List of variants in gene TP53 reported as likely pathogenic for not provided

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 109

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HGVS	dbSNP	gnomAD frequency
NM_000546.6(TP53):c.743G>A (p.Arg248Gln)	rs11540652	0.00002
NM_000546.6(TP53):c.374C>T (p.Thr125Met)	rs786201057	0.00001
NM_000546.6(TP53):c.472C>T (p.Arg158Cys)	rs587780068	0.00001
NM_000546.6(TP53):c.473G>A (p.Arg158His)	rs587782144	0.00001
NM_000546.6(TP53):c.541C>T (p.Arg181Cys)	rs587782596	0.00001
NM_000546.6(TP53):c.542G>A (p.Arg181His)	rs397514495	0.00001
NM_000546.6(TP53):c.713G>A (p.Cys238Tyr)	rs730882005	0.00001
NM_000546.6(TP53):c.733G>A (p.Gly245Ser)	rs28934575	0.00001
NM_000546.6(TP53):c.853G>A (p.Glu285Lys)	rs112431538	0.00001
NM_000546.6(TP53):c.1010G>T (p.Arg337Leu)	rs121912664
NM_000546.6(TP53):c.1101-1G>A	rs876658982
NM_000546.6(TP53):c.1101-2A>G	rs587781664
NM_000546.6(TP53):c.116_117del (p.Ala39fs)	rs1555526793
NM_000546.6(TP53):c.128T>A (p.Leu43Ter)	rs1555526777
NM_000546.6(TP53):c.131_143del (p.Met44fs)
NM_000546.6(TP53):c.156_163del (p.Gln52fs)
NM_000546.6(TP53):c.202G>T (p.Glu68Ter)	rs869312782
NM_000546.6(TP53):c.247del (p.Ala83fs)	rs867725248
NM_000546.6(TP53):c.273_279del (p.Trp91fs)	rs1064796124
NM_000546.6(TP53):c.298del (p.Gln100fs)	rs1567556006
NM_000546.6(TP53):c.322_339del (p.Gly108_Phe113del)	rs886039495
NM_000546.6(TP53):c.325T>A (p.Phe109Ile)
NM_000546.6(TP53):c.325T>G (p.Phe109Val)	rs1057523496
NM_000546.6(TP53):c.327_328del (p.Phe109fs)	rs1064795434
NM_000546.6(TP53):c.328_339del (p.Arg110_Phe113del)	rs587782490
NM_000546.6(TP53):c.332T>C (p.Leu111Pro)	rs1057519997
NM_000546.6(TP53):c.358A>G (p.Lys120Glu)	rs121912658
NM_000546.6(TP53):c.375+1dup	rs1555526470
NM_000546.6(TP53):c.375+2T>C	rs1555526469
NM_000546.6(TP53):c.376T>G (p.Tyr126Asp)	rs886039483
NM_000546.6(TP53):c.380C>T (p.Ser127Phe)	rs730881999
NM_000546.6(TP53):c.400_401insG (p.Phe134fs)	rs1555526286
NM_000546.6(TP53):c.401T>G (p.Phe134Cys)	rs780442292
NM_000546.6(TP53):c.404G>A (p.Cys135Tyr)	rs587781991
NM_000546.6(TP53):c.420_431del (p.Cys141_Gln144del)
NM_000546.6(TP53):c.428T>G (p.Val143Gly)	rs1555526241
NM_000546.6(TP53):c.434T>A (p.Leu145Gln)	rs587782197
NM_000546.6(TP53):c.448_460del (p.Thr150fs)	rs1064792930
NM_000546.6(TP53):c.451C>A (p.Pro151Thr)	rs28934874
NM_000546.6(TP53):c.454C>T (p.Pro152Ser)	rs767328513
NM_000546.6(TP53):c.464C>A (p.Thr155Asn)	rs786202752
NM_000546.6(TP53):c.467G>C (p.Arg156Pro)	rs371524413
NM_000546.6(TP53):c.469G>T (p.Val157Phe)	rs121912654
NM_000546.6(TP53):c.469_476del (p.Val157fs)	rs1555526137
NM_000546.6(TP53):c.473G>C (p.Arg158Pro)	rs587782144
NM_000546.6(TP53):c.473G>T (p.Arg158Leu)	rs587782144
NM_000546.6(TP53):c.476C>T (p.Ala159Val)	rs1555526131
NM_000546.6(TP53):c.482C>A (p.Ala161Asp)	rs1064795691
NM_000546.6(TP53):c.514_517dup (p.Val173fs)	rs1555526064
NM_000546.6(TP53):c.517G>T (p.Val173Leu)	rs876660754
NM_000546.6(TP53):c.526T>A (p.Cys176Ser)	rs967461896
NM_000546.6(TP53):c.535C>A (p.His179Asn)	rs587780070
