ClinVar Miner

List of variants in gene MLH1 reported as likely benign for Lynch syndrome

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Gene type:
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Total variants: 162
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HGVS dbSNP gnomAD frequency
NM_000249.4(MLH1):c.2152C>T (p.His718Tyr) rs2020873 0.02345
NM_000249.4(MLH1):c.588+11G>C rs4647258 0.00993
NM_000249.4(MLH1):c.589-15C>T rs55658850 0.00582
NM_000249.4(MLH1):c.1852A>G (p.Lys618Glu) rs35001569 0.00399
NM_000249.4(MLH1):c.1963A>G (p.Ile655Val) rs55907433 0.00297
NM_000249.4(MLH1):c.885-24T>A rs201594027 0.00164
NM_000249.4(MLH1):c.1217G>A (p.Ser406Asn) rs41294980 0.00087
NM_000249.4(MLH1):c.375A>G (p.Ala125=) rs1800144 0.00062
NM_000249.4(MLH1):c.1410-10T>G rs372053184 0.00044
NM_000249.4(MLH1):c.702G>A (p.Glu234=) rs35908749 0.00041
NM_000249.4(MLH1):c.198C>T (p.Thr66=) rs61751642 0.00040
NM_000249.4(MLH1):c.487A>C (p.Arg163=) rs748500860 0.00029
NM_000249.4(MLH1):c.307-19A>G rs121909451 0.00022
NM_000249.4(MLH1):c.2101C>A (p.Gln701Lys) rs63750114 0.00016
NM_000249.4(MLH1):c.1820T>A (p.Leu607His) rs41295284 0.00015
NM_000249.4(MLH1):c.2001C>T (p.Asp667=) rs63750014 0.00014
NM_000249.4(MLH1):c.843A>C (p.Ala281=) rs146796765 0.00012
NM_000249.4(MLH1):c.626A>G (p.Asn209Ser) rs150478207 0.00011
NM_000249.4(MLH1):c.1808C>G (p.Pro603Arg) rs63750876 0.00009
NM_000249.4(MLH1):c.1742C>T (p.Pro581Leu) rs63751684 0.00008
NM_000249.4(MLH1):c.117-10G>A rs576724240 0.00007
NM_000249.4(MLH1):c.1908G>A (p.Leu636=) rs1800145 0.00007
NM_000249.4(MLH1):c.42A>C (p.Thr14=) rs369737664 0.00007
NM_000249.4(MLH1):c.1104G>A (p.Ser368=) rs769364808 0.00006
NM_000249.4(MLH1):c.545+43C>G rs267607761 0.00006
NM_000249.4(MLH1):c.552A>T (p.Ser184=) rs35225190 0.00006
NM_000249.4(MLH1):c.69A>G (p.Glu23=) rs63750555 0.00006
NM_000249.4(MLH1):c.1128T>C (p.Asp376=) rs267607824 0.00005
NM_000249.4(MLH1):c.1392T>C (p.Pro464=) rs63750201 0.00005
NM_000249.4(MLH1):c.438A>G (p.Gln146=) rs377279035 0.00005
NM_000249.4(MLH1):c.1270G>A (p.Ala424Thr) rs377433038 0.00004
NM_000249.4(MLH1):c.1284T>C (p.Asp428=) rs772555970 0.00004
NM_000249.4(MLH1):c.1474G>A (p.Ala492Thr) rs63751145 0.00004
NM_000249.4(MLH1):c.1779A>G (p.Pro593=) rs786201766 0.00004
NM_000249.4(MLH1):c.2252A>G (p.Lys751Arg) rs140195825 0.00004
NM_000249.4(MLH1):c.579A>G (p.Ser193=) rs587781038 0.00004
NM_000249.4(MLH1):c.808A>G (p.Thr270Ala) rs371302926 0.00004
NM_000249.4(MLH1):c.9C>G (p.Phe3Leu) rs779759678 0.00004
NM_000249.4(MLH1):c.1743G>A (p.Pro581=) rs567838745 0.00003
NM_000249.4(MLH1):c.1976G>A (p.Arg659Gln) rs63749900 0.00003
NM_000249.4(MLH1):c.462C>T (p.Asp154=) rs192938577 0.00003
NM_000249.4(MLH1):c.927C>A (p.Pro309=) rs63749896 0.00003
NM_000249.4(MLH1):c.94A>G (p.Ile32Val) rs2020872 0.00003
NM_000249.4(MLH1):c.1515T>C (p.Ser505=) rs774699212 0.00002
NM_000249.4(MLH1):c.1872C>T (p.Asp624=) rs145535636 0.00002
NM_000249.4(MLH1):c.303T>G (p.Gly101=) rs4647220 0.00002
NM_000249.4(MLH1):c.45G>C (p.Val15=) rs768409958 0.00002
