ClinVar Miner

Variants in gene MRE11

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
42 35 517 215 31 1 23 18 818

Condition and significance breakdown #

Total conditions: 13
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Condition pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
Hereditary cancer-predisposing syndrome 36 20 389 155 10 0 0 0 602
Ataxia-telangiectasia-like disorder 1 12 12 160 31 12 0 0 0 217
not provided 2 5 48 77 22 0 0 18 159
Ataxia-telangiectasia-like disorder 6 1 85 0 0 0 0 0 92
not specified 0 0 10 10 18 0 0 0 32
Bladder cancer, somatic 0 0 0 0 0 0 23 0 23
Dystonia; Depressivity; Parkinsonism; Dementia 0 0 2 0 0 0 0 0 2
Ovarian Neoplasms 2 0 0 0 0 0 0 0 2
Hereditary breast and ovarian cancer syndrome 0 1 0 0 0 0 0 0 1
Neoplasm of ovary 0 0 1 0 0 0 0 0 1
Premature ovarian insufficiency 0 0 1 0 0 0 0 0 1
Triple-negative breast cancer 0 0 0 0 0 1 0 0 1
Tumor susceptibility linked to germline BAP1 mutations 1 0 0 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 35
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
Ambry Genetics 34 20 355 146 8 0 0 0 562
Invitae 13 6 214 86 18 0 0 0 337
Illumina Clinical Services Laboratory,Illumina 0 1 61 10 2 0 0 0 74
Athena Diagnostics Inc 1 2 23 4 8 0 0 0 38
GeneDx 1 2 22 2 10 0 0 0 37
Counsyl 1 2 6 9 9 0 0 0 27
Integrated Genetics/Laboratory Corporation of America 0 0 5 3 16 0 0 0 24
Gray Institute for Radiation Oncology & Biology, University of Oxford 0 0 0 0 0 0 23 0 23
Harris Lab, University of Minnesota 0 0 0 0 0 0 0 18 18
Fulgent Genetics,Fulgent Genetics 0 0 17 0 0 0 0 0 17
GeneKor MSA 0 0 13 0 0 0 0 0 13
CeGaT Praxis fuer Humangenetik Tuebingen 0 2 8 1 0 0 0 0 11
University of Washington Department of Laboratory Medicine,University of Washington 0 0 3 8 0 0 0 0 11
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 1 0 1 3 4 0 0 0 9
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 6 2 0 0 0 0 8
OMIM 6 0 0 0 0 0 0 0 6
PreventionGenetics,PreventionGenetics 0 0 0 0 6 0 0 0 6
Genetic Services Laboratory, University of Chicago 0 0 1 2 0 0 0 0 3
Mendelics 2 1 0 0 0 0 0 0 3
Institute of Human Genetics,Klinikum rechts der Isar 0 3 0 0 0 0 0 0 3
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 3 0 0 0 0 0 3
Genome Diagnostics Laboratory,University Medical Center Utrecht 0 0 0 2 0 0 0 0 2
Undiagnosed Diseases Network,NIH 1 1 0 0 0 0 0 0 2
Genome Diagnostics Laboratory,VU University Medical Center Amsterdam 0 0 0 1 1 0 0 0 2
Biochemical Molecular Genetic Laboratory,King Abdulaziz Medical City 1 0 1 0 0 0 0 0 2
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne 2 0 0 0 0 0 0 0 2
Baylor Genetics 1 0 0 0 0 0 0 0 1
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine 0 0 0 0 1 0 0 0 1
UCLA Clinical Genomics Center, UCLA 0 1 0 0 0 0 0 0 1
Molecular Oncology Laboratory,Centre Jean Perrin 0 0 0 0 0 1 0 0 1
Dr. Peter K. Rogan Lab,Western University 0 1 0 0 0 0 0 0 1
Equipe Genetique des Anomalies du Developpement,Université de Bourgogne 1 0 0 0 0 0 0 0 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 0 0 1
Reproductive Development, Murdoch Childrens Research Institute 0 0 1 0 0 0 0 0 1
DNA and Cytogenetics Diagnostics Unit,Erasmus Medical Center 0 0 0 1 0 0 0 0 1

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