ClinVar Miner

List of variants in gene MLH1 reported as likely benign by GeneDx

Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:
Total variants: 258
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HGVS dbSNP gnomAD frequency
NM_000249.4(MLH1):c.1039-31del rs756911937 0.04867
NM_000249.4(MLH1):c.453+192C>T rs4647248 0.01408
NM_000249.4(MLH1):c.208-138A>C rs4647219 0.01367
NM_000249.4(MLH1):c.1038+245T>C rs56232171 0.01161
NM_000249.4(MLH1):c.1039-336T>C rs113939899 0.01037
NM_000249.4(MLH1):c.1039-26T>A rs1360955428 0.00920
NM_000249.4(MLH1):c.1038+246A>T rs55824225 0.00808
NM_000249.4(MLH1):c.1897-145C>G rs145050866 0.00694
NM_000249.4(MLH1):c.1732-152G>C rs116313999 0.00671
NM_000249.4(MLH1):c.1897-202T>G rs113994452 0.00557
NM_000249.4(MLH1):c.380+164A>G rs4647235 0.00553
NM_000249.4(MLH1):c.885-460G>A rs150319478 0.00427
NM_000249.4(MLH1):c.453+25A>G rs4647246 0.00414
NM_000249.4(MLH1):c.307-29C>A rs139620056 0.00398
NM_000249.4(MLH1):c.1038+106G>C rs55920215 0.00378
NM_000249.4(MLH1):c.677+168C>A rs56008923 0.00357
NM_000249.4(MLH1):c.307-1563C>T rs148965625 0.00349
NM_000249.4(MLH1):c.1732-2430T>C rs138557254 0.00345
NM_000249.4(MLH1):c.1410-1364A>G rs192737280 0.00302
NM_000249.4(MLH1):c.-7C>T rs104894994 0.00115
NM_000249.4(MLH1):c.-28A>G rs56198082 0.00110
NM_000249.4(MLH1):c.1039-7A>T rs1200394799 0.00061
NM_000249.4(MLH1):c.977T>C (p.Val326Ala) rs63751049 0.00037
NM_000249.4(MLH1):c.1321G>A (p.Ala441Thr) rs63750365 0.00034
NM_000249.4(MLH1):c.1897-17C>G rs2308316 0.00029
NM_000249.4(MLH1):c.1166G>A (p.Arg389Gln) rs63750361 0.00020
NM_000249.4(MLH1):c.394G>C (p.Asp132His) rs28930073 0.00019
NM_000249.4(MLH1):c.2101C>A (p.Gln701Lys) rs63750114 0.00016
NM_000249.4(MLH1):c.65G>C (p.Gly22Ala) rs41295280 0.00016
NM_000249.4(MLH1):c.1820T>A (p.Leu607His) rs41295284 0.00015
NM_000249.4(MLH1):c.2001C>T (p.Asp667=) rs63750014 0.00014
NM_000249.4(MLH1):c.803A>G (p.Glu268Gly) rs63750650 0.00014
NM_000249.4(MLH1):c.626A>G (p.Asn209Ser) rs150478207 0.00011
NM_000249.4(MLH1):c.1964T>C (p.Ile655Thr) rs63751225 0.00010
NM_000249.4(MLH1):c.1808C>G (p.Pro603Arg) rs63750876 0.00009
NM_000249.4(MLH1):c.2103+14G>A rs769533221 0.00009
NM_000249.4(MLH1):c.1742C>T (p.Pro581Leu) rs63751684 0.00008
NM_000249.4(MLH1):c.*4T>C rs750794400 0.00007
NM_000249.4(MLH1):c.117-10G>A rs576724240 0.00007
NM_000249.4(MLH1):c.1379A>C (p.Glu460Ala) rs202038499 0.00007
NM_000249.4(MLH1):c.1908G>A (p.Leu636=) rs1800145 0.00007
NM_000249.4(MLH1):c.277A>G (p.Ser93Gly) rs41295282 0.00007
NM_000249.4(MLH1):c.589-8T>C rs1017112753 0.00007
NM_000249.4(MLH1):c.649C>T (p.Arg217Cys) rs4986984 0.00007
NM_000249.4(MLH1):c.1013A>G (p.Asn338Ser) rs63751467 0.00006
NM_000249.4(MLH1):c.1360G>C (p.Gly454Arg) rs63750527 0.00006