NM_000249.4(MLH1):c.974G>A (p.Arg325Gln) rs63750268 0.00002
NM_000249.4(MLH1):c.1065C>T (p.Pro355=) rs1553650588 0.00001
NM_000249.4(MLH1):c.108T>C (p.Ile36=) rs730881747 0.00001
NM_000249.4(MLH1):c.1103C>T (p.Ser368Leu) rs201673334 0.00001
NM_000249.4(MLH1):c.1140C>T (p.Ala380=) rs786201611 0.00001
NM_000249.4(MLH1):c.1167G>A (p.Arg389=) rs772805767 0.00001
NM_000249.4(MLH1):c.1191G>A (p.Leu397=) rs35164771 0.00001
NM_000249.4(MLH1):c.1230C>T (p.Ala410=) rs764377126 0.00001
NM_000249.4(MLH1):c.1236C>T (p.Val412=) rs369576099 0.00001
NM_000249.4(MLH1):c.1359G>C (p.Lys453Asn) rs756099600 0.00001
NM_000249.4(MLH1):c.1401C>T (p.Ser467=) rs587778910 0.00001
NM_000249.4(MLH1):c.1421G>A (p.Arg474Gln) rs63751083 0.00001
NM_000249.4(MLH1):c.1446G>A (p.Val482=) rs1417379962 0.00001
NM_000249.4(MLH1):c.1452T>C (p.Asp484=) rs587778916 0.00001
NM_000249.4(MLH1):c.1460G>A (p.Arg487Gln) rs587778917 0.00001
NM_000249.4(MLH1):c.1512T>C (p.Thr504=) rs749683911 0.00001
NM_000249.4(MLH1):c.1519T>C (p.Leu507=) rs864622718 0.00001
NM_000249.4(MLH1):c.1533A>G (p.Glu511=) rs745906843 0.00001
NM_000249.4(MLH1):c.1647T>C (p.Leu549=) rs768770694 0.00001
NM_000249.4(MLH1):c.1665T>C (p.Leu555=) rs749204990 0.00001
NM_000249.4(MLH1):c.1902G>A (p.Gly634=) rs376866470 0.00001
NM_000249.4(MLH1):c.1990-6G>A rs117221851 0.00001
NM_000249.4(MLH1):c.1990-9T>C rs756846181 0.00001
NM_000249.4(MLH1):c.2013A>G (p.Glu671=) rs747503723 0.00001
NM_000249.4(MLH1):c.2034A>G (p.Lys678=) rs894876691 0.00001
NM_000249.4(MLH1):c.2082G>A (p.Glu694=) rs1057521441 0.00001
NM_000249.4(MLH1):c.2094A>G (p.Ser698=) rs786202433 0.00001
NM_000249.4(MLH1):c.2190T>C (p.Pro730=) rs1057521673 0.00001
NM_000249.4(MLH1):c.24T>A (p.Ile8=) rs748406142 0.00001
NM_000249.4(MLH1):c.30G>T (p.Arg10=) rs876660759 0.00001
NM_000249.4(MLH1):c.318C>T (p.Ser106=) rs63750297 0.00001
NM_000249.4(MLH1):c.351G>A (p.Thr117=) rs61751643 0.00001
NM_000249.4(MLH1):c.423A>G (p.Pro141=) rs201176051 0.00001
NM_000249.4(MLH1):c.483G>A (p.Thr161=) rs776402672 0.00001
NM_000249.4(MLH1):c.636C>T (p.Thr212=) rs138735345 0.00001
NM_000249.4(MLH1):c.63G>A (p.Ala21=) rs1553637274 0.00001
NM_000249.4(MLH1):c.762G>A (p.Lys254=) rs863224341 0.00001
NM_000249.4(MLH1):c.791-14T>C rs751254837 0.00001
NM_000249.4(MLH1):c.845C>G (p.Ala282Gly) rs63750360 0.00001
NM_000249.4(MLH1):c.885-5G>T rs267607802 0.00001
NM_000249.4(MLH1):c.990C>T (p.Ile330=) rs372578171 0.00001
NM_000249.3(MLH1):c.-107C>G rs587778886
NM_000249.3(MLH1):c.1558+3232_1558+3692delins2
NM_000249.4(MLH1):c.*158GATT[1] rs796807655
NM_000249.4(MLH1):c.*32CTT[1] rs193922366
NM_000249.4(MLH1):c.*7TTAT[1] rs779336928
NM_000249.4(MLH1):c.-14C>T rs730881744
NM_000249.4(MLH1):c.-15T>C rs764112241
NM_000249.4(MLH1):c.-8G>T rs761672073
NM_000249.4(MLH1):c.1003C>T (p.Leu335=) rs267607812
NM_000249.4(MLH1):c.1038+7del rs36118268
NM_000249.4(MLH1):c.1062C>G (p.Gly354=) rs730881748
NM_000249.4(MLH1):c.1062C>T (p.Gly354=) rs730881748
NM_000249.4(MLH1):c.1068T>C (p.Ser356=) rs1060504000
