ClinVar Miner

Variants studied for Malignant melanoma of skin

Coded as:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign protective total
0 279 0 0 0 1 280

Gene and significance breakdown #

Total genes and gene combinations: 37
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Gene or gene combination likely pathogenic protective total
TP53 92 0 92
CTNNB1 23 0 23
BRAF 19 0 19
PIK3CA 18 0 18
NRAS 14 0 14
HRAS, LRRC56 11 0 11
CDKN2A 10 0 10
FBXW7 10 0 10
MAP2K1 8 0 8
EZH2 6 0 6
B2M 5 0 5
IDH1 5 0 5
SF3B1 5 0 5
CDK4 4 0 4
CNOT9 4 0 4
CREBBP 4 0 4
ERBB2 4 0 4
PTEN 4 0 4
ARAF 3 0 3
GNAS 3 0 3
MTOR 3 0 3
MYC 3 0 3
RAC1 3 0 3
KIT 2 0 2
KRAS 2 0 2
MAP2K2 2 0 2
PIK3R1 2 0 2
RAF1 2 0 2
AKT1 1 0 1
BCL2L12, IRF3 1 0 1
CRNKL1 1 0 1
GNA11 1 0 1
KNSTRN 1 0 1
PPP6C 1 0 1
SF3B2 1 0 1
SLC45A2 0 1 1
STK19 1 0 1

Submitter and significance breakdown #

Total submitters: 2
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Submitter likely pathogenic protective total
Database of Curated Mutations (DoCM) 279 0 279
ClinVar Staff, National Center for Biotechnology Information (NCBI) 0 1 1

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