List of variants in gene MLH1 reported as benign for Lynch syndrome

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 55

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HGVS	dbSNP	gnomAD frequency
NM_000249.4(MLH1):c.1668-19A>G	rs9876116	0.41821
NM_000249.4(MLH1):c.790+955C>A	rs1558528	0.41529
NM_000249.4(MLH1):c.453+79A>G	rs4234259	0.41512
NM_000249.4(MLH1):c.1990-121C>T	rs2241031	0.41163
NM_000249.4(MLH1):c.207+571C>T	rs9852378	0.39684
NM_000249.4(MLH1):c.1038+1005G>T	rs3774338	0.39669
NM_000249.4(MLH1):c.1668-885T>C	rs748766	0.37254
NM_000249.4(MLH1):c.1039-78A>G	rs11129748	0.36570
NM_000249.4(MLH1):c.1558+2204A>C	rs3774335	0.36225
NM_000249.4(MLH1):c.1559-3171A>G	rs4678925	0.35667
NM_000249.4(MLH1):c.791-1406C>T	rs4647269	0.35636
NM_000249.4(MLH1):c.306+416A>C	rs4647222	0.35615
NM_000249.4(MLH1):c.655A>G (p.Ile219Val)	rs1799977	0.23048
NM_000249.3(MLH1):c.-93G>A	rs1800734	0.22121
NM_000249.4(MLH1):c.307-1403A>T	rs1540354	0.14330
NM_000249.4(MLH1):c.1558+14G>A	rs41562513	0.05554
NM_000249.4(MLH1):c.1558+4245A>G	rs3774332	0.05535
NM_000249.4(MLH1):c.1410-54C>T	rs7633154	0.04850
NM_000249.4(MLH1):c.454-51T>C	rs4647255	0.03218
NM_000249.4(MLH1):c.1668-254C>T	rs41552415	0.03054
NM_000249.4(MLH1):c.2152C>T (p.His718Tyr)	rs2020873	0.02345
NM_000249.4(MLH1):c.885-81G>C	rs104894999	0.02021
NM_000249.4(MLH1):c.381-41A>G	rs4647245	0.01794
NM_000249.4(MLH1):c.1039-8T>A	rs193922367	0.01153
NM_000249.4(MLH1):c.588+11G>C	rs4647258	0.00993
NM_000249.4(MLH1):c.1732-19T>A	rs77120160	0.00923
NM_000249.4(MLH1):c.1959G>T (p.Leu653=)	rs1800146	0.00913
NM_000249.4(MLH1):c.637G>A (p.Val213Met)	rs2308317	0.00818
NM_000249.4(MLH1):c.589-15C>T	rs55658850	0.00582
NM_000249.4(MLH1):c.545+20A>T	rs121909453	0.00424
NM_000249.4(MLH1):c.453+25A>G	rs4647246	0.00414
NM_000249.4(MLH1):c.307-29C>A	rs139620056	0.00398
NM_000249.4(MLH1):c.790+10A>G	rs182733777	0.00188
NM_000249.4(MLH1):c.2146G>A (p.Val716Met)	rs35831931	0.00143
NM_000249.4(MLH1):c.1217G>A (p.Ser406Asn)	rs41294980	0.00087
NM_000249.4(MLH1):c.1151T>A (p.Val384Asp)	rs63750447	0.00077
NM_000249.4(MLH1):c.977T>C (p.Val326Ala)	rs63751049	0.00037
NM_000249.4(MLH1):c.1321G>A (p.Ala441Thr)	rs63750365	0.00034
NM_000249.4(MLH1):c.2066A>G (p.Gln689Arg)	rs63750702	0.00022
NM_000249.4(MLH1):c.394G>C (p.Asp132His)	rs28930073	0.00019
NM_000249.4(MLH1):c.1040C>A (p.Thr347Asn)	rs201541505	0.00017
NM_000249.4(MLH1):c.65G>C (p.Gly22Ala)	rs41295280	0.00016
NM_000249.4(MLH1):c.803A>G (p.Glu268Gly)	rs63750650	0.00014
NM_000249.4(MLH1):c.1733A>G (p.Glu578Gly)	rs63751612	0.00006
NM_000249.4(MLH1):c.1128T>C (p.Asp376=)	rs267607824	0.00005
NM_000249.4(MLH1):c.1039-33_1039-29del	rs148615368	0.00003
NM_000249.4(MLH1):c.303T>G (p.Gly101=)	rs4647220	0.00002
NM_000249.4(MLH1):c.1652A>G (p.Asn551Ser)	rs63750271	0.00001
NM_000249.4(MLH1):c.*32CTT[1]	rs193922366
NM_000249.4(MLH1):c.1038+86T>C	rs2286939
NM_000249.4(MLH1):c.1799A>G (p.Glu600Gly)	rs267607861
NM_000249.4(MLH1):c.1852_1853delinsGC (p.Lys618Ala)	rs35502531
NM_000249.4(MLH1):c.1853A>C (p.Lys618Thr)	rs63750449
NM_000249.4(MLH1):c.453+554C>T	rs267607748
NM_000249.4(MLH1):c.655A>C (p.Ile219Leu)	rs1799977

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