NM_000249.4(MLH1):c.1095T>C (p.Ser365=) rs746800098
NM_000249.4(MLH1):c.1136A>G (p.Tyr379Cys) rs143009528
NM_000249.4(MLH1):c.117-43_117-39del rs587778895
NM_000249.4(MLH1):c.1182T>C (p.Asp394=)
NM_000249.4(MLH1):c.1267A>G (p.Arg423Gly) rs1392665848
NM_000249.4(MLH1):c.1275G>A (p.Arg425=) rs1164834561
NM_000249.4(MLH1):c.1371A>G (p.Glu457=) rs878853776
NM_000249.4(MLH1):c.1410-6T>C rs779395647
NM_000249.4(MLH1):c.1419T>C (p.His473=)
NM_000249.4(MLH1):c.1420C>A (p.Arg474=) rs147939838
NM_000249.4(MLH1):c.1458C>T (p.Ser486=)
NM_000249.4(MLH1):c.159G>A (p.Glu53=) rs1060504012
NM_000249.4(MLH1):c.1618T>C (p.Leu540=) rs1448439825
NM_000249.4(MLH1):c.1620G>A (p.Leu540=) rs786202409
NM_000249.4(MLH1):c.1653C>T (p.Asn551=) rs587778936
NM_000249.4(MLH1):c.1732-7T>C rs745745276
NM_000249.4(MLH1):c.1732-9T>C rs267607857
NM_000249.4(MLH1):c.1755T>C (p.Leu585=) rs786202432
NM_000249.4(MLH1):c.1815A>G (p.Glu605=) rs767748815
NM_000249.4(MLH1):c.1818A>T (p.Gly606=) rs1057522427
NM_000249.4(MLH1):c.1824T>G (p.Ala608=) rs876659019
NM_000249.4(MLH1):c.1830C>T (p.Tyr610=) rs2125985283
NM_000249.4(MLH1):c.1853A>G (p.Lys618Arg) rs63750449
NM_000249.4(MLH1):c.1893T>C (p.Asp631=) rs786201289
NM_000249.4(MLH1):c.18G>A (p.Gly6=) rs786202312
NM_000249.4(MLH1):c.1960C>T (p.Pro654Ser) rs1559591314
NM_000249.4(MLH1):c.201G>T (p.Gly67=)
NM_000249.4(MLH1):c.2043T>C (p.Ala681=) rs768595157
NM_000249.4(MLH1):c.2058C>A (p.Ile686=) rs1242136178
NM_000249.4(MLH1):c.2059C>A (p.Arg687=) rs63751275
NM_000249.4(MLH1):c.2061G>A (p.Arg687=) rs1553664545
NM_000249.4(MLH1):c.208-6T>C
NM_000249.4(MLH1):c.2088C>G (p.Thr696=) rs1060504015
NM_000249.4(MLH1):c.2091C>T (p.Leu697=) rs536488280
NM_000249.4(MLH1):c.210A>G (p.Lys70=) rs63751191
NM_000249.4(MLH1):c.2131T>C (p.Ser711Pro) rs587781342
NM_000249.4(MLH1):c.2210A>T (p.Asp737Val) rs267607885
NM_000249.4(MLH1):c.307-10T>C rs572853043
NM_000249.4(MLH1):c.33G>A (p.Leu11=) rs1553637191
NM_000249.4(MLH1):c.342T>C (p.Thr114=) rs1057520553
NM_000249.4(MLH1):c.375A>C (p.Ala125=) rs1800144
NM_000249.4(MLH1):c.432C>T (p.Gly144=) rs1553642108
NM_000249.4(MLH1):c.454-15C>G rs372959218
NM_000249.4(MLH1):c.454-6G>T rs781238673
NM_000249.4(MLH1):c.479C>T (p.Ala160Val) rs63749924
NM_000249.4(MLH1):c.558C>T (p.His186=) rs63751050
NM_000249.4(MLH1):c.589-9G>T rs566497442
NM_000249.4(MLH1):c.597G>A (p.Glu199=) rs1425583191
NM_000249.4(MLH1):c.621A>G (p.Leu207=) rs770554901
NM_000249.4(MLH1):c.654C>T (p.Ser218=) rs876660372
NM_000249.4(MLH1):c.678A>T (p.Arg226=) rs786203360
NM_000249.4(MLH1):c.714A>G (p.Leu238=) rs1575480529
NM_000249.4(MLH1):c.716C>T (p.Ala239Val) rs1559534371
NM_000249.4(MLH1):c.717C>T (p.Ala239=) rs63749901
NM_000249.4(MLH1):c.723A>G (p.Lys241=) rs1057521605
NM_000249.4(MLH1):c.780C>T (p.Leu260=) rs587779038
NM_000249.4(MLH1):c.791-23del rs267607797
NM_000249.4(MLH1):c.836T>G (p.Val279Gly) rs1553646683
NM_000249.4(MLH1):c.885-21TC[2] rs267607804
NM_000249.4(MLH1):c.885-4A>G
NM_000249.4(MLH1):c.9C>T (p.Phe3=)

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