) rs374914983 0.00003
NM_014855.3(AP5Z1):c.790+6C>T rs776469236 0.00003
NM_014855.3(AP5Z1):c.*119C>A rs576259662 0.00002
NM_014855.3(AP5Z1):c.1140G>A (p.Ala380=) rs766090660 0.00002
NM_014855.3(AP5Z1):c.589G>A (p.Gly197Ser) rs746939195 0.00002
NM_014855.3(AP5Z1):c.592G>A (p.Gly198Ser) rs757322471 0.00002
NM_014855.3(AP5Z1):c.702C>T (p.Asp234=) rs370728528 0.00002
NM_014855.3(AP5Z1):c.*1203G>A rs886062358 0.00001
NM_014855.3(AP5Z1):c.*1204C>G rs886062359 0.00001
NM_014855.3(AP5Z1):c.*1220A>G rs1446711478 0.00001
NM_014855.3(AP5Z1):c.*152G>T rs886062355 0.00001
NM_014855.3(AP5Z1):c.*1930T>C rs1284812693 0.00001
NM_014855.3(AP5Z1):c.*229G>A rs535419745 0.00001
NM_014855.3(AP5Z1):c.*261G>A rs1315573812 0.00001
NM_014855.3(AP5Z1):c.*2940C>T rs573728891 0.00001
NM_014855.3(AP5Z1):c.*346A>G rs1045763673 0.00001
NM_014855.3(AP5Z1):c.*625G>A rs959075651 0.00001
NM_014855.3(AP5Z1):c.*754G>A rs759877524 0.00001
NM_014855.3(AP5Z1):c.1072C>T (p.Arg358Cys) rs551568063 0.00001
NM_014855.3(AP5Z1):c.1119C>T (p.Phe373=) rs886062353 0.00001
NM_014855.3(AP5Z1):c.1132+10G>A rs763573216 0.00001
NM_014855.3(AP5Z1):c.1597T>C (p.Leu533=) rs775572689 0.00001
NM_014855.3(AP5Z1):c.1707+14C>T rs759055397 0.00001
NM_014855.3(AP5Z1):c.1863G>A (p.Glu621=) rs780422345 0.00001
NM_014855.3(AP5Z1):c.1963T>C (p.Ser655Pro) rs764228580 0.00001
NM_014855.3(AP5Z1):c.2089G>T (p.Val697Leu) rs769732363 0.00001
NM_014855.3(AP5Z1):c.2231C>T (p.Ala744Val) rs776245278 0.00001
NM_014855.3(AP5Z1):c.392C>T (p.Ala131Val) rs372539355 0.00001
NM_014855.3(AP5Z1):c.394G>A (p.Val132Met) rs886062349 0.00001
NM_014855.3(AP5Z1):c.412C>T (p.Arg138Ter) rs778457903 0.00001
NM_014855.3(AP5Z1):c.606G>A (p.Thr202=) rs928947081 0.00001
NM_014855.3(AP5Z1):c.631G>A (p.Val211Ile) rs771385792 0.00001
NM_014855.3(AP5Z1):c.790+7G>A rs759449685 0.00001
NM_014855.3(AP5Z1):c.*1039G>C rs115180718
NM_014855.3(AP5Z1):c.*1039G>T rs115180718
NM_014855.3(AP5Z1):c.*1094G>A rs140844502
NM_014855.3(AP5Z1):c.*1162C>G rs749324858
NM_014855.3(AP5Z1):c.*1219C>T rs572193795
NM_014855.3(AP5Z1):c.*1260G>A rs1183570786
NM_014855.3(AP5Z1):c.*1266C>T rs886062360
NM_014855.3(AP5Z1):c.*1357T>G rs1359983570
NM_014855.3(AP5Z1):c.*1458C>T rs896431597
NM_014855.3(AP5Z1):c.*1480T>G rs886062361
NM_014855.3(AP5Z1):c.*149C>G rs761922257
NM_014855.3(AP5Z1):c.*149C>T rs761922257
NM_014855.3(AP5Z1):c.*1587G>A rs1781833695
NM_014855.3(AP5Z1):c.*158C>A rs551093436
NM_014855.3(AP5Z1):c.*1679C>T rs1372377816
NM_014855.3(AP5Z1):c.*1701C>G rs80311758
NM_014855.3(AP5Z1):c.*1701C>T rs80311758