NM_000546.6(TP53):c.535C>G (p.His179Asp)	rs587780070
NM_000546.6(TP53):c.536A>T (p.His179Leu)	rs1057519991
NM_000546.6(TP53):c.537T>G (p.His179Gln)	rs876660821
NM_000546.6(TP53):c.538G>A (p.Glu180Lys)	rs879253911
NM_000546.6(TP53):c.560-28_560-1del
NM_000546.6(TP53):c.569CTC[1] (p.Pro191del)	rs1555525902
NM_000546.6(TP53):c.578A>G (p.His193Arg)	rs786201838
NM_000546.6(TP53):c.578_580delinsCAGACCTAAA (p.His193fs)	rs2151027982
NM_000546.6(TP53):c.580C>T (p.Leu194Phe)	rs587780071
NM_000546.6(TP53):c.583A>T (p.Ile195Phe)	rs942158624
NM_000546.6(TP53):c.587G>T (p.Arg196Leu)	rs483352697
NM_000546.6(TP53):c.596G>T (p.Gly199Val)	rs1555525857
NM_000546.6(TP53):c.643A>G (p.Ser215Gly)	rs886039484
NM_000546.6(TP53):c.645T>G (p.Ser215Arg)	rs1057520001
NM_000546.6(TP53):c.646G>A (p.Val216Met)	rs730882025
NM_000546.6(TP53):c.646G>T (p.Val216Leu)	rs730882025
NM_000546.6(TP53):c.652G>A (p.Val218Met)	rs878854072
NM_000546.6(TP53):c.658T>A (p.Tyr220Asn)	rs530941076
NM_000546.6(TP53):c.700T>A (p.Tyr234Asn)	rs864622237
NM_000546.6(TP53):c.701A>G (p.Tyr234Cys)	rs587780073
NM_000546.6(TP53):c.707A>C (p.Tyr236Ser)	rs730882026
NM_000546.6(TP53):c.707A>G (p.Tyr236Cys)	rs730882026
NM_000546.6(TP53):c.712T>G (p.Cys238Gly)	rs1057519981
NM_000546.6(TP53):c.715A>G (p.Asn239Asp)	rs876660807
NM_000546.6(TP53):c.716A>G (p.Asn239Ser)	rs1057519999
NM_000546.6(TP53):c.731G>A (p.Gly244Asp)	rs985033810
NM_000546.6(TP53):c.734G>A (p.Gly245Asp)	rs121912656
NM_000546.6(TP53):c.734G>C (p.Gly245Ala)	rs121912656
NM_000546.6(TP53):c.736A>G (p.Met246Val)	rs483352695
NM_000546.6(TP53):c.737T>G (p.Met246Arg)	rs587780074
NM_000546.6(TP53):c.745A>G (p.Arg249Gly)	rs587782082
NM_000546.6(TP53):c.745A>T (p.Arg249Trp)	rs587782082
NM_000546.6(TP53):c.749C>T (p.Pro250Leu)	rs1064794311
NM_000546.6(TP53):c.751A>C (p.Ile251Leu)	rs730882007
NM_000546.6(TP53):c.752T>G (p.Ile251Ser)	rs730882027
NM_000546.6(TP53):c.761TCA[1] (p.Ile255del)	rs1064794309
NM_000546.6(TP53):c.764T>A (p.Ile255Asn)	rs876659675
NM_000546.6(TP53):c.794T>A (p.Leu265Gln)	rs879253942
NM_000546.6(TP53):c.797G>A (p.Gly266Glu)	rs193920774
NM_000546.6(TP53):c.799C>T (p.Arg267Trp)	rs55832599
NM_000546.6(TP53):c.809T>C (p.Phe270Ser)	rs1057519986
NM_000546.6(TP53):c.809T>G (p.Phe270Cys)	rs1057519986
NM_000546.6(TP53):c.811G>A (p.Glu271Lys)	rs1060501191
NM_000546.6(TP53):c.827C>A (p.Ala276Asp)	rs786202082
NM_000546.6(TP53):c.829T>C (p.Cys277Arg)	rs1064795369
NM_000546.6(TP53):c.830G>A (p.Cys277Tyr)	rs763098116
NM_000546.6(TP53):c.831T>A (p.Cys277Ter)	rs1057523347
NM_000546.6(TP53):c.833C>G (p.Pro278Arg)	rs876659802
NM_000546.6(TP53):c.843C>A (p.Asp281Glu)	rs1057519984
NM_000546.6(TP53):c.887A>G (p.His296Arg)	rs483352696
NM_000546.6(TP53):c.892del (p.Glu298fs)	rs2073177507
NM_000546.6(TP53):c.919+2T>A	rs1131691016
NM_000546.6(TP53):c.920-1G>C	rs587781702
NM_000546.6(TP53):c.97-2A>G	rs879254212
NM_000546.6(TP53):c.970del (p.Asp324fs)	rs1555524970
NM_000546.6(TP53):c.981T>G (p.Tyr327Ter)	rs879254077
NM_000546.6(TP53):c.993G>A (p.Gln331=)	rs11575996

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