ClinVar Miner

List of variants in gene TPM1 reported as likely benign for Hypertrophic cardiomyopathy

Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:
Total variants: 176
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HGVS dbSNP gnomAD frequency
NM_001018005.2(TPM1):c.486T>C (p.Tyr162=) rs11558747 0.05001
NM_001018004.2(TPM1):c.*119T>C rs138843544 0.02527
NM_001018005.1(TPM1):c.-206G>A rs17525848 0.00111
NM_001018005.2(TPM1):c.177A>G (p.Lys59=) rs149346709 0.00031
NM_001018005.2(TPM1):c.375-5T>C rs377061868 0.00029
NM_001018005.2(TPM1):c.851+6C>T rs375043184 0.00029
NM_001018005.2(TPM1):c.797A>G (p.Lys266Arg) rs371934474 0.00021
NM_001018005.2(TPM1):c.114+14C>T rs576659891 0.00014
NM_001018005.2(TPM1):c.726G>A (p.Ala242=) rs200484871 0.00011
NM_001018005.2(TPM1):c.522C>T (p.Ser174=) rs200173919 0.00010
NM_001018005.2(TPM1):c.563+12C>T rs756230680 0.00009
NM_001018005.2(TPM1):c.493-18T>G rs377726678 0.00006
NM_001018005.2(TPM1):c.563+7G>A rs374563216 0.00006
NM_001018005.2(TPM1):c.687C>T (p.Ser229=) rs759362606 0.00004
NM_001018005.2(TPM1):c.783C>T (p.Tyr261=) rs751001221 0.00004
NM_001018005.2(TPM1):c.851+7G>A rs765721221 0.00004
NM_001018005.2(TPM1):c.241-8C>T rs765893032 0.00003
NM_001018005.2(TPM1):c.474C>T (p.Ala158=) rs143922069 0.00003
NM_001018005.2(TPM1):c.549T>C (p.Ala183=) rs199476313 0.00003
NM_001018005.2(TPM1):c.563+16G>A rs375227208 0.00003
NM_001018005.2(TPM1):c.564-12C>T rs113591254 0.00003
NM_001018005.2(TPM1):c.845C>G (p.Thr282Ser) rs397516395 0.00003
NM_001018005.2(TPM1):c.240+11G>A rs367999295 0.00002
NM_001018005.2(TPM1):c.31C>T (p.Leu11=) rs766883758 0.00002
NM_001018005.2(TPM1):c.493-7G>A rs745830368 0.00002
NM_001018005.2(TPM1):c.564-5A>G rs550286836 0.00002
NM_001018005.2(TPM1):c.645G>A (p.Ser215=) rs773403386 0.00002
NM_001018005.2(TPM1):c.663T>C (p.Tyr221=) rs774859181 0.00002
NM_001018005.2(TPM1):c.773-5C>T rs754213660 0.00002
NM_001018005.2(TPM1):c.114+16G>C rs1304088652 0.00001
NM_001018005.2(TPM1):c.114+18C>A rs1442521579 0.00001
NM_001018005.2(TPM1):c.138G>A (p.Leu46=) rs200509525 0.00001
NM_001018005.2(TPM1):c.241-9T>C rs377417143 0.00001
NM_001018005.2(TPM1):c.252C>T (p.Asp84=) rs369617788 0.00001
NM_001018005.2(TPM1):c.273C>T (p.Arg91=) rs1400074860 0.00001
NM_001018005.2(TPM1):c.288G>A (p.Glu96=) rs192883939 0.00001
NM_001018005.2(TPM1):c.318G>T (p.Leu106=) rs1449770307 0.00001
NM_001018005.2(TPM1):c.375-18G>C rs1004179784 0.00001
NM_001018005.2(TPM1):c.39C>G (p.Leu13=) rs1439080260 0.00001
NM_001018005.2(TPM1):c.438C>T (p.Ile146=) rs1460142862 0.00001
NM_001018005.2(TPM1):c.444G>C (p.Leu148=) rs376518788 0.00001
NM_001018005.2(TPM1):c.493-6C>T rs397516374 0.00001
NM_001018005.2(TPM1):c.573C>T (p.Ala191=) rs780507307 0.00001
NM_001018005.2(TPM1):c.630G>A (p.Gln210=) rs761816813 0.00001
NM_001018005.2(TPM1):c.639+10G>A rs763272536 0.00001
NM_001018005.2(TPM1):c.684T>C (p.Leu228=) rs397516384 0.00001
