List of variants in gene CUBN reported as benign by Breakthrough Genomics, Breakthrough Genomics

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 95

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HGVS	dbSNP	gnomAD frequency
NM_001081.4(CUBN):c.8150C>G (p.Ser2717Trp)	rs2796835	0.99996
NM_001081.4(CUBN):c.6485G>A (p.Cys2162Tyr)	rs1276712	0.99748
NM_001081.4(CUBN):c.4169-47T>C	rs925523	0.93990
NM_001081.4(CUBN):c.123-16C>G	rs2281648	0.87734
NM_001081.4(CUBN):c.2791+9C>T	rs10795440	0.86232
NM_001081.4(CUBN):c.2791+130G>A	rs4747297	0.86168
NM_001081.4(CUBN):c.4525+94T>G	rs2291523	0.85958
NM_001081.4(CUBN):c.1765+52G>T	rs1033765	0.84784
NM_001081.4(CUBN):c.6463-22A>C	rs1276713	0.83614
NM_001081.4(CUBN):c.7912+25T>C	rs780807	0.76246
NM_001081.4(CUBN):c.4351-106T>C	rs3012494	0.75876
NM_001081.4(CUBN):c.10180+30A>G	rs703062	0.74847
NM_001081.4(CUBN):c.4695+79G>A	rs3012484	0.73127
NM_001081.4(CUBN):c.4563T>A (p.Ile1521=)	rs1801229	0.73095
NM_001081.4(CUBN):c.4675C>T (p.Pro1559Ser)	rs1801231	0.73090
NM_001081.4(CUBN):c.758T>C (p.Phe253Ser)	rs1801222	0.72697
NM_001081.4(CUBN):c.9843A>G (p.Thr3281=)	rs703064	0.70381
NM_001081.4(CUBN):c.7705+60T>G	rs780804	0.68058
NM_001081.4(CUBN):c.10362+91T>C	rs703060	0.60182
NM_001081.4(CUBN):c.1165C>A (p.Pro389Thr)	rs1801224	0.57972
NM_001081.4(CUBN):c.5856A>G (p.Ser1952=)	rs1801234	0.50538
NM_001081.4(CUBN):c.9454+30G>T	rs703075	0.47504
NM_001081.4(CUBN):c.4969+228G>T	rs2271469	0.46566
NM_001081.4(CUBN):c.7705+106C>T	rs780805	0.42774
NM_001081.4(CUBN):c.2487G>A (p.Ser829=)	rs1801225	0.34517
NM_001081.4(CUBN):c.*601A>G	rs780635	0.34264
NM_001081.4(CUBN):c.10528+171G>A	rs7088468	0.23478
NM_001081.4(CUBN):c.5210-61A>G	rs2271466	0.23222
NM_001081.4(CUBN):c.1015+63C>T	rs12242395	0.21213
NM_001081.4(CUBN):c.939C>T (p.Asn313=)	rs1801223	0.21191
NM_001081.4(CUBN):c.4350+52G>A	rs2291521	0.20233
NM_001081.4(CUBN):c.5343-8C>A	rs2271463	0.19341
NM_001081.4(CUBN):c.6124+8C>T	rs2271461	0.17660
NM_001081.4(CUBN):c.9030T>C (p.Ala3010=)	rs1801241	0.16648
NM_001081.4(CUBN):c.4970-22A>C	rs74668791	0.13498
NM_001081.4(CUBN):c.5803A>G (p.Ser1935Gly)	rs41289305	0.13356
NM_001081.4(CUBN):c.9005A>G (p.Glu3002Gly)	rs1801240	0.12902
NM_001081.4(CUBN):c.6459G>C (p.Leu2153Phe)	rs62619939	0.12828
NM_001081.4(CUBN):c.5210-120A>T	rs2271467	0.12375
NM_001081.4(CUBN):c.*134G>A	rs780636	0.12332
NM_001081.4(CUBN):c.5926+25C>A	rs2356589	0.12317
NM_001081.4(CUBN):c.4695+42C>T	rs41289309	0.10178
NM_001081.4(CUBN):c.3522C>T (p.Gly1174=)	rs1873469	0.09173
NM_001081.4(CUBN):c.8599-178T>C	rs7087545	0.08314
NM_001081.4(CUBN):c.7662A>G (p.Pro2554=)	rs3740165	0.08230
NM_001081.4(CUBN):c.8950A>G (p.Ile2984Val)	rs1801239	0.07706
NM_001081.4(CUBN):c.2188C>T (p.His730Tyr)	rs7905349	0.07515
NM_001081.4(CUBN):c.5518G>A (p.Gly1840Ser)	rs2271462	0.07196
NM_001081.4(CUBN):c.5134C>T (p.Leu1712=)	rs2271468	0.07161
NM_001081.4(CUBN):c.489+42C>T	rs41289315	0.07042
NM_001081.4(CUBN):c.10295C>G (p.Thr3432Ser)	rs7898873	0.06787
NM_001081.4(CUBN):c.1112-227C>T	rs60534442	0.06418
NM_001081.4(CUBN):c.3008+75T>C	rs12251381	0.06390
NM_001081.4(CUBN):c.6124+62A>T	rs61687032	0.06290
NM_001081.4(CUBN):c.4169-76C>T	rs12359150	0.05904
NM_001081.4(CUBN):c.4970-186A>G	rs61841459	0.05814
NM_001081.4(CUBN):c.4855+179C>T	rs74116779	0.05692
NM_001081.4(CUBN):c.5304C>T (p.Ile1768=)	rs61841454	0.05662
NM_001081.4(CUBN):c.7913-11A>G	rs7088988	0.05036
NM_001081.4(CUBN):c.2792-18T>A	rs10904871	0.05019
NM_001081.4(CUBN):c.8905+54A>G	rs73592350	0.03516
NM_001081.4(CUBN):c.3417A>G (p.Leu1139=)	rs1801228	0.03502
NM_001081.4(CUBN):c.109A>C (p.Ile37Leu)	rs76788243	0.03499
NM_001081.4(CUBN):c.7351+99C>T	rs75179417	0.03222
NM_001081.4(CUBN):c.8635C>A (p.Leu2879Ile)	rs1801238	0.02483
NM_001081.4(CUBN):c.7724C>G (p.Pro2575Arg)	rs3740168	0.02405
NM_001081.4(CUBN):c.2791+14C>T	rs111781659	0.02202
NM_001081.4(CUBN):c.196G>A (p.Gly66Arg)	rs12259370	0.02097
NM_001081.4(CUBN):c.2791+6A>C	rs78549445	0.01999
NM_001081.4(CUBN):c.10265C>T (p.Thr3422Ile)	rs1801230	0.01655
NM_001081.4(CUBN):c.*305T>G	rs143326344	0.01612
NM_001081.4(CUBN):c.5924C>T (p.Pro1975Leu)	rs41289303	0.01542
NM_001081.4(CUBN):c.*151G>A	rs76742384	0.01235
NM_001081.4(CUBN):c.6561G>A (p.Ser2187=)	rs11254278	0.01067
NM_001081.4(CUBN):c.8741C>T (p.Ala2914Val)	rs45551835	0.00977
NM_001081.4(CUBN):c.4872C>T (p.Ile1624=)	rs114958584	0.00910
NM_001081.4(CUBN):c.6788T>G (p.Phe2263Cys)	rs2271460	0.00803
NM_001081.4(CUBN):c.10039G>A (p.Gly3347Arg)	rs146027947	0.00782
NM_001081.4(CUBN):c.5011A>C (p.Arg1671=)	rs144472791	0.00255
NM_001081.4(CUBN):c.1417+20T>C	rs181536212	0.00151
NM_001081.4(CUBN):c.348+17C>T	rs200466568	0.00114
NM_001081.4(CUBN):c.9206C>T (p.Thr3069Ile)	rs117400821	0.00114
NM_001081.4(CUBN):c.10656C>A (p.Asn3552Lys)	rs1801232
NM_001081.4(CUBN):c.1911C>T (p.Leu637=)	rs41289311
NM_001081.4(CUBN):c.4018-166T>C	rs35013380
NM_001081.4(CUBN):c.4169-45T>G	rs925522
NM_001081.4(CUBN):c.4696-80C>T	rs115376431
NM_001081.4(CUBN):c.489+35A>C	rs2273737
NM_001081.4(CUBN):c.5305G>A (p.Val1769Ile)	rs74116778
NM_001081.4(CUBN):c.5549-101A>C	rs74116774
NM_001081.4(CUBN):c.5733+37G>A	rs3817218
NM_001081.4(CUBN):c.5911C>A (p.Pro1971Thr)	rs2356590
NM_001081.4(CUBN):c.593+169T>G	rs7070148
NM_001081.4(CUBN):c.7346T>C (p.Met2449Thr)	rs41301097
NM_001081.4(CUBN):c.9454+68G>A	rs703074

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