NM_000249.4(MLH1):c.1733A>G (p.Glu578Gly) rs63751612 0.00006
NM_000249.4(MLH1):c.552A>T (p.Ser184=) rs35225190 0.00006
NM_000249.4(MLH1):c.1153C>T (p.Arg385Cys) rs63750760 0.00005
NM_000249.4(MLH1):c.438A>G (p.Gln146=) rs377279035 0.00005
NM_000249.4(MLH1):c.1779A>G (p.Pro593=) rs786201766 0.00004
NM_000249.4(MLH1):c.2252A>G (p.Lys751Arg) rs140195825 0.00004
NM_000249.4(MLH1):c.380+17T>A rs953236969 0.00004
NM_000249.4(MLH1):c.808A>G (p.Thr270Ala) rs371302926 0.00004
NM_000249.4(MLH1):c.117-16C>G rs766749140 0.00003
NM_000249.4(MLH1):c.1743G>A (p.Pro581=) rs567838745 0.00003
NM_000249.4(MLH1):c.191A>G (p.Asn64Ser) rs63750952 0.00003
NM_000249.4(MLH1):c.1990-93C>T rs757567978 0.00003
NM_000249.4(MLH1):c.453+20G>T rs759417195 0.00003
NM_000249.4(MLH1):c.884+15A>G rs372817491 0.00003
NM_000249.4(MLH1):c.927C>A (p.Pro309=) rs63749896 0.00003
NM_000249.4(MLH1):c.1515T>C (p.Ser505=) rs774699212 0.00002
NM_000249.4(MLH1):c.1667+17T>G rs774137820 0.00002
NM_000249.4(MLH1):c.1872C>T (p.Asp624=) rs145535636 0.00002
NM_000249.4(MLH1):c.45G>C (p.Val15=) rs768409958 0.00002
NM_000249.4(MLH1):c.595G>C (p.Glu199Gln) rs63749887 0.00002
NM_000249.4(MLH1):c.974G>A (p.Arg325Gln) rs63750268 0.00002
NM_000249.3(MLH1):c.-31dup rs747856324 0.00001
NM_000249.4(MLH1):c.*3A>G rs587778880 0.00001
NM_000249.4(MLH1):c.1038+9G>A rs267607817 0.00001
NM_000249.4(MLH1):c.108T>C (p.Ile36=) rs730881747 0.00001
NM_000249.4(MLH1):c.116+4C>T rs1057523910 0.00001
NM_000249.4(MLH1):c.116+8G>A rs904872305 0.00001
NM_000249.4(MLH1):c.1164C>T (p.Ser388=) rs1060504014 0.00001
NM_000249.4(MLH1):c.1167G>A (p.Arg389=) rs772805767 0.00001
NM_000249.4(MLH1):c.1230C>T (p.Ala410=) rs764377126 0.00001
NM_000249.4(MLH1):c.1236C>T (p.Val412=) rs369576099 0.00001
NM_000249.4(MLH1):c.1238C>T (p.Thr413Ile) rs63750766 0.00001
NM_000249.4(MLH1):c.1327A>C (p.Lys443Gln) rs34213726 0.00001
NM_000249.4(MLH1):c.1410-7A>G rs1057521233 0.00001
NM_000249.4(MLH1):c.1460G>A (p.Arg487Gln) rs587778917 0.00001
NM_000249.4(MLH1):c.1506C>T (p.Asn502=) rs997236053 0.00001
NM_000249.4(MLH1):c.1512T>C (p.Thr504=) rs749683911 0.00001
NM_000249.4(MLH1):c.1519T>C (p.Leu507=) rs864622718 0.00001
NM_000249.4(MLH1):c.1551A>G (p.Gly517=) rs373322226 0.00001
NM_000249.4(MLH1):c.1558+10C>T rs765913871 0.00001
NM_000249.4(MLH1):c.1558+4C>T rs531873434 0.00001
NM_000249.4(MLH1):c.1632A>G (p.Gln544=) rs1553658111 0.00001
NM_000249.4(MLH1):c.1647T>C (p.Leu549=) rs768770694 0.00001
NM_000249.4(MLH1):c.1665T>C (p.Leu555=) rs749204990 0.00001
NM_000249.4(MLH1):c.1731+14C>G rs745643356 0.00001
NM_000249.4(MLH1):c.1800A>G (p.Glu600=) rs1394666357 0.00001
NM_000249.4(MLH1):c.1878C>T (p.Phe626=) rs63751214 0.00001
NM_000249.4(MLH1):c.1896+17T>C rs193922368 0.00001
