ClinVar Miner

Variants in gene MLH3

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
4 4 411 132 47 554

Condition and significance breakdown #

Total conditions: 15
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Condition pathogenic likely pathogenic uncertain significance likely benign benign total
Hereditary nonpolyposis colorectal cancer type 7 2 1 399 110 45 522
not provided 0 2 5 28 1 36
not specified 0 0 5 11 12 27
Lynch syndrome 0 0 6 1 0 7
Colorectal cancer, non-polyposis 0 0 2 1 0 3
Colorectal cancer 1 0 1 0 0 2
Breast carcinoma 0 0 1 0 0 1
Carcinoma of colon 1 0 0 0 0 1
Endometrial cancer 1 0 0 0 0 1
Endometrial carcinoma 0 0 0 1 0 1
Endometrial carcinoma; Hereditary nonpolyposis colorectal cancer type 7 0 0 1 0 0 1
Hereditary cancer 0 0 1 0 0 1
Lynch syndrome II 0 0 0 1 0 1
Malignant tumor of breast 0 0 0 1 0 1
Premature ovarian failure 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 18
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
Invitae 0 0 323 89 38 450
Illumina Clinical Services Laboratory,Illumina 0 0 91 35 13 139
Mayo Clinic Laboratories, Mayo Clinic 0 2 5 11 9 27
Department of Pathology and Laboratory Medicine,Sinai Health System 0 0 3 6 3 12
OMIM 3 0 4 0 0 7
CSER _CC_NCGL, University of Washington 0 0 4 1 0 5
PreventionGenetics, PreventionGenetics 0 0 0 0 3 3
GeneDx 0 0 2 0 0 2
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 2 1 0 2
Baylor Genetics 0 0 1 0 0 1
Fulgent Genetics,Fulgent Genetics 0 0 1 0 0 1
Center for Individualized Medicine,Mayo Clinic 0 1 0 0 0 1
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 0 1 0 1
Center of Medical Genetics and Primary Health Care 0 0 0 1 0 1
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 0 0 1 0 0 1
Institute of Human Genetics, University of Leipzig Medical Center 0 0 0 1 0 1
Medical Cytogenetics and Molecular Genetics Laboratory,IRCCS Istituto Auxologico Italiano 0 1 0 0 0 1
Genomic Center,National Cancer Institute 1 0 0 0 0 1

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