ClinVar Miner

Variants in gene CYP2C19

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign drug response other total
0 0 0 1 4 407 5 411

Condition and significance breakdown #

Total conditions: 19
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Condition likely benign benign drug response other total
Citalopram response 0 0 405 0 405
Escitalopram response 0 0 405 0 405
Sertraline response 0 0 405 0 405
Voriconazole response 0 0 405 0 405
Clopidogrel response 0 0 29 0 29
CYP2C19: no function 0 0 10 0 10
CYP2C19: uncertain function 0 0 9 0 9
not provided 0 3 0 5 8
CYP2C19: decreased function 0 0 6 0 6
CYP2C19: normal function 0 0 4 0 4
Mephenytoin, poor metabolism of 0 0 4 0 4
Proguanil, poor metabolism of 0 0 2 0 2
clopidogrel response - Efficacy, Toxicity/ADR 0 0 2 0 2
Abnormality of esophagus morphology 0 1 0 0 1
amitriptyline response - Efficacy 0 0 1 0 1
citalopram response - Efficacy 0 0 1 0 1
clomipramine response - Efficacy 0 0 1 0 1
clopidogrel response - Efficacy 0 0 1 0 1
not specified 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 7
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Submitter likely benign benign drug response other total
Clinical Pharmacogenetics Implementation Consortium 0 0 406 0 406
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 0 5 5
OMIM 0 0 4 0 4
PharmGKB 0 0 3 0 3
Laboratory of Genetics and Genomics,Cincinnati Children's Hospital Medical Center 0 3 0 0 3
GeneDx 1 0 0 0 1
Clinical Genetics, Erasmus University Medical Center 0 1 0 0 1

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