NM_000249.4(MLH1):c.1896+7C>T rs863224339 0.00001
NM_000249.4(MLH1):c.1897-7C>T rs373078652 0.00001
NM_000249.4(MLH1):c.1902G>A (p.Gly634=) rs376866470 0.00001
NM_000249.4(MLH1):c.1950G>A (p.Leu650=) rs1064793176 0.00001
NM_000249.4(MLH1):c.1989+12A>G rs755976424 0.00001
NM_000249.4(MLH1):c.1989+14C>T rs763711727 0.00001
NM_000249.4(MLH1):c.1989+18T>C rs1057521681 0.00001
NM_000249.4(MLH1):c.1990-6G>A rs117221851 0.00001
NM_000249.4(MLH1):c.2034A>G (p.Lys678=) rs894876691 0.00001
NM_000249.4(MLH1):c.2070C>T (p.Tyr690=) rs550890395 0.00001
NM_000249.4(MLH1):c.208-9A>G rs1057523558 0.00001
NM_000249.4(MLH1):c.2082G>A (p.Glu694=) rs1057521441 0.00001
NM_000249.4(MLH1):c.2094A>G (p.Ser698=) rs786202433 0.00001
NM_000249.4(MLH1):c.2103+6G>T rs1057521607 0.00001
NM_000249.4(MLH1):c.2190T>C (p.Pro730=) rs1057521673 0.00001
NM_000249.4(MLH1):c.21T>C (p.Val7=) rs781725830 0.00001
NM_000249.4(MLH1):c.222T>C (p.Asp74=) rs755073786 0.00001
NM_000249.4(MLH1):c.24T>A (p.Ile8=) rs748406142 0.00001
NM_000249.4(MLH1):c.27G>T (p.Arg9=) rs759680369 0.00001
NM_000249.4(MLH1):c.306+15C>G rs1047862390 0.00001
NM_000249.4(MLH1):c.306+3A>G rs267607731 0.00001
NM_000249.4(MLH1):c.30G>T (p.Arg10=) rs876660759 0.00001
NM_000249.4(MLH1):c.351G>A (p.Thr117=) rs61751643 0.00001
NM_000249.4(MLH1):c.453+11T>C rs202061242 0.00001
NM_000249.4(MLH1):c.454-15C>T rs372959218 0.00001
NM_000249.4(MLH1):c.454-6G>A rs781238673 0.00001
NM_000249.4(MLH1):c.483G>A (p.Thr161=) rs776402672 0.00001
NM_000249.4(MLH1):c.51C>T (p.Asn17=) rs761498953 0.00001
NM_000249.4(MLH1):c.531G>A (p.Leu177=) rs1386646525 0.00001
NM_000249.4(MLH1):c.534A>G (p.Glu178=) rs786202121 0.00001
NM_000249.4(MLH1):c.545+10A>C rs781569222 0.00001
NM_000249.4(MLH1):c.546-9C>T rs878853789 0.00001
NM_000249.4(MLH1):c.563C>T (p.Ala188Val) rs777971431 0.00001
NM_000249.4(MLH1):c.573T>C (p.Ser191=) rs754102133 0.00001
NM_000249.4(MLH1):c.589-13G>A rs757462513 0.00001
NM_000249.4(MLH1):c.636C>T (p.Thr212=) rs138735345 0.00001
NM_000249.4(MLH1):c.790+18A>T rs771260579 0.00001
NM_000249.4(MLH1):c.791-14T>C rs751254837 0.00001
NM_000249.4(MLH1):c.791-15C>T rs779679241 0.00001
NM_000249.4(MLH1):c.791-20G>C rs758248283 0.00001
NM_000249.4(MLH1):c.885-5G>T rs267607802 0.00001
NM_000249.4(MLH1):c.918T>C (p.Asn306=) rs587779054 0.00001
NM_000249.4(MLH1):c.990C>T (p.Ile330=) rs372578171 0.00001
NM_000249.3(MLH1):c.-34A>C rs780702356
NM_000249.4(MLH1):c.*158GATT[1] rs796807655
NM_000249.4(MLH1):c.1038+20A>G rs1057523151
NM_000249.4(MLH1):c.1038+6G>A rs1553648244
NM_000249.4(MLH1):c.1039-31_1039-24del rs755745938
NM_000249.4(MLH1):c.1039-31_1039-25del rs563315461
NM_000249.4(MLH1):c.1039-31_1039-26del rs1178900468
NM_000249.4(MLH1):c.1039-6del rs1553650466
