List of variants in gene BRCA2 reported as benign by CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 43

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HGVS	dbSNP	gnomAD frequency
NM_000059.4(BRCA2):c.7806-14T>C	rs9534262	0.53977
NM_000059.4(BRCA2):c.10234A>G (p.Ile3412Val)	rs1801426	0.03864
NM_000059.4(BRCA2):c.7397= (p.Val2466=)	rs169547	0.02098
NM_000059.4(BRCA2):c.8487+19A>G	rs11571743	0.01055
NM_000059.4(BRCA2):c.7319A>G (p.His2440Arg)	rs4986860	0.00984
NM_000059.4(BRCA2):c.7469T>C (p.Ile2490Thr)	rs11571707	0.00868
NM_000059.4(BRCA2):c.8851G>A (p.Ala2951Thr)	rs11571769	0.00809
NM_000059.4(BRCA2):c.3264T>C (p.Pro1088=)	rs36060526	0.00793
NM_000059.4(BRCA2):c.7017G>C (p.Lys2339Asn)	rs45574331	0.00792
NM_000059.4(BRCA2):c.9730G>A (p.Val3244Ile)	rs11571831	0.00792
NM_000059.4(BRCA2):c.5418A>G (p.Glu1806=)	rs34351119	0.00791
NM_000059.4(BRCA2):c.517-19C>T	rs11571623	0.00693
NM_000059.3(BRCA2):c.5704G>A (p.Asp1902Asn)	rs4987048	0.00655
NM_000059.4(BRCA2):c.4258G>T (p.Asp1420Tyr)	rs28897727	0.00609
NM_000059.4(BRCA2):c.9257-16T>C	rs11571818	0.00597
NM_000059.4(BRCA2):c.-11C>T	rs76874770	0.00539
NM_000059.4(BRCA2):c.5199C>T (p.Ser1733=)	rs28897734	0.00488
NM_000059.4(BRCA2):c.6347A>G (p.His2116Arg)	rs55953736	0.00396
NM_000059.4(BRCA2):c.2960A>T (p.Asn987Ile)	rs2227944	0.00356
NM_000059.4(BRCA2):c.2786T>C (p.Leu929Ser)	rs2227943	0.00355
NM_000059.4(BRCA2):c.6412G>T (p.Val2138Phe)	rs11571659	0.00346
NM_000059.4(BRCA2):c.1275A>G (p.Glu425=)	rs34355306	0.00335
NM_000059.4(BRCA2):c.3869G>A (p.Cys1290Tyr)	rs41293485	0.00307
NM_000059.4(BRCA2):c.4068G>A (p.Leu1356=)	rs28897724	0.00295
NM_000059.4(BRCA2):c.68-7T>A	rs81002830	0.00277
NM_000059.4(BRCA2):c.6100C>T (p.Arg2034Cys)	rs1799954	0.00268
NM_000059.4(BRCA2):c.6323G>A (p.Arg2108His)	rs35029074	0.00260
NM_000059.4(BRCA2):c.8182G>A (p.Val2728Ile)	rs28897749	0.00239
NM_000059.4(BRCA2):c.8503T>C (p.Ser2835Pro)	rs11571746	0.00202
NM_000059.4(BRCA2):c.1792A>G (p.Thr598Ala)	rs28897710	0.00182
NM_000059.4(BRCA2):c.8149G>T (p.Ala2717Ser)	rs28897747	0.00127
NM_000059.4(BRCA2):c.6821G>T (p.Gly2274Val)	rs55712212	0.00126
NM_000059.4(BRCA2):c.9235G>A (p.Val3079Ile)	rs55933907	0.00106
NM_000059.4(BRCA2):c.1938C>T (p.Ser646=)	rs28897711	0.00096
NM_000059.4(BRCA2):c.1964C>G (p.Pro655Arg)	rs28897712	0.00054
NM_000059.4(BRCA2):c.9649-19G>A	rs11571830	0.00047
NM_000059.4(BRCA2):c.6853A>G (p.Ile2285Val)	rs56272235	0.00026
NM_000059.4(BRCA2):c.1786G>C (p.Asp596His)	rs56328701	0.00025
NM_000059.4(BRCA2):c.6322C>T (p.Arg2108Cys)	rs55794205	0.00019
NM_000059.4(BRCA2):c.3420T>C (p.Ser1140=)	rs118093942	0.00008
NM_000059.4(BRCA2):c.1538A>G (p.Lys513Arg)	rs28897709	0.00002
NM_000059.4(BRCA2):c.1909+22dup	rs276174816
NM_000059.4(BRCA2):c.4090A>C (p.Ile1364Leu)	rs56248502

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