NM_001018005.2(TPM1):c.6C>T (p.Asp2=) rs1350935943 0.00001
NM_001018005.2(TPM1):c.702+10G>C rs1386461337 0.00001
NM_001018005.2(TPM1):c.705T>C (p.Ala235=) rs1222579354 0.00001
NM_001018005.2(TPM1):c.768A>G (p.Leu256=) rs139650306 0.00001
NM_001018005.2(TPM1):c.773-18T>C rs759150466 0.00001
NM_001018005.2(TPM1):c.774C>T (p.Asp258=) rs762282433 0.00001
NM_001018005.2(TPM1):c.807C>T (p.Ala269=) rs751778912 0.00001
NM_001018005.2(TPM1):c.828C>T (p.His276=) rs368813394 0.00001
NM_001018005.2(TPM1):c.837C>T (p.Asn279=) rs397516393 0.00001
NM_001018005.2(TPM1):c.840T>C (p.Asp280=) rs749271066 0.00001
NM_001018005.2(TPM1):c.852-4G>A rs374970923 0.00001
NM_001018005.2(TPM1):c.852-5C>T rs766724527 0.00001
NM_001018005.2(TPM1):c.93G>C (p.Ala31=) rs770661916 0.00001
NM_001018005.2(TPM1):c.111G>A (p.Lys37=) rs2140596743
NM_001018005.2(TPM1):c.114+10T>C rs2140597303
NM_001018005.2(TPM1):c.114+12C>T
NM_001018005.2(TPM1):c.114+15G>C
NM_001018005.2(TPM1):c.114+15G>T rs552212991
NM_001018005.2(TPM1):c.114+19C>T
NM_001018005.2(TPM1):c.114+20T>G
NM_001018005.2(TPM1):c.115-19C>T
NM_001018005.2(TPM1):c.115-5C>T
NM_001018005.2(TPM1):c.123T>C (p.Asp41=) rs1029129685
NM_001018005.2(TPM1):c.126G>A (p.Glu42=) rs2031852609
NM_001018005.2(TPM1):c.132G>A (p.Val44=) rs2140627644
NM_001018005.2(TPM1):c.141A>G (p.Gln47=)
NM_001018005.2(TPM1):c.144G>A (p.Lys48=) rs1555403374
NM_001018005.2(TPM1):c.150C>A (p.Leu50=) rs2140627934
NM_001018005.2(TPM1):c.153G>A (p.Lys51=) rs1555403378
NM_001018005.2(TPM1):c.15G>A (p.Lys5=) rs2140594119
NM_001018005.2(TPM1):c.162A>G (p.Glu54=)
NM_001018005.2(TPM1):c.183T>C (p.Ser61=)
NM_001018005.2(TPM1):c.207G>A (p.Glu69=)
NM_001018005.2(TPM1):c.21G>A (p.Lys7=) rs2140594266
NM_001018005.2(TPM1):c.240+16C>T
NM_001018005.2(TPM1):c.240+9A>G
NM_001018005.2(TPM1):c.241-10C>T rs917063084
NM_001018005.2(TPM1):c.241-13A>C
NM_001018005.2(TPM1):c.241-19C>G
NM_001018005.2(TPM1):c.241-6A>G
NM_001018005.2(TPM1):c.294G>A (p.Glu98=) rs747206706
NM_001018005.2(TPM1):c.297G>A (p.Leu99=)
NM_001018005.2(TPM1):c.312G>A (p.Glu104=)
NM_001018005.2(TPM1):c.327T>G (p.Ala109=) rs2140908643
NM_001018005.2(TPM1):c.345A>G (p.Glu115=) rs1596361307
NM_001018005.2(TPM1):c.374+16C>T
NM_001018005.2(TPM1):c.374+19C>A
NM_001018005.2(TPM1):c.375-8C>A
NM_001018005.2(TPM1):c.375-8_375-5del rs2140936859
NM_001018005.2(TPM1):c.384A>G (p.Lys128=)
NM_001018005.2(TPM1):c.390T>C (p.Ile130=)
NM_001018005.2(TPM1):c.417A>G (p.Glu139=) rs2140937690
NM_001018005.2(TPM1):c.441A>G (p.Gln147=) rs1596372306
NM_001018005.2(TPM1):c.45G>A (p.Lys15=) rs199476301
NM_001018005.2(TPM1):c.492+11G>T
NM_001018005.2(TPM1):c.492+16C>A
NM_001018005.2(TPM1):c.492+17dup
NM_001018005.2(TPM1):c.492+19A>C
NM_001018005.2(TPM1):c.492+19A>G
NM_001018005.2(TPM1):c.492+9C>G rs2140938836
NM_001018005.2(TPM1):c.493-10C>T rs1051722554
NM_001018005.2(TPM1):c.493-13C>T rs143628676
