ClinVar Miner

Variants in gene FANCM

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
63 20 650 190 39 2 933

Condition and significance breakdown #

Total conditions: 12
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Fanconi anemia 59 10 610 153 31 0 863
not provided 3 6 24 42 2 1 77
not specified 0 0 3 10 18 0 31
Spermatogenic failure 28 6 0 25 0 0 0 30
Hereditary breast and ovarian cancer syndrome 0 2 21 1 0 0 24
Spermatogenic failure 28; Premature ovarian failure 15 0 0 10 0 0 0 10
Fanconi anemia, complementation group A 0 1 5 2 0 0 8
Fanconi anemia, complementation group M 0 0 2 0 0 1 3
Familial cancer of breast 2 0 0 0 0 0 2
Premature ovarian failure 15 1 0 0 0 1 0 2
Malignant germ cell tumor of ovary 1 0 0 0 0 0 1
Retinoblastoma 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 23
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 59 10 606 176 31 0 882
Baylor Genetics 1 0 25 0 0 0 26
Cancer Genomics Group,Japanese Foundation For Cancer Research 0 2 21 1 0 0 24
PreventionGenetics, PreventionGenetics 0 0 0 3 14 0 17
CeGaT Praxis fuer Humangenetik Tuebingen 2 3 9 3 0 0 17
Fulgent Genetics,Fulgent Genetics 0 0 10 0 0 0 10
Genetic Services Laboratory, University of Chicago 0 0 2 6 1 0 9
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 0 0 8 0 8
Mendelics 0 1 5 2 0 0 8
OMIM 5 0 2 0 0 0 7
GeneDx 1 2 4 0 0 0 7
Department of Pathology and Laboratory Medicine,Sinai Health System 0 0 4 0 2 0 6
Gharavi Laboratory,Columbia University 0 0 6 0 0 0 6
Illumina Clinical Services Laboratory,Illumina 0 0 4 0 0 0 4
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 3 0 0 0 3
Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics,Cincinnati Children's Hospital Medical Center 0 0 0 0 2 0 2
GenomeConnect, ClinGen 0 0 0 0 0 2 2
St. Jude Clinical Genomics Lab, St. Jude Children's Research Hospital 1 1 0 0 0 0 2
Division of Medical Genetics, University of Washington 2 0 0 0 0 0 2
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics,Children's Hospital of Philadelphia 0 0 0 0 1 0 1
Developmental Genetics Unit,King Faisal Specialist Hospital & Research Centre 0 0 0 1 0 0 1
Center for Individualized Medicine,Mayo Clinic 0 1 0 0 0 0 1
Institute of Human Genetics, University of Leipzig Medical Center 0 0 0 0 1 0 1

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