ClinVar Miner

Variants in gene MRE11

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
40 32 493 204 30 1 23 18 776

Condition and significance breakdown #

Total conditions: 12
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Condition pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
Hereditary cancer-predisposing syndrome 36 21 391 172 12 0 0 0 620
Ataxia-telangiectasia-like disorder 1 11 8 195 49 18 0 0 0 265
not provided 2 4 34 4 11 0 0 18 68
not specified 0 0 13 9 18 0 0 0 34
Bladder cancer, somatic 0 0 0 0 0 0 23 0 23
Dystonia; Depressivity; Parkinsonism; Dementia 0 0 2 0 0 0 0 0 2
Ovarian Neoplasms 2 0 0 0 0 0 0 0 2
Hereditary breast and ovarian cancer syndrome 0 1 0 0 0 0 0 0 1
Neoplasm of ovary 0 0 1 0 0 0 0 0 1
Premature ovarian insufficiency 0 0 1 0 0 0 0 0 1
Triple-negative breast cancer 0 0 0 0 0 1 0 0 1
Tumor susceptibility linked to germline BAP1 mutations 1 0 0 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 30
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
Ambry Genetics 34 20 355 146 8 0 0 0 562
Invitae 9 6 179 64 16 0 0 0 274
Illumina Clinical Services Laboratory,Illumina 0 1 61 10 2 0 0 0 74
GeneDx 1 2 22 2 10 0 0 0 37
Counsyl 1 2 6 9 9 0 0 0 27
Integrated Genetics/Laboratory Corