ClinVar Miner

Variants in gene ALK

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
22 17 709 414 87 4 36 1170

Condition and significance breakdown #

Total conditions: 21
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Neuroblastoma 3 16 1 644 53 16 4 0 727
not provided 0 0 12 284 78 0 0 367
Hereditary cancer-predisposing syndrome 0 0 73 58 29 0 0 160
Neuroblastoma Susceptibility 0 0 35 43 13 0 0 91
not specified 0 0 4 39 29 0 29 86
Neuroblastoma 13 9 1 0 0 0 0 23
Lung adenocarcinoma 0 7 0 0 0 0 0 7
Non-small cell lung cancer 0 0 0 0 0 0 7 7
Neoplasm of brain 0 3 0 0 0 0 0 3
Neoplasm of the breast 0 2 0 0 0 0 0 2
Acute myeloid leukemia 0 0 1 0 0 0 0 1
Atypical teratoid/rhabdoid tumor 0 0 1 0 0 0 0 1
B lymphoblastic leukemia lymphoma with hyperdiploidy 0 0 1 0 0 0 0 1
Benign Soft Tissue Neoplasm of Uncertain Differentiation 0 0 0 0 0 0 1 1
Ganglioneuroblastoma 0 0 1 0 0 0 0 1
Large Cell/Anaplastic Medulloblastoma 0 0 1 0 0 0 0 1
Low Grade Fibromyxoid Sarcoma 0 0 1 0 0 0 0 1
Pilocytic astrocytoma 0 0 1 0 0 0 0 1
Retinoblastoma 0 0 1 0 0 0 0 1
Rhabdomyosarcoma 1 0 0 0 0 0 0 1
See cases 0 0 0 0 1 0 0 1

Submitter and significance breakdown #

Total submitters: 25
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Invitae 0 0 642 325 51 0 0 1018
Ambry Genetics 0 0 73 58 29 0 0 160
Illumina Clinical Services Laboratory,Illumina 0 0 35 43 13 0 0 91
GeneDx 0 0 6 42 37 0 0 85
ITMI 0 0 0 0 0 0 29 29
Database of Curated Mutations (DoCM) 13 16 0 0 0 0 7 28
Integrated Genetics/Laboratory Corporation of America 0 0 1 2 21 0 0 24
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 12 1 2 0 0 0 0 15
PreventionGenetics,PreventionGenetics 0 0 0 1 14 0 0 15
DNA and Cytogenetics Diagnostics Unit,Erasmus Medical Center 0 0 0 2 11 0 0 13
Fulgent Genetics,Fulgent Genetics 0 0 11 0 0 0 0 11
Diagnostic Laboratory, Department of Genetics,University Medical Center Groningen 0 0 0 2 9 0 0 11
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 1 1 7 0 0 9
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 9 0 0 0 0 9
GeneReviews 8 0 0 0 0 0 0 8
Genome Diagnostics Laboratory,VU University Medical Center Amsterdam 0 0 0 2 6 0 0 8
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine 0 0 0 0 7 0 0 7
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 3 0 4 0 0 7
OMIM 0 0 0 0 0 4 0 4
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 3 1 0 0 0 4
Mendelics 0 0 0 2 0 0 0 2
Laboratory of Genetics and Genomics,Cincinnati Children's Hospital Medical Center 0 0 0 0 2 0 0 2
Quest Diagnostics Nichols Institute San Juan Capistrano 0 0 1 0 0 0 0 1
ISCA site 8 0 0 0 0 1 0 0 1
Department of Pathology and Genetics,University of Gothenburg 1 0 0 0 0 0 0 1

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