ClinVar Miner

Variants in gene MRE11

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
65 47 738 281 43 1 23 19 1128

Condition and significance breakdown #

Total conditions: 11
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Condition pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
Hereditary cancer-predisposing syndrome 48 28 529 214 10 0 0 0 820
Ataxia-telangiectasia-like disorder 25 13 277 75 18 0 0 0 408
Ataxia-telangiectasia-like disorder 1 12 12 178 24 25 0 0 1 238
not provided 3 8 50 46 17 0 0 18 133
not specified 0 0 15 13 22 0 0 0 43
Urinary bladder cancer 0 0 0 0 0 0 23 0 23
Hereditary breast and ovarian cancer syndrome 0 1 11 0 0 0 0 0 12
Dystonia; Depressivity; Parkinsonism; Dementia 0 0 2 0 0 0 0 0 2
Neoplasm of ovary 0 0 1 0 0 0 0 0 1
Premature ovarian insufficiency 0 0 1 0 0 0 0 0 1
Triple-negative breast cancer 0 0 0 0 0 1 0 0 1

Submitter and significance breakdown #

Total submitters: 39
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
Ambry Genetics 45 28 504 205 8 0 0 0 790
Invitae 27 13 335 109 18 0 0 0 501
Illumina Clinical Services Laboratory,Illumina 0 1 106 8 18 0 0 0 133
Athena Diagnostics Inc 1 3 23 7 14 0 0 0 48
GeneDx 1 1 22 2 10 0 0 0 36
Integrated Genetics/Laboratory Corporation of America 1 0 10 6 18 0 0 0 35
Counsyl 1 2 6 9 9 0 0 0 27
Gray Institute for Radiation Oncology & Biology, University of Oxford 0 0 0 0 0 0 23 0 23
Harris Lab, University of Minnesota 0 0 0 0 0 0 0 18 18
Fulgent Genetics,Fulgent Genetics 0 0 17 0 0 0 0 0 17
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 7 3 5 0 0 0 15
CeGaT Praxis fuer Humangenetik Tuebingen 1 4 9 1 0 0 0 0 15
GeneKor MSA 0 0 13 0 0 0 0 0 13
Baylor Genetics 2 0 9 0 0 0 0 0 11
University of Washington Department of Laboratory Medicine, University of Washington 0 0 3 8 0 0 0 0 11
Cancer Genomics Group,Japanese Foundation For Cancer Research 0 0 10 0 0 0 0 0 10
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 1 0 1 3 4 0 0 0 9
OMIM 6 0 0 0 0 0 0 0 6
PreventionGenetics, PreventionGenetics 0 0 0 0 6 0 0 0 6
Institute of Human Genetics, Klinikum rechts der Isar 1 3 0 0 0 0 0 0 4
Genetic Services Laboratory, University of Chicago 0 0 1 2 0 0 0 0 3
Mendelics 2 1 0 0 0 0 0 0 3
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 3 0 0 0 0 0 3
Genome Diagnostics Laboratory,University Medical Center Utrecht 0 0 0 2 0 0 0 0 2
Undiagnosed Diseases Network,NIH 1 1 0 0 0 0 0 0 2
Department of Pathology and Laboratory Medicine,Sinai Health System 0 0 2 0 0 0 0 0 2
Genome Diagnostics Laboratory,VU University Medical Center Amsterdam 0 0 0 1 1 0 0 0 2
Biochemical Molecular Genetic Laboratory,King Abdulaziz Medical City 1 0 1 0 0 0 0 0 2
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 0 0 0 1 0 0 0 1
UCLA Clinical Genomics Center, UCLA 0 1 0 0 0 0 0 0 1
Molecular Oncology Laboratory,Centre Jean Perrin 0 0 0 0 0 1 0 0 1
Dr. Peter K. Rogan Lab,Western University 0 1 0 0 0 0 0 0 1
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 1 0 0 0 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 0 0 1 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 0 0 1
Reproductive Development, Murdoch Childrens Research Institute 0 0 1 0 0 0 0 0 1
DNA and Cytogenetics Diagnostics Unit,Erasmus Medical Center 0 0 0 1 0 0 0 0 1
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 0 1 0 0 0 0 0 0 1
Molecular Oncology Research Center,Barretos Cancer Hospital 0 0 1 0 0 0 0 0 1

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