ClinVar Miner

List of variants in gene SOS1 reported as benign for RASopathy

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Gene type:
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Total variants: 54
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HGVS dbSNP gnomAD frequency
NM_005633.4(SOS1):c.195A>C (p.Arg65=) rs7609455 0.03809
NM_005633.4(SOS1):c.1203-20T>C rs112906251 0.01058
NM_005633.4(SOS1):c.1964C>T (p.Pro655Leu) rs56219475 0.00787
NM_005633.4(SOS1):c.1074+5G>C rs145155424 0.00655
NM_005633.4(SOS1):c.2167+6T>G rs186640807 0.00510
NM_005633.4(SOS1):c.345+15C>T rs75937422 0.00407
NM_005633.4(SOS1):c.2997T>C (p.Asn999=) rs145364368 0.00352
NM_005633.4(SOS1):c.2673+14T>C rs183998234 0.00304
NM_005633.4(SOS1):c.2122G>A (p.Ala708Thr) rs140811086 0.00280
NM_005633.4(SOS1):c.570C>T (p.Asp190=) rs55980502 0.00233
NM_005633.4(SOS1):c.3081+13A>G rs189695571 0.00223
NM_005633.4(SOS1):c.1230G>A (p.Gln410=) rs141390073 0.00217
NM_005633.4(SOS1):c.3032A>G (p.Asn1011Ser) rs8192671 0.00164
NM_005633.4(SOS1):c.2988G>A (p.Pro996=) rs35462677 0.00156
NM_005633.4(SOS1):c.213+16T>C rs150536159 0.00128
NM_005633.4(SOS1):c.2238T>C (p.Asn746=) rs75877625 0.00084
NM_005633.4(SOS1):c.3391+7A>G rs201982464 0.00066
NM_005633.4(SOS1):c.749T>C (p.Val250Ala) rs139290271 0.00054
NM_005633.4(SOS1):c.2371C>A (p.Leu791Ile) rs142004123 0.00053
NM_005633.4(SOS1):c.2760G>A (p.Arg920=) rs149092581 0.00051
NM_005633.4(SOS1):c.345+12_345+13dup rs397517167 0.00050
NM_005633.4(SOS1):c.1203-13T>A rs145166996 0.00049
NM_005633.4(SOS1):c.1770G>A (p.Glu590=) rs553331572 0.00022
NM_005633.4(SOS1):c.1705C>G (p.Leu569Val) rs200786705 0.00019
NM_005633.4(SOS1):c.*4C>T rs188849286 0.00018
NM_005633.4(SOS1):c.2964+17A>G rs201906525 0.00018
NM_005633.4(SOS1):c.3072C>T (p.Leu1024=) rs558386297 0.00013
NM_005633.4(SOS1):c.553A>G (p.Ile185Val) rs143962515 0.00010
NM_005633.4(SOS1):c.2010G>C (p.Leu670Phe) rs200712930 0.00008
NM_005633.4(SOS1):c.3515T>C (p.Met1172Thr) rs537874171 0.00006
NM_005633.4(SOS1):c.115G>A (p.Glu39Lys) rs375934353 0.00004
NM_005633.4(SOS1):c.2953T>G (p.Ser985Ala) rs754676663 0.00004
NM_005633.4(SOS1):c.3350A>G (p.Asn1117Ser) rs754314057 0.00004
NM_005633.4(SOS1):c.3737A>G (p.Asn1246Ser) rs374110460 0.00004
NM_005633.4(SOS1):c.3859A>G (p.Ile1287Val) rs760917490 0.00004
NM_005633.4(SOS1):c.141T>C (p.Tyr47=) rs201649682 0.00003
NM_005633.4(SOS1):c.510+9C>G rs553448375 0.00003
NM_005633.4(SOS1):c.1772A>G (p.Asn591Ser) rs757213444 0.00002
NM_005633.4(SOS1):c.3838C>A (p.Gln1280Lys) rs548519280 0.00002
NM_005633.4(SOS1):c.979A>G (p.Ile327Val) rs758546951 0.00002
NM_005633.4(SOS1):c.1574T>C (p.Ile525Thr) rs146722878 0.00001
NM_005633.4(SOS1):c.2158A>G (p.Thr720Ala) rs367634525 0.00001
NM_005633.4(SOS1):c.3274G>A (p.Ala1092Thr) rs373948887 0.00001
NM_005633.4(SOS1):c.3552T>G (p.Pro1184=) rs200485215 0.00001
NM_005633.4(SOS1):c.3610A>G (p.Ile1204Val) rs374497013 0.00001
NM_005633.3:c.1-36_1-34delGCC
NM_005633.4(SOS1):c.1113A>G (p.Glu371=)
NM_005633.4(SOS1):c.1940+18dup
NM_005633.4(SOS1):c.2167+16del rs79984786
NM_005633.4(SOS1):c.2167+16dup rs79984786
NM_005633.4(SOS1):c.2511-9del rs727503436
NM_005633.4(SOS1):c.3713T>C (p.Leu1238Ser)
NM_005633.4(SOS1):c.750A>C (p.Val250=)
NM_005633.4(SOS1):c.976-5dup rs771586560

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