ClinVar Miner

List of variants in gene MSH6 reported as likely benign for Lynch syndrome

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Total variants: 57
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HGVS dbSNP gnomAD frequency
NM_000179.3(MSH6):c.457+13A>G rs1800933 0.00434
NM_000179.3(MSH6):c.3911G>A (p.Arg1304Lys) rs34625968 0.00253
NM_000179.3(MSH6):c.431G>T (p.Ser144Ile) rs3211299 0.00158
NM_000179.3(MSH6):c.1526T>C (p.Val509Ala) rs63751005 0.00067
NM_000179.3(MSH6):c.1508C>G (p.Ser503Cys) rs63750897 0.00059
NM_000179.3(MSH6):c.3488A>T (p.Glu1163Val) rs63750252 0.00032
NM_000179.3(MSH6):c.3217C>T (p.Pro1073Ser) rs142254875 0.00028
NM_000179.3(MSH6):c.4001+11_4001+15dup rs587779302 0.00019
NM_000179.3(MSH6):c.3160A>T (p.Ile1054Phe) rs267608075 0.00016
NM_000179.3(MSH6):c.1081C>T (p.Arg361Cys) rs587782651 0.00012
NM_000179.3(MSH6):c.1875C>T (p.Ser625=) rs63749886 0.00010
NM_000179.3(MSH6):c.660A>C (p.Glu220Asp) rs1800938 0.00009
NM_000179.3(MSH6):c.1019T>C (p.Phe340Ser) rs61753793 0.00006
NM_000179.3(MSH6):c.178T>C (p.Leu60=) rs35819209 0.00006
NM_000179.3(MSH6):c.3986C>T (p.Ser1329Leu) rs199594809 0.00006
NM_000179.3(MSH6):c.2239C>T (p.Leu747=) rs63751305 0.00005
NM_000179.3(MSH6):c.3801+5G>A rs201080919 0.00004
NM_000179.3(MSH6):c.1822A>G (p.Ile608Val) rs201613780 0.00003
NM_000179.3(MSH6):c.2319C>T (p.Leu773=) rs63749895 0.00003
NM_000179.3(MSH6):c.3426G>A (p.Thr1142=) rs747771350 0.00003
NM_000179.3(MSH6):c.957G>C (p.Thr319=) rs375210430 0.00002
NM_000179.3(MSH6):c.1168G>A (p.Asp390Asn) rs147737737 0.00001
NM_000179.3(MSH6):c.1403G>A (p.Arg468His) rs41295268 0.00001
NM_000179.3(MSH6):c.161G>C (p.Gly54Ala) rs63751098 0.00001
NM_000179.3(MSH6):c.194C>T (p.Ser65Leu) rs41294984 0.00001
NM_000179.3(MSH6):c.241G>A (p.Ala81Thr) rs587779239 0.00001
NM_000179.3(MSH6):c.2661T>G (p.Leu887=) rs267608069 0.00001
NM_000179.3(MSH6):c.2765G>A (p.Arg922Gln) rs752839086 0.00001
NM_000179.3(MSH6):c.3300G>A (p.Thr1100=) rs540252208 0.00001
MSH6:c.3647-51_3647-35del17 rs267607687
NM_000179.3(MSH6):c.1021T>G (p.Ser341Ala) rs1558660119
NM_000179.3(MSH6):c.1207C>A (p.Leu403Ile) rs876659223
NM_000179.3(MSH6):c.133G>T (p.Gly45Cys) rs978968846
NM_000179.3(MSH6):c.1400G>A (p.Gly467Asp) rs1558661547
NM_000179.3(MSH6):c.1667A>T (p.Tyr556Phe) rs63751312
NM_000179.3(MSH6):c.1770C>T (p.Pro590=) rs267608070
NM_000179.3(MSH6):c.189C>T (p.Ser63=) rs917331457
NM_000179.3(MSH6):c.1904G>A (p.Arg635Lys) rs1558663439
NM_000179.3(MSH6):c.2238T>C (p.Phe746=) rs1384756767
NM_000179.3(MSH6):c.2319C>A (p.Leu773=) rs63749895
NM_000179.3(MSH6):c.261-14C>T rs369366445
NM_000179.3(MSH6):c.3029C>T (p.Thr1010Ile) rs768925694
NM_000179.3(MSH6):c.3126A>C (p.Lys1042Asn) rs1558668218
NM_000179.3(MSH6):c.3207G>T (p.Gly1069=) rs267608074
NM_000179.3(MSH6):c.3964G>A (p.Glu1322Lys) rs1553333707
NM_000179.3(MSH6):c.4001+11_4001+35del rs878853743
NM_000179.3(MSH6):c.4001+2TAAC[2] rs267608132
NM_000179.3(MSH6):c.4002-10del rs59056100
NM_000179.3(MSH6):c.4018A>G (p.Ser1340Gly) rs1558395603
NM_000179.3(MSH6):c.4068_4071dup (p.Lys1358delinsAspTer) rs55740729
NM_000179.3(MSH6):c.458-5del rs587781955
NM_000179.3(MSH6):c.475G>A (p.Ala159Thr) rs1553411396
NM_000179.3(MSH6):c.511G>C (p.Glu171Gln) rs1558656518
NM_000179.3(MSH6):c.542A>C (p.Glu181Ala) rs1558656620
NM_000179.3(MSH6):c.911T>C (p.Val304Ala) rs1481054050
NM_000179.3(MSH6):c.971A>G (p.Lys324Arg) rs1558659961
NM_000179.3(MSH6):c.975A>G (p.Gln325=) rs193922345

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