ClinVar Miner

Variants in gene FUS

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Minimum submission review status: Collection method:
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Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
36 13 256 206 80 519

Condition and significance breakdown #

Total conditions: 13
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Condition pathogenic likely pathogenic uncertain significance likely benign benign total
Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 18 1 100 100 29 246
Amyotrophic lateral sclerosis type 6 15 6 89 18 37 163
not provided 11 5 39 54 36 134
Inborn genetic diseases 1 0 36 60 2 99
FUS-related condition 2 0 17 33 5 57
not specified 0 0 3 7 10 20
Amyotrophic Lateral Sclerosis, Dominant 0 0 5 3 0 8
Tremor, hereditary essential, 4 3 0 2 0 3 8
Juvenile amyotrophic lateral sclerosis 2 0 0 0 0 2
Amyotrophic lateral sclerosis 6, autosomal recessive 1 0 0 0 0 1
Distal spinal muscular atrophy 0 0 1 0 0 1
Dystonic disorder; Myoclonus 0 0 1 0 0 1
Frontotemporal dementia 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 33
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
Invitae 18 1 100 103 29 251
Illumina Laboratory Services, Illumina 1 0 88 21 35 145
Ambry Genetics 1 0 36 60 2 99
GeneDx 5 3 11 32 29 80
PreventionGenetics, part of Exact Sciences 2 0 17 37 9 65
CeGaT Center for Human Genetics Tuebingen 5 1 17 13 6 42
Athena Diagnostics Inc 3 0 7 3 9 22
OMIM 12 0 0 0 0 12
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 9 3 12
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 1 0 0 5 5 11
Genome Diagnostics Laboratory, University Medical Center Utrecht 1 0 0 2 4 7
Suna and Inan Kirac Foundation Neurodegeneration Research Laboratory, Koc University 4 3 0 0 0 7
Revvity Omics, Revvity 1 0 4 0 0 5
Mendelics 0 1 2 0 2 5
Clinical Genetics, Academic Medical Center 0 0 0 0 4 4
Fulgent Genetics, Fulgent Genetics 0 0 1 2 1 4
Neuberg Supratech Reference Laboratories Pvt Ltd, Neuberg Centre for Genomic Medicine 2 0 2 0 0 4
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 1 2 3
AiLife Diagnostics, AiLife Diagnostics 0 1 2 0 0 3
Genome-Nilou Lab 0 0 0 0 3 3
Institute of Human Genetics, Cologne University 1 0 1 0 0 2
MGZ Medical Genetics Center 0 0 2 0 0 2
Baylor Genetics 0 0 1 0 0 1
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 0 1 0 1
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 0 0 1 0 0 1
Mayo Clinic Laboratories, Mayo Clinic 1 0 0 0 0 1
Institute Of Human Genetics Munich, Klinikum Rechts Der Isar, Tu München 1 0 0 0 0 1
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 1 0 0 1
Neurology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University 1 0 0 0 0 1
3billion 0 1 0 0 0 1
Molecular Genetics, Royal Melbourne Hospital 0 0 1 0 0 1
Guerreiro-Bras Laboratory, Van Andel Institute 0 1 0 0 0 1
Department of Research, Sir Ganga Ram Hospital 0 1 0 0 0 1

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