ClinVar Miner

List of variants in gene BRAF reported as likely benign for RASopathy

Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:
Total variants: 300
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HGVS dbSNP gnomAD frequency
NM_004333.6(BRAF):c.240+18A>G rs368584855 0.00017
NM_004333.6(BRAF):c.1860+16A>G rs368859030 0.00016
NM_004333.6(BRAF):c.483G>C (p.Leu161=) rs61730029 0.00016
NM_004333.6(BRAF):c.1141-12A>G rs375704079 0.00014
NM_004333.6(BRAF):c.723G>A (p.Thr241=) rs369182143 0.00013
NM_004333.6(BRAF):c.1632T>C (p.Ile544=) rs149702741 0.00010
NM_004333.6(BRAF):c.1993-11T>C rs750297886 0.00009
NM_004333.6(BRAF):c.2128-17T>C rs769351098 0.00009
NM_004333.6(BRAF):c.399A>G (p.Ser133=) rs397507463 0.00009
NM_004333.6(BRAF):c.1694+13C>T rs368578780 0.00007
NM_004333.6(BRAF):c.1433-5T>C rs587780861 0.00006
NM_004333.6(BRAF):c.505-12A>G rs377433501 0.00006
NM_004333.6(BRAF):c.608+14G>A rs752604323 0.00006
NM_004333.6(BRAF):c.92C>G (p.Ala31Gly) rs397516906 0.00006
NM_004333.6(BRAF):c.1992+8T>C rs753545284 0.00005
NM_004333.6(BRAF):c.1993-13T>C rs775808846 0.00005
NM_004333.6(BRAF):c.2196C>G (p.Ser732=) rs142592480 0.00005
NM_004333.6(BRAF):c.1150A>G (p.Arg384Gly) rs545495379 0.00004
NM_004333.6(BRAF):c.1993-9T>G rs971451154 0.00004
NM_004333.6(BRAF):c.915G>A (p.Ala305=) rs145675911 0.00004
NM_004333.6(BRAF):c.114T>C (p.Ala38=) rs779587891 0.00003
NM_004333.6(BRAF):c.1314+17T>C rs1057524397 0.00003
NM_004333.6(BRAF):c.1517+13G>A rs572300688 0.00003
NM_004333.6(BRAF):c.2128-10_2128-9insC rs758588300 0.00003
NM_004333.6(BRAF):c.2128-15T>C rs763538892 0.00003
NM_004333.6(BRAF):c.2128-20T>C rs1280793787 0.00003
NM_004333.6(BRAF):c.2136C>T (p.Ala712=) rs377165711 0.00003
NM_004333.6(BRAF):c.240+11G>A rs730880379 0.00003
NM_004333.6(BRAF):c.608+18C>T rs764984248 0.00003
NM_004333.6(BRAF):c.*7T>C rs727502903 0.00002
NM_004333.6(BRAF):c.138+17C>G rs756400234 0.00002
NM_004333.6(BRAF):c.1401A>G (p.Ser467=) rs776001588 0.00002
NM_004333.6(BRAF):c.1433-18G>A rs763267814 0.00002
NM_004333.6(BRAF):c.1518-7T>C rs199745091 0.00002
NM_004333.6(BRAF):c.1518-9T>G rs758498850 0.00002
NM_004333.6(BRAF):c.357C>T (p.Thr119=) rs552456345 0.00002
NM_004333.6(BRAF):c.622A>G (p.Ile208Val) rs727504571 0.00002