NM_000249.4(MLH1):c.1039-844_1039-842del rs59905922
NM_000249.4(MLH1):c.1039-9T>A rs1060504009
NM_000249.4(MLH1):c.1062C>G (p.Gly354=) rs730881748
NM_000249.4(MLH1):c.1095T>C (p.Ser365=) rs746800098
NM_000249.4(MLH1):c.1117G>A (p.Gly373Arg) rs766904735
NM_000249.4(MLH1):c.114C>T (p.Asn38=) rs267607706
NM_000249.4(MLH1):c.116+12G>A rs1057524003
NM_000249.4(MLH1):c.116+6G>A rs1057522127
NM_000249.4(MLH1):c.117-43_117-39del rs587778895
NM_000249.4(MLH1):c.117-9A>G rs1060504004
NM_000249.4(MLH1):c.1212G>C (p.Leu404=) rs1378785019
NM_000249.4(MLH1):c.1266C>T (p.Gly422=) rs63750791
NM_000249.4(MLH1):c.1268G>A (p.Arg423Lys) rs370687064
NM_000249.4(MLH1):c.1365T>A (p.Thr455=) rs753671152
NM_000249.4(MLH1):c.1371A>G (p.Glu457=) rs878853776
NM_000249.4(MLH1):c.1380G>A (p.Glu460=) rs1057523053
NM_000249.4(MLH1):c.1409+1153C>T rs116685008
NM_000249.4(MLH1):c.1409+13G>C rs1553651613
NM_000249.4(MLH1):c.1409+15G>A rs1553651615
NM_000249.4(MLH1):c.1410-14T>C rs750125270
NM_000249.4(MLH1):c.1410-254G>A rs9282784
NM_000249.4(MLH1):c.1410-4G>T rs1057520517
NM_000249.4(MLH1):c.1410-8C>T rs1057521668
NM_000249.4(MLH1):c.1476A>C (p.Ala492=) rs864622619
NM_000249.4(MLH1):c.1558+11G>A rs267607833
NM_000249.4(MLH1):c.1558+6T>C rs730881749
NM_000249.4(MLH1):c.1559-9G>C rs762630771
NM_000249.4(MLH1):c.1569G>T (p.Glu523Asp) rs63751680
NM_000249.4(MLH1):c.1618T>C (p.Leu540=) rs1448439825
NM_000249.4(MLH1):c.1667+14GT[2] rs1064794546
NM_000249.4(MLH1):c.1667+248TTTG[6] rs3067695
NM_000249.4(MLH1):c.1668-20_1668-19inv
NM_000249.4(MLH1):c.1668-7T>C rs1057521427
NM_000249.4(MLH1):c.172T>C (p.Leu58=) rs1057522380
NM_000249.4(MLH1):c.1731+247C>T rs116628044
NM_000249.4(MLH1):c.1743G>C (p.Pro581=) rs567838745
NM_000249.4(MLH1):c.1743G>T (p.Pro581=) rs567838745
NM_000249.4(MLH1):c.1815A>G (p.Glu605=) rs767748815
NM_000249.4(MLH1):c.1818A>T (p.Gly606=) rs1057522427
NM_000249.4(MLH1):c.1824T>G (p.Ala608=) rs876659019
NM_000249.4(MLH1):c.1848G>A (p.Lys616=) rs1553663004
NM_000249.4(MLH1):c.1853A>G (p.Lys618Arg) rs63750449
NM_000249.4(MLH1):c.1854G>A (p.Lys618=) rs786202638
NM_000249.4(MLH1):c.1896+18A>T rs760744040
NM_000249.4(MLH1):c.1897-14T>C rs730881751
NM_000249.4(MLH1):c.1929T>C (p.Ile643=) rs1553663862
NM_000249.4(MLH1):c.1944C>A (p.Pro648=) rs1553663936
NM_000249.4(MLH1):c.1948T>C (p.Leu650=) rs1057522855
NM_000249.4(MLH1):c.1953G>A (p.Glu651=) rs878853784
NM_000249.4(MLH1):c.1986T>C (p.Thr662=) rs1057523659
NM_000249.4(MLH1):c.1989+17A>C rs1057521609
NM_000249.4(MLH1):c.1989+20C>T rs753439477
NM_000249.4(MLH1):c.1989+20_1989+22del rs751549454
NM_000249.4(MLH1):c.1990-17G>C rs1057521535
NM_000249.4(MLH1):c.2040C>T (p.Cys680=) rs63749867
NM_000249.4(MLH1):c.2043T>C (p.Ala681=) rs768595157
NM_000249.4(MLH1):c.204C>T (p.Ile68=) rs780141938
