ClinVar Miner

List of variants reported as uncertain significance for Obesity

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Total variants: 99
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HGVS dbSNP gnomAD frequency
NM_005912.3(MC4R):c.307G>A (p.Val103Ile) rs2229616 0.01533
NM_005912.3(MC4R):c.751A>C (p.Ile251Leu) rs52820871 0.00774
NM_000939.4(POMC):c.18C>T (p.Cys6=) rs8192605 0.00562
NM_001035256.2(POMC):c.-203A>G rs139229417 0.00551
NM_005912.3(MC4R):c.-176A>G rs78877161 0.00473
NM_021969.3(NR0B2):c.473G>A (p.Ser158Asn) rs151014108 0.00413
NM_000939.4(POMC):c.261C>A (p.Phe87Leu) rs199636726 0.00346
NM_005912.3(MC4R):c.606C>A (p.Phe202Leu) rs138281308 0.00302
NM_000939.4(POMC):c.158A>G (p.Asp53Gly) rs28932470 0.00173
NM_000939.4(POMC):c.662A>G (p.Tyr221Cys) rs149540566 0.00096
NM_005912.3(MC4R):c.335C>T (p.Thr112Met) rs13447329 0.00065
NM_138711.6(PPARG):c.348T>C (p.Ala116=) rs147975759 0.00056
NM_005912.3(MC4R):c.677T>C (p.Ile226Thr) rs193922686 0.00037
NM_005912.3(MC4R):c.523G>A (p.Ala175Thr) rs121913563 0.00031
NM_001138.2(AGRP):c.264A>G (p.Val88=) rs145840661 0.00021
NM_000939.4(POMC):c.429C>G (p.His143Gln) rs201519174 0.00019
NM_138711.6(PPARG):c.391-3C>T rs370830238 0.00017
NM_005912.3(MC4R):c.-60C>G rs763156013 0.00016
NM_138711.6(PPARG):c.417G>A (p.Leu139=) rs41415646 0.00015
NM_000025.3(ADRB3):c.1013A>G (p.Asn338Ser) rs200277866 0.00014
NM_000025.3(ADRB3):c.452A>G (p.Lys151Arg) rs200133226 0.00014
NM_005912.3(MC4R):c.757G>A (p.Val253Ile) rs187152753 0.00014
NM_005912.2(MC4R):c.110A>T (p.Asp37Val) rs13447325 0.00013
NM_005912.3(MC4R):c.-386G>A rs756482194 0.00013
NM_005912.3(MC4R):c.806T>A (p.Ile269Asn) rs79783591 0.00011
NM_005912.3(MC4R):c.972C>T (p.Gly324=) rs150448918 0.00011
NM_000939.4(POMC):c.-20-906C>T rs886055855 0.00010
NM_003356.4(UCP3):c.922C>T (p.Arg308Trp) rs763155375 0.00009
NM_003356.4(UCP3):c.490G>A (p.Asp164Asn) rs367566750 0.00008
NM_005912.3(MC4R):c.-220G>A rs772697287 0.00008
NM_005912.3(MC4R):c.380C>T (p.Ser127Leu) rs13447331 0.00008
NM_005912.3(MC4R):c.405A>C (p.Ala135=) rs140773238 0.00008
NM_000939.4(POMC):c.116C>T (p.Thr39Met) rs200370644 0.00007
NM_003356.4(UCP3):c.202A>G (p.Met68Val) rs370829405 0.00006
NM_004291.4(CARTPT):c.183G>C (p.Leu61Phe) rs121909065 0.00006
NM_005912.3(MC4R):c.-295A>G rs926966481 0.00006
NM_005912.3(MC4R):c.21T>C (p.Arg7=) rs760074702 0.00005
NM_005912.3(MC4R):c.913C>T (p.Arg305Trp) rs549442687 0.00005
NM_000939.4(POMC):c.638C>T (p.Ala213Val) rs757423347 0.00004
NM_003356.4(UCP3):c.386T>C (p.Met129Thr) rs1047063799 0.00004
NM_005912.3(MC4R):c.534G>A (p.Thr178=) rs146056286 0.00004
NM_138711.6(PPARG):c.198C>T (p.Asp66=) rs753817211 0.00004
NM_000939.4(POMC):c.*120A>G rs886055853 0.00003
NM_000939.4(POMC):c.498C>T (p.Asp166=) rs760352559 0.00003
NM_005912.3(MC4R):c.-121G>A rs541962206 0.00003