NM_004333.6(BRAF):c.102G>C (p.Ala34=) rs1372257667 0.00001
NM_004333.6(BRAF):c.1178-10A>G rs527835644 0.00001
NM_004333.6(BRAF):c.1236C>T (p.Asn412=) rs397516888 0.00001
NM_004333.6(BRAF):c.1305G>A (p.Arg435=) rs763771673 0.00001
NM_004333.6(BRAF):c.1314+12T>C rs765090629 0.00001
NM_004333.6(BRAF):c.1338G>A (p.Ser446=) rs765215499 0.00001
NM_004333.6(BRAF):c.1347T>C (p.Asp449=) rs397516889 0.00001
NM_004333.6(BRAF):c.139-9del rs1487772115 0.00001
NM_004333.6(BRAF):c.1572A>G (p.Gln524=) rs552471935 0.00001
NM_004333.6(BRAF):c.1602C>T (p.Gly534=) rs761240860 0.00001
NM_004333.6(BRAF):c.1742-10T>C rs730880411 0.00001
NM_004333.6(BRAF):c.1797A>G (p.Thr599=) rs1431556127 0.00001
NM_004333.6(BRAF):c.1818G>A (p.Gly606=) rs1797931923 0.00001
NM_004333.6(BRAF):c.1848C>A (p.Ser616=) rs752115982 0.00001
NM_004333.6(BRAF):c.1861-12A>G rs1397986324 0.00001
NM_004333.6(BRAF):c.193T>C (p.Leu65=) rs866875749 0.00001
NM_004333.6(BRAF):c.1992+15C>T rs766089848 0.00001
NM_004333.6(BRAF):c.1993-10C>A rs1034603754 0.00001
NM_004333.6(BRAF):c.2019C>T (p.Tyr673=) rs759664527 0.00001
NM_004333.6(BRAF):c.2082A>G (p.Ala694=) rs375174370 0.00001
NM_004333.6(BRAF):c.2127+7A>G rs371857758 0.00001
NM_004333.6(BRAF):c.2128-10T>C rs397516898 0.00001
NM_004333.6(BRAF):c.2160A>G (p.Ser720=) rs915698949 0.00001
NM_004333.6(BRAF):c.2229T>C (p.Phe743=) rs397516901 0.00001
NM_004333.6(BRAF):c.258C>A (p.Thr86=) rs760454617 0.00001
NM_004333.6(BRAF):c.298T>C (p.Leu100=) rs761709697 0.00001
NM_004333.6(BRAF):c.315C>T (p.Asn105=) rs768536776 0.00001
NM_004333.6(BRAF):c.459A>G (p.Gln153=) rs1476241098 0.00001
NM_004333.6(BRAF):c.567T>C (p.Gly189=) rs1057523903 0.00001
NM_004333.6(BRAF):c.63G>A (p.Gly21=) rs1158725219 0.00001
NM_004333.6(BRAF):c.675A>G (p.Glu225=) rs755993280 0.00001
NM_004333.6(BRAF):c.750T>C (p.Phe250=) rs754568893 0.00001
NM_004333.6(BRAF):c.81C>G (p.Ala27=) rs1330565982 0.00001
NM_004333.6(BRAF):c.81C>T (p.Ala27=) rs1330565982 0.00001
NM_004333.6(BRAF):c.87C>T (p.Ala29=) rs1344877993 0.00001
NM_004333.6(BRAF):c.951C>A (p.Ser317=) rs755298519 0.00001
NM_004333.6(BRAF):c.957C>T (p.Ser319=) rs754029526 0.00001
NM_004333.6(BRAF):c.969G>A (p.Ser323=) rs768134774 0.00001
NM_004333.6(BRAF):c.976A>G (p.Ile326Val) rs775040765 0.00001
NC_000007.14:g.140783126A>G rs397516887