NM_014855.3(AP5Z1):c.*1750G>C rs886062362
NM_014855.3(AP5Z1):c.*1794C>T rs186935731
NM_014855.3(AP5Z1):c.*190A>C rs1232009202
NM_014855.3(AP5Z1):c.*19C>T rs1781768718
NM_014855.3(AP5Z1):c.*2004C>T rs143513418
NM_014855.3(AP5Z1):c.*206G>C rs1781776627
NM_014855.3(AP5Z1):c.*2241G>A rs1037534193
NM_014855.3(AP5Z1):c.*2306G>T rs540809527
NM_014855.3(AP5Z1):c.*2363C>T rs530936725
NM_014855.3(AP5Z1):c.*2364G>A rs1054789444
NM_014855.3(AP5Z1):c.*2411C>T rs571859846
NM_014855.3(AP5Z1):c.*2500C>T rs139997541
NM_014855.3(AP5Z1):c.*2574C>T rs886062366
NM_014855.3(AP5Z1):c.*2639G>C rs1205750842
NM_014855.3(AP5Z1):c.*2695T>C rs1309266493
NM_014855.3(AP5Z1):c.*2760G>A rs1781878084
NM_014855.3(AP5Z1):c.*2838A>G rs534373877
NM_014855.3(AP5Z1):c.*527G>A rs758084749
NM_014855.3(AP5Z1):c.*669G>T rs893447235
NM_014855.3(AP5Z1):c.*765C>G rs114829927
NM_014855.3(AP5Z1):c.*765C>T rs114829927
NM_014855.3(AP5Z1):c.*806G>C rs190210301
NM_014855.3(AP5Z1):c.*833C>G rs1329819591
NM_014855.3(AP5Z1):c.*880C>T rs535535946
NM_014855.3(AP5Z1):c.*940T>A rs1219881668
NM_014855.3(AP5Z1):c.*965C>G rs1337568762
NM_014855.3(AP5Z1):c.*971C>G rs529715248
NM_014855.3(AP5Z1):c.*999C>T rs1562417370
NM_014855.3(AP5Z1):c.-26C>T rs1049028734
NM_014855.3(AP5Z1):c.1015dup (p.Asp339fs) rs1562408333
NM_014855.3(AP5Z1):c.1315C>T (p.Leu439=) rs113014863
NM_014855.3(AP5Z1):c.1357C>G (p.Leu453Val) rs376979127
NM_014855.3(AP5Z1):c.1531G>T (p.Asp511Tyr) rs1781620399
NM_014855.3(AP5Z1):c.1573A>C (p.Lys525Gln) rs186003800
NM_014855.3(AP5Z1):c.1740G>A (p.Ala580=) rs773950276
NM_014855.3(AP5Z1):c.1794C>T (p.Ala598=) rs374673921
NM_014855.3(AP5Z1):c.1806-12C>T rs78959612
NM_014855.3(AP5Z1):c.1846C>A (p.Pro616Thr) rs1781727346
NM_014855.3(AP5Z1):c.2047C>A (p.Gln683Lys) rs886062354
NM_014855.3(AP5Z1):c.2102T>C (p.Leu701Pro) rs1317738698
NM_014855.3(AP5Z1):c.2151C>T (p.Pro717=) rs1781745482
NM_014855.3(AP5Z1):c.2153+8G>A rs189564026
NM_014855.3(AP5Z1):c.2174A>G (p.Lys725Arg) rs1781756221
NM_014855.3(AP5Z1):c.2248C>T (p.Arg750Trp) rs376075136
NM_014855.3(AP5Z1):c.2305A>G (p.Thr769Ala) rs188569082
NM_014855.3(AP5Z1):c.2328C>A (p.Ser776Arg) rs192794637
NM_014855.3(AP5Z1):c.2363C>G (p.Pro788Arg) rs893581542
NM_014855.3(AP5Z1):c.238G>A (p.Glu80Lys) rs199577559
NM_014855.3(AP5Z1):c.511+5G>A rs759729051
NM_014855.3(AP5Z1):c.585C>G (p.His195Gln) rs886062350
NM_014855.3(AP5Z1):c.724G>C (p.Ala242Pro) rs886062351
NM_014855.3(AP5Z1):c.790+15G>A rs886062352
NM_014855.3(AP5Z1):c.949G>T (p.Asp317Tyr) rs775289012

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.