List of variants in gene MLH1 reported as likely benign by PreventionGenetics, part of Exact Sciences

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 62

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HGVS	dbSNP	gnomAD frequency
NM_000249.4(MLH1):c.2146G>A (p.Val716Met)	rs35831931	0.00143
NM_000249.4(MLH1):c.1217G>A (p.Ser406Asn)	rs41294980	0.00087
NM_000249.4(MLH1):c.375A>G (p.Ala125=)	rs1800144	0.00062
NM_000249.4(MLH1):c.977T>C (p.Val326Ala)	rs63751049	0.00037
NM_000249.4(MLH1):c.1321G>A (p.Ala441Thr)	rs63750365	0.00034
NM_000249.4(MLH1):c.1897-17C>G	rs2308316	0.00029
NM_000249.4(MLH1):c.2066A>G (p.Gln689Arg)	rs63750702	0.00022
NM_000249.4(MLH1):c.1166G>A (p.Arg389Gln)	rs63750361	0.00020
NM_000249.4(MLH1):c.394G>C (p.Asp132His)	rs28930073	0.00019
NM_000249.4(MLH1):c.2101C>A (p.Gln701Lys)	rs63750114	0.00016
NM_000249.4(MLH1):c.65G>C (p.Gly22Ala)	rs41295280	0.00016
NM_000249.4(MLH1):c.1820T>A (p.Leu607His)	rs41295284	0.00015
NM_000249.4(MLH1):c.1050A>G (p.Pro350=)	rs137937003	0.00012
NM_000249.4(MLH1):c.843A>C (p.Ala281=)	rs146796765	0.00012
NM_000249.4(MLH1):c.1964T>C (p.Ile655Thr)	rs63751225	0.00010
NM_000249.4(MLH1):c.1808C>G (p.Pro603Arg)	rs63750876	0.00009
NM_000249.4(MLH1):c.1742C>T (p.Pro581Leu)	rs63751684	0.00008
NM_000249.4(MLH1):c.42A>C (p.Thr14=)	rs369737664	0.00007
NM_000249.4(MLH1):c.649C>T (p.Arg217Cys)	rs4986984	0.00007
NM_000249.4(MLH1):c.552A>T (p.Ser184=)	rs35225190	0.00006
NM_000249.4(MLH1):c.1020C>G (p.Ser340=)	rs374770981	0.00005
NM_000249.4(MLH1):c.1392T>C (p.Pro464=)	rs63750201	0.00005
NM_000249.4(MLH1):c.438A>G (p.Gln146=)	rs377279035	0.00005
NM_000249.3(MLH1):c.-100T>C	rs4647204	0.00004
NM_000249.4(MLH1):c.1284T>C (p.Asp428=)	rs772555970	0.00004
NM_000249.4(MLH1):c.1590C>T (p.Phe530=)	rs752241564	0.00004
NM_000249.4(MLH1):c.2252A>G (p.Lys751Arg)	rs140195825	0.00004
NM_000249.4(MLH1):c.579A>G (p.Ser193=)	rs587781038	0.00004
NM_000249.4(MLH1):c.1743G>A (p.Pro581=)	rs567838745	0.00003
NM_000249.4(MLH1):c.974G>A (p.Arg325Gln)	rs63750268	0.00002
NM_000249.4(MLH1):c.108T>C (p.Ile36=)	rs730881747	0.00001
NM_000249.4(MLH1):c.1551A>G (p.Gly517=)	rs373322226	0.00001
NM_000249.4(MLH1):c.1896+7C>T	rs863224339	0.00001
NM_000249.4(MLH1):c.1902G>A (p.Gly634=)	rs376866470	0.00001
NM_000249.4(MLH1):c.1989+14C>T	rs763711727	0.00001
NM_000249.4(MLH1):c.1990-6G>A	rs117221851	0.00001
NM_000249.4(MLH1):c.2070C>T (p.Tyr690=)	rs550890395	0.00001
NM_000249.4(MLH1):c.2172G>A (p.Leu724=)	rs780045031	0.00001
NM_000249.4(MLH1):c.222T>C (p.Asp74=)	rs755073786	0.00001
NM_000249.4(MLH1):c.24T>A (p.Ile8=)	rs748406142	0.00001
NM_000249.4(MLH1):c.261C>T (p.Ser87=)	rs63750923	0.00001
NM_000249.4(MLH1):c.351G>A (p.Thr117=)	rs61751643	0.00001
NM_000249.4(MLH1):c.51C>T (p.Asn17=)	rs761498953	0.00001
NM_000249.4(MLH1):c.884+10C>T	rs864622424	0.00001
NM_000249.4(MLH1):c.885-5G>T	rs267607802	0.00001
NM_000249.3(MLH1):c.-117G>T	rs565891017
NM_000249.4(MLH1):c.1020C>T (p.Ser340=)	rs374770981
NM_000249.4(MLH1):c.1039-8_1039-7insTA	rs535965616
NM_000249.4(MLH1):c.1359G>A (p.Lys453=)	rs756099600
NM_000249.4(MLH1):c.1410-4G>T	rs1057520517
NM_000249.4(MLH1):c.1476A>C (p.Ala492=)	rs864622619
NM_000249.4(MLH1):c.1853A>G (p.Lys618Arg)	rs63750449
NM_000249.4(MLH1):c.2091C>T (p.Leu697=)	rs536488280
NM_000249.4(MLH1):c.2121C>T (p.Ser707=)	rs886038273
NM_000249.4(MLH1):c.2184T>A (p.Ile728=)	rs1057524100
NM_000249.4(MLH1):c.516A>G (p.Glu172=)	rs748128054
NM_000249.4(MLH1):c.546-16del	rs1559529693
NM_000249.4(MLH1):c.552A>G (p.Ser184=)
NM_000249.4(MLH1):c.589-9G>T	rs566497442
NM_000249.4(MLH1):c.603A>G (p.Val201=)	rs2125808325
NM_000249.4(MLH1):c.633A>T (p.Ser211=)	rs2125808875
NM_000249.4(MLH1):c.884+448T>C

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