NM_004333.6(BRAF):c.105C>G (p.Ala35=) rs1320140960
NM_004333.6(BRAF):c.105C>T (p.Ala35=)
NM_004333.6(BRAF):c.111G>A (p.Ser37=) rs727502906
NM_004333.6(BRAF):c.111G>C (p.Ser37=)
NM_004333.6(BRAF):c.1141-12A>C rs375704079
NM_004333.6(BRAF):c.1141-18A>G
NM_004333.6(BRAF):c.1141-4G>A rs1256078767
NM_004333.6(BRAF):c.1161A>G (p.Gly387=) rs2129031568
NM_004333.6(BRAF):c.1177+11A>C
NM_004333.6(BRAF):c.1177+13T>C
NM_004333.6(BRAF):c.1177+15C>A
NM_004333.6(BRAF):c.1177+15C>T rs1801515098
NM_004333.6(BRAF):c.1177+18G>A
NM_004333.6(BRAF):c.1177+18G>T
NM_004333.6(BRAF):c.1177+8G>C
NM_004333.6(BRAF):c.1178-10A>T
NM_004333.6(BRAF):c.1178-7A>G
NM_004333.6(BRAF):c.1182A>C (p.Ser394=)
NM_004333.6(BRAF):c.1200T>A (p.Ala400=)
NM_004333.6(BRAF):c.1203C>A (p.Thr401=) rs370130654
NM_004333.6(BRAF):c.1203C>T (p.Thr401=) rs370130654
NM_004333.6(BRAF):c.1206C>A (p.Pro402=) rs201758035
NM_004333.6(BRAF):c.1206C>T (p.Pro402=) rs201758035
NM_004333.6(BRAF):c.1230A>C (p.Leu410=)
NM_004333.6(BRAF):c.126C>G (p.Ala42=)
NM_004333.6(BRAF):c.1293C>T (p.Ser431=) rs1482623454
NM_004333.6(BRAF):c.1302C>T (p.Asp434=)
NM_004333.6(BRAF):c.1314+10T>C
NM_004333.6(BRAF):c.1314+13_1314+15del rs771893698
NM_004333.6(BRAF):c.1314+14A>G
NM_004333.6(BRAF):c.1314+9A>T
NM_004333.6(BRAF):c.1315-12G>C
NM_004333.6(BRAF):c.1315-13T>G
NM_004333.6(BRAF):c.1315-9T>C
NM_004333.6(BRAF):c.132G>C (p.Pro44=) rs889134706
NM_004333.6(BRAF):c.1330C>A (p.Arg444=) rs121913371
NM_004333.6(BRAF):c.1335C>T (p.Asp445=)
NM_004333.6(BRAF):c.1365G>T (p.Gly455=)
NM_004333.6(BRAF):c.1368G>A (p.Gln456=) rs767473452
NM_004333.6(BRAF):c.138+16A>C
NM_004333.6(BRAF):c.138+16A>G
NM_004333.6(BRAF):c.139-16T>C rs1809013029
NM_004333.6(BRAF):c.1392A>G (p.Gly464=)
NM_004333.6(BRAF):c.1398A>G (p.Gly466=)
NM_004333.6(BRAF):c.141G>T (p.Val47=)
NM_004333.6(BRAF):c.1422A>C (p.Gly474=)
NM_004333.6(BRAF):c.1432+17G>T rs62487919
NM_004333.6(BRAF):c.1432+17_1432+19del rs777363183
NM_004333.6(BRAF):c.1433-11T>A
NM_004333.6(BRAF):c.1433-15A>G rs2129019763
NM_004333.6(BRAF):c.1433-4T>G
NM_004333.6(BRAF):c.1433-7C>T rs1057522055
NM_004333.6(BRAF):c.1433-9G>A
NM_004333.6(BRAF):c.1443A>C (p.Ala481=) rs2129019701
NM_004333.6(BRAF):c.1491C>T (p.Ala497=) rs2129019551
NM_004333.6(BRAF):c.1500T>C (p.Asn500=)
NM_004333.6(BRAF):c.150C>T (p.Ile50=)
NM_004333.6(BRAF):c.1517+9G>A rs956390000
NM_004333.6(BRAF):c.1517+9G>C rs956390000
NM_004333.6(BRAF):c.1518-15C>T
NM_004333.6(BRAF):c.1518-17C>A rs1800405621
NM_004333.6(BRAF):c.1518-17C>T
NM_004333.6(BRAF):c.1518-20T>C
NM_004333.6(BRAF):c.1518-5T>C rs940384157
NM_004333.6(BRAF):c.1518-6G>T rs1487604495
NM_004333.6(BRAF):c.1521A>G (p.Lys507=)
NM_004333.6(BRAF):c.1530T>C (p.His510=) rs1800401202
NM_004333.6(BRAF):c.1533G>A (p.Val511=) rs1345884129
NM_004333.6(BRAF):c.1536T>C (p.Asn512=)
NM_004333.6(BRAF):c.1539C>A (p.Ile513=)
NM_004333.6(BRAF):c.1542A>G (p.Leu514=) rs2129018564
NM_004333.6(BRAF):c.1554C>G (p.Gly518=)
NM_004333.6(BRAF):c.1569A>G (p.Pro523=) rs759843625
NM_004333.6(BRAF):c.1587C>T (p.Thr529=)
NM_004333.6(BRAF):c.15C>T (p.Ser5=) rs1253814897
NM_004333.6(BRAF):c.1617C>T (p.His539=)
NM_004333.6(BRAF):c.1694+11T>C
NM_004333.6(BRAF):c.1694+9C>G
NM_004333.6(BRAF):c.1695-16A>T
NM_004333.6(BRAF):c.1719C>A (p.Ile573=) rs2128999629
NM_004333.6(BRAF):c.1731C>G (p.Leu577=)
NM_004333.6(BRAF):c.1741+14A>T
NM_004333.6(BRAF):c.1741+15A>C rs750735369
NM_004333.6(BRAF):c.1741+16T>C
NM_004333.6(BRAF):c.1741+17T>C
NM_004333.6(BRAF):c.1741+19G>T
NM_004333.6(BRAF):c.1741+9C>T
NM_004333.6(BRAF):c.1742-10T>G rs730880411
NM_004333.6(BRAF):c.1742-12A>G
NM_004333.6(BRAF):c.1767A>C (p.Thr589=) rs1797942787
NM_004333.6(BRAF):c.1789C>T (p.Leu597=) rs121913369
NM_004333.6(BRAF):c.1800G>C (p.Val600=)
NM_004333.6(BRAF):c.1837T>C (p.Leu613=)
NM_004333.6(BRAF):c.1860+10G>A
NM_004333.6(BRAF):c.1860+15T>A rs1276648324
NM_004333.6(BRAF):c.1860+8T>C
NM_004333.6(BRAF):c.1861-15T>C
NM_004333.6(BRAF):c.1861-15T>G
NM_004333.6(BRAF):c.1861-17T>A
NM_004333.6(BRAF):c.1861-18C>G
NM_004333.6(BRAF):c.1861-7C>G
NM_004333.6(BRAF):c.1920T>C (p.Tyr640=)
NM_004333.6(BRAF):c.1932T>C (p.Ile644=)
NM_004333.6(BRAF):c.1944A>G (p.Glu648=)
NM_004333.6(BRAF):c.1945T>C (p.Leu649=)
NM_004333.6(BRAF):c.1971A>C (p.Ser657=)
NM_004333.6(BRAF):c.1980C>T (p.Asn660=)
NM_004333.6(BRAF):c.1984A>C (p.Arg662=) rs2128994297
NM_004333.6(BRAF):c.1986G>A (p.Arg662=)
NM_004333.6(BRAF):c.1992+20T>C rs2128994223
NM_004333.6(BRAF):c.1992+8T>G
NM_004333.6(BRAF):c.1993-10C>G
NM_004333.6(BRAF):c.1993-10C>T
NM_004333.6(BRAF):c.1993-20C>A
NM_004333.6(BRAF):c.1993-7T>G
