ClinVar Miner

Variants studied for Ovarian Neoplasms

Coded as:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
258 178 0 0 0 2 436

Gene and significance breakdown #

Total genes and gene combinations: 30
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Gene or gene combination pathogenic likely pathogenic not provided total
TP53 87 137 0 224
BRCA1 64 4 0 68
BRCA2 30 1 0 31
PTEN 14 9 0 22
PIK3CA 8 7 0 14
FANCM 8 0 0 8
RAD51C 6 2 0 8
PALB2 3 4 0 7
KRAS 6 0 0 6
MAP3K1 4 1 0 5
MSH6 4 1 0 5
CTNNB1 0 4 0 4
RAD51D, RAD51L3-RFFL 2 2 0 4
ATM 3 0 0 3
BRAF 2 1 0 3
BRIP1 2 1 0 3
CHEK1 2 1 0 3
MSH2 3 0 0 3
ATM, C11orf65 1 1 0 2
CHEK2 2 0 0 2
MRE11 2 0 0 2
ABCB1 0 0 1 1
ABCG2 0 0 1 1
ABRAXAS1 1 0 0 1
BARD1 0 1 0 1
BUB1B, BUB1B-PAK6 1 0 0 1
NBN 1 0 0 1
PMS2 1 0 0 1
RAD50 0 1 0 1
XRCC2 1 0 0 1

Submitter and significance breakdown #

Total submitters: 2
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Submitter pathogenic likely pathogenic not provided total
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne 246 173 0 419
Database of Curated Mutations (DoCM) 17 5 2 24

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