NM_005912.3(MC4R):c.776C>T (p.Ala259Val) rs762825773 0.00003
NM_138711.6(PPARG):c.1224A>G (p.Gln408=) rs28763894 0.00003
NM_138711.6(PPARG):c.145G>A (p.Glu49Lys) rs777334819 0.00003
NM_003356.4(UCP3):c.274G>A (p.Ala92Thr) rs192655642 0.00002
NM_005912.3(MC4R):c.15C>T (p.Thr5=) rs199862517 0.00002
NM_138711.6(PPARG):c.393T>C (p.Gly131=) rs201126401 0.00002
NM_000939.4(POMC):c.491C>T (p.Ala164Val) rs773522618 0.00001
NM_000939.4(POMC):c.4C>T (p.Pro2Ser) rs752925315 0.00001
NM_000939.4(POMC):c.801G>A (p.Glu267=) rs779850714 0.00001
NM_003356.4(UCP3):c.365C>T (p.Ala122Val) rs773117397 0.00001
NM_005912.3(MC4R):c.-263A>G rs1915374953 0.00001
NM_005912.3(MC4R):c.-375G>T rs886054080 0.00001
NM_005912.3(MC4R):c.161T>C (p.Leu54Pro) rs376439188 0.00001
NM_005912.3(MC4R):c.373A>G (p.Ile125Val) rs1598932263 0.00001
NM_005912.3(MC4R):c.645G>A (p.Met215Ile) rs768687497 0.00001
NM_005912.3(MC4R):c.821A>G (p.Asn274Ser) rs121913561 0.00001
NM_005912.3(MC4R):c.929G>A (p.Arg310Lys) rs1429906794 0.00001
NM_138711.6(PPARG):c.629G>A (p.Arg210Gln) rs150296212 0.00001
NC_000003.12:g.41359534_41821951del
NM_000939.4(POMC):c.-20-904T>C rs886055854
NM_000939.4(POMC):c.283A>G (p.Ser95Gly) rs550376110
NM_000939.4(POMC):c.394C>G (p.Pro132Ala) rs8192606
NM_000939.4(POMC):c.474G>T (p.Lys158Asn) rs373721473
NM_000939.4(POMC):c.642G>A (p.Glu214=) rs1671345551
NM_001035256.2(POMC):c.-263C>A rs556369764
NM_001035256.2(POMC):c.297_298ins90 (p.?)
NM_001394028.1(PYY):c.185A>C (p.Gln62Pro) rs267606994
NM_001709.5(BDNF):c.5C>T (p.Thr2Ile) rs8192466
NM_004176.5(SREBF1):c.2605G>A (p.Val869Ile)
NM_005068.3(SIM1):c.817G>A (p.Asp273Asn) rs2114540224
NM_005912.3(MC4R):c.-161C>T rs886054079
NM_005912.3(MC4R):c.-18T>C rs886054077
NM_005912.3(MC4R):c.-359C>A rs982798124
NM_005912.3(MC4R):c.-360G>A rs530787706
NM_005912.3(MC4R):c.-59G>A rs750662653
NM_005912.3(MC4R):c.-64G>A rs1485034384
NM_005912.3(MC4R):c.-66C>T rs886054078
NM_005912.3(MC4R):c.201G>A (p.Val67=) rs886054076
NM_005912.3(MC4R):c.63_64del (p.Tyr21_Arg22delinsTer) rs770293321
NM_005912.3(MC4R):c.655G>T (p.Ala219Ser) rs1915344558
NM_005912.3(MC4R):c.815C>G (p.Pro272Arg) rs1915338291
NM_005912.3(MC4R):c.836G>A (p.Cys279Tyr) rs1915337291
NM_005912.3(MC4R):c.914G>A (p.Arg305Gln) rs775382722
NM_005912.3(MC4R):c.949A>T (p.Ile317Phe) rs778685158
NM_006180.6(NTRK2):c.2000C>G (p.Ser667Trp) rs777251032
NM_016362.5(GHRL):c.255del (p.Lys85fs) rs1044457750
NM_019888.3(MC3R):c.134T>C (p.Phe45Ser)
NM_019888.3(MC3R):c.37A>G (p.Thr13Ala)
NM_021969.3(NR0B2):c.528C>A (p.Asn176Lys)
NM_021969.3(NR0B2):c.712C>T (p.Arg238Cys) rs777140276
NM_138711.6(PPARG):c.1116C>A (p.Phe372Leu) rs886057902
NM_138711.6(PPARG):c.1419C>T (p.Asp473=) rs886057903
NM_138711.6(PPARG):c.431A>G (p.Asp144Gly) rs1211829538
NM_138711.6(PPARG):c.56A>C (p.Asp19Ala) rs762280243

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