NM_004333.6(BRAF):c.1993-8C>T
NM_004333.6(BRAF):c.2010A>T (p.Gly670=)
NM_004333.6(BRAF):c.2070G>A (p.Lys690=)
NM_004333.6(BRAF):c.2109G>A (p.Glu703=)
NM_004333.6(BRAF):c.2127+11G>A
NM_004333.6(BRAF):c.2127+19C>T rs1796757619
NM_004333.6(BRAF):c.2127+9A>G rs1338359452
NM_004333.6(BRAF):c.2128-13T>C
NM_004333.6(BRAF):c.2128-16C>T rs368721021
NM_004333.6(BRAF):c.2128-16_2128-14del rs1585932359
NM_004333.6(BRAF):c.2128-16_2128-15delinsTC rs2130870208
NM_004333.6(BRAF):c.2128-16_2128-7del rs766844227
NM_004333.6(BRAF):c.2128-20_2128-17del
NM_004333.6(BRAF):c.2128-27_2128-18del rs774138098
NM_004333.6(BRAF):c.2128-27_2128-19del rs761539834
NM_004333.6(BRAF):c.2128-27_2128-7del rs754390169
NM_004333.6(BRAF):c.2128-44_2128-18del rs1562931259
NM_004333.6(BRAF):c.2128-4G>T rs956143558
NM_004333.6(BRAF):c.2128-5T>C
NM_004333.6(BRAF):c.2128-6_2128-5dup rs373442098
NM_004333.6(BRAF):c.2128-6_2128-5insTTTTTTTTTC
NM_004333.6(BRAF):c.2133C>T (p.Leu711=) rs2130869623
NM_004333.6(BRAF):c.2142T>C (p.Ile714=) rs1554388024
NM_004333.6(BRAF):c.2157C>T (p.Arg719=) rs1796236915
NM_004333.6(BRAF):c.2190A>G (p.Glu730=) rs1585931446
NM_004333.6(BRAF):c.21C>A (p.Gly7=) rs1196182256
NM_004333.6(BRAF):c.21C>T (p.Gly7=) rs1196182256
NM_004333.6(BRAF):c.2205G>A (p.Arg735=) rs2130868564
NM_004333.6(BRAF):c.2253A>G (p.Pro751=)
NM_004333.6(BRAF):c.2271A>T (p.Ala757=)
NM_004333.6(BRAF):c.2277A>T (p.Gly759=)
NM_004333.6(BRAF):c.240+13G>A
NM_004333.6(BRAF):c.240+15A>G rs765731817
NM_004333.6(BRAF):c.240+20A>G
NM_004333.6(BRAF):c.241-13C>T
NM_004333.6(BRAF):c.249A>G (p.Glu83=)
NM_004333.6(BRAF):c.24T>G (p.Gly8=)
NM_004333.6(BRAF):c.276C>T (p.Leu92=)
NM_004333.6(BRAF):c.279A>G (p.Gln93=) rs150050723
NM_004333.6(BRAF):c.288A>G (p.Glu96=)
NM_004333.6(BRAF):c.291A>G (p.Gln97=)
NM_004333.6(BRAF):c.30C>T (p.Gly10=)
NM_004333.6(BRAF):c.339C>T (p.Ser113=) rs777971698
NM_004333.6(BRAF):c.33C>T (p.Gly11=)
NM_004333.6(BRAF):c.342T>C (p.Ser114=)
NM_004333.6(BRAF):c.345A>G (p.Ala115=)
NM_004333.6(BRAF):c.345A>T (p.Ala115=)
NM_004333.6(BRAF):c.348A>T (p.Ser116=)
NM_004333.6(BRAF):c.349A>G (p.Met117Val)
NM_004333.6(BRAF):c.363A>G (p.Thr121=) rs1586339911
NM_004333.6(BRAF):c.411T>G (p.Val137=) rs1586339662
NM_004333.6(BRAF):c.42G>A (p.Pro14=)
NM_004333.6(BRAF):c.441C>T (p.Ser147=)