NM_001018005.2(TPM1):c.493-17G>A rs1055806170
NM_001018005.2(TPM1):c.493-9del
NM_001018005.2(TPM1):c.51C>T (p.Asn17=) rs878854150
NM_001018005.2(TPM1):c.534T>C (p.Arg178=)
NM_001018005.2(TPM1):c.546G>A (p.Arg182=) rs1555409143
NM_001018005.2(TPM1):c.561A>G (p.Glu187=)
NM_001018005.2(TPM1):c.563+13G>A
NM_001018005.2(TPM1):c.563+15C>T
NM_001018005.2(TPM1):c.563+17C>T
NM_001018005.2(TPM1):c.563+9G>A
NM_001018005.2(TPM1):c.564-11dup
NM_001018005.2(TPM1):c.564-12C>G rs113591254
NM_001018005.2(TPM1):c.564-14A>G
NM_001018005.2(TPM1):c.564-15G>T
NM_001018005.2(TPM1):c.564-19C>G
NM_001018005.2(TPM1):c.564-8A>C rs2140963062
NM_001018005.2(TPM1):c.573C>G (p.Ala191=)
NM_001018005.2(TPM1):c.585A>G (p.Glu195=) rs3218717
NM_001018005.2(TPM1):c.588A>G (p.Glu196=)
NM_001018005.2(TPM1):c.589T>C (p.Leu197=) rs2140963629
NM_001018005.2(TPM1):c.603G>C (p.Thr201=) rs397516485
NM_001018005.2(TPM1):c.606C>T (p.Asn202=) rs1225777387
NM_001018005.2(TPM1):c.618A>T (p.Ser206=)
NM_001018005.2(TPM1):c.619C>T (p.Leu207=)
NM_001018005.2(TPM1):c.61C>A (p.Arg21=) rs1437698471
NM_001018005.2(TPM1):c.627T>G (p.Ala209=) rs769210513
NM_001018005.2(TPM1):c.639+13del rs397516488
NM_001018005.2(TPM1):c.639+14A>G rs2140964792
NM_001018005.2(TPM1):c.639+16G>A
NM_001018005.2(TPM1):c.639+20T>C
NM_001018005.2(TPM1):c.640-14C>T rs781638696
NM_001018005.2(TPM1):c.640-4A>G rs2140969178
NM_001018005.2(TPM1):c.640-4_640-3insAA
NM_001018005.2(TPM1):c.645G>T (p.Ser215=) rs773403386
NM_001018005.2(TPM1):c.678G>A (p.Lys226=)
NM_001018005.2(TPM1):c.681C>G (p.Val227=) rs2140969848
NM_001018005.2(TPM1):c.681C>T (p.Val227=)
NM_001018005.2(TPM1):c.687C>G (p.Ser229=)
NM_001018005.2(TPM1):c.702+12G>A
NM_001018005.2(TPM1):c.702+15G>C rs2140970549
NM_001018005.2(TPM1):c.702+16T>C
NM_001018005.2(TPM1):c.702+7T>A rs201873332
NM_001018005.2(TPM1):c.702+7del rs1060504368
NM_001018005.2(TPM1):c.703-14A>G
NM_001018005.2(TPM1):c.703-16A>G
NM_001018005.2(TPM1):c.703-8C>T
NM_001018005.2(TPM1):c.759T>C (p.Ile253=)
NM_001018005.2(TPM1):c.75G>T (p.Ala25=) rs1214191576
NM_001018005.2(TPM1):c.772+12A>G
NM_001018005.2(TPM1):c.772+14T>C
NM_001018005.2(TPM1):c.772+15A>G
NM_001018005.2(TPM1):c.772+16G>A
NM_001018005.2(TPM1):c.772+8C>T
NM_001018005.2(TPM1):c.773-4A>G rs1555410410
NM_001018005.2(TPM1):c.773-6T>A rs374049254
NM_001018005.2(TPM1):c.773-8G>C rs1480009148
NM_001018005.2(TPM1):c.786T>C (p.Ala262=) rs2140991865
NM_001018005.2(TPM1):c.813C>T (p.Ser271=)
NM_001018005.2(TPM1):c.822G>A (p.Leu274=) rs2140992413
NM_001018005.2(TPM1):c.831T>C (p.Ala277=)
NM_001018005.2(TPM1):c.851+14C>T rs2140993340
NM_001018005.2(TPM1):c.851+7G>T
NM_001018005.2(TPM1):c.851+7del
NM_001018005.2(TPM1):c.852-10C>T rs1407421108
NM_001018005.2(TPM1):c.852-12A>G rs1414878944
NM_001018005.2(TPM1):c.852-6A>G
NM_001018005.2(TPM1):c.87G>A (p.Lys29=) rs530234301
NM_001018005.2(TPM1):c.99A>G (p.Glu33=)

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