NM_000249.4(MLH1):c.2064G>A (p.Lys688=) rs1057523316
NM_000249.4(MLH1):c.207+19T>C rs544141964
NM_000249.4(MLH1):c.2074T>C (p.Ser692Pro) rs587779957
NM_000249.4(MLH1):c.208-11G>C rs1553640173
NM_000249.4(MLH1):c.2088C>G (p.Thr696=) rs1060504015
NM_000249.4(MLH1):c.2091C>T (p.Leu697=) rs536488280
NM_000249.4(MLH1):c.2103+18A>G rs1057520315
NM_000249.4(MLH1):c.2104-11G>C rs147984696
NM_000249.4(MLH1):c.2104-14A>G rs1553665451
NM_000249.4(MLH1):c.2121C>T (p.Ser707=) rs886038273
NM_000249.4(MLH1):c.2184T>A (p.Ile728=) rs1057524100
NM_000249.4(MLH1):c.2193T>C (p.Pro731=) rs749082864
NM_000249.4(MLH1):c.2205A>G (p.Thr735=) rs371263535
NM_000249.4(MLH1):c.228A>G (p.Val76=) rs767750489
NM_000249.4(MLH1):c.253C>T (p.Leu85=) rs63750659
NM_000249.4(MLH1):c.306+17A>T rs1057523893
NM_000249.4(MLH1):c.307-10T>C rs572853043
NM_000249.4(MLH1):c.31C>T (p.Leu11=) rs864622596
NM_000249.4(MLH1):c.342T>C (p.Thr114=) rs1057520553
NM_000249.4(MLH1):c.380+10T>C rs1553641403
NM_000249.4(MLH1):c.380+16C>G rs121909452
NM_000249.4(MLH1):c.380+17T>C rs953236969
NM_000249.4(MLH1):c.381-119_381-116del rs4647243
NM_000249.4(MLH1):c.381-13_381-12del rs750589024
NM_000249.4(MLH1):c.381-14T>C rs1057522526
NM_000249.4(MLH1):c.453+12A>G rs1553642175
NM_000249.4(MLH1):c.453+17G>A rs1553642181
NM_000249.4(MLH1):c.454-6G>T rs781238673
NM_000249.4(MLH1):c.516A>G (p.Glu172=) rs748128054
NM_000249.4(MLH1):c.546-5del rs1553643965
NM_000249.4(MLH1):c.558C>T (p.His186=) rs63751050
NM_000249.4(MLH1):c.576C>T (p.Phe192=) rs1553644032
NM_000249.4(MLH1):c.588+18G>A rs1553644071
NM_000249.4(MLH1):c.589-9G>T rs566497442
NM_000249.4(MLH1):c.589-9_589-6del rs587779026
NM_000249.4(MLH1):c.589-9_589-7delinsATC rs1553644107
NM_000249.4(MLH1):c.600A>G (p.Thr200=) rs1057522574
NM_000249.4(MLH1):c.654C>T (p.Ser218=) rs876660372
NM_000249.4(MLH1):c.677+16A>T rs1553644288
NM_000249.4(MLH1):c.677+17T>C rs758227122
NM_000249.4(MLH1):c.677+20A>G rs1354439770
NM_000249.4(MLH1):c.678A>T (p.Arg226=) rs786203360
NM_000249.4(MLH1):c.711C>T (p.Thr237=) rs1057523923
NM_000249.4(MLH1):c.723A>G (p.Lys241=) rs1057521605
NM_000249.4(MLH1):c.780C>T (p.Leu260=) rs587779038
NM_000249.4(MLH1):c.840T>C (p.Tyr280=) rs63750938
NM_000249.4(MLH1):c.876G>A (p.Leu292=) rs773452312
NM_000249.4(MLH1):c.884+12C>T rs1057521390
NM_000249.4(MLH1):c.885-12T>C rs1575508554
NM_000249.4(MLH1):c.885-17T>C rs1057522076
NM_000249.4(MLH1):c.885-18_885-15del rs267607804
NM_000249.4(MLH1):c.885-19_885-18delinsCT rs1064795385
NM_000249.4(MLH1):c.885-21TC[2] rs267607804
NM_000249.4(MLH1):c.885-8C>T rs762836160
NM_000249.4(MLH1):c.91_92delinsTG (p.Ala31Cys) rs63749994
NM_000249.4(MLH1):c.927C>T (p.Pro309=) rs63749896

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