NM_004333.6(BRAF):c.468C>T (p.Ile156=) rs1562985327
NM_004333.6(BRAF):c.471T>A (p.Val157=) rs748370093
NM_004333.6(BRAF):c.504+18T>C
NM_004333.6(BRAF):c.504+7C>T
NM_004333.6(BRAF):c.504+8A>C
NM_004333.6(BRAF):c.505-20A>G
NM_004333.6(BRAF):c.516G>A (p.Arg172=)
NM_004333.6(BRAF):c.531C>T (p.Val177=)
NM_004333.6(BRAF):c.573C>T (p.Ile191=)
NM_004333.6(BRAF):c.579G>A (p.Glu193=)
NM_004333.6(BRAF):c.57C>T (p.Phe19=)
NM_004333.6(BRAF):c.608+19G>A rs200908826
NM_004333.6(BRAF):c.608+19G>C rs200908826
NM_004333.6(BRAF):c.609-13C>G
NM_004333.6(BRAF):c.609-18T>G
NM_004333.6(BRAF):c.609-9A>G
NM_004333.6(BRAF):c.651T>C (p.Leu217=)
NM_004333.6(BRAF):c.679T>C (p.Leu227=) rs2129047891
NM_004333.6(BRAF):c.68T>A (p.Met23Lys) rs746778122
NM_004333.6(BRAF):c.696T>C (p.Leu232=)
NM_004333.6(BRAF):c.702A>G (p.Thr234=)
NM_004333.6(BRAF):c.711+7A>T
NM_004333.6(BRAF):c.712-11T>C
NM_004333.6(BRAF):c.712-18_712-17del
NM_004333.6(BRAF):c.712-19G>C
NM_004333.6(BRAF):c.712-21_712-20del rs764713879
NM_004333.6(BRAF):c.72G>A (p.Glu24=) rs587778114
NM_004333.6(BRAF):c.738A>G (p.Ala246=) rs1586213511
NM_004333.6(BRAF):c.75C>G (p.Pro25=)
NM_004333.6(BRAF):c.75C>T (p.Pro25=)
NM_004333.6(BRAF):c.774T>A (p.Gly258=)
NM_004333.6(BRAF):c.789A>C (p.Thr263=) rs986525858
NM_004333.6(BRAF):c.789A>G (p.Thr263=)
NM_004333.6(BRAF):c.816T>C (p.Cys272=)
NM_004333.6(BRAF):c.822A>C (p.Thr274=)
NM_004333.6(BRAF):c.822A>G (p.Thr274=) rs779713260
NM_004333.6(BRAF):c.831A>C (p.Pro277=) rs2129044278
NM_004333.6(BRAF):c.84C>G (p.Gly28=)
NM_004333.6(BRAF):c.855A>G (p.Gln285=) rs376575252
NM_004333.6(BRAF):c.858T>G (p.Leu286=) rs758553809
NM_004333.6(BRAF):c.860+17T>C
NM_004333.6(BRAF):c.915G>T (p.Ala305=)
NM_004333.6(BRAF):c.918C>G (p.Ser306=) rs794727865
NM_004333.6(BRAF):c.933C>A (p.Ala311=)
NM_004333.6(BRAF):c.93C>G (p.Ala31=)
NM_004333.6(BRAF):c.93C>T (p.Ala31=)
NM_004333.6(BRAF):c.957C>G (p.Ser319=) rs754029526
NM_004333.6(BRAF):c.960A>G (p.Ala320=)
NM_004333.6(BRAF):c.963C>T (p.Pro321=)
NM_004333.6(BRAF):c.969G>T (p.Ser323=) rs768134774
NM_004333.6(BRAF):c.972C>T (p.Asp324=)
NM_004333.6(BRAF):c.975T>C (p.Ser325=)
NM_004333.6(BRAF):c.980+17G>C rs2129043563
NM_004333.6(BRAF):c.980+20C>G
NM_004333.6(BRAF):c.99C>G (p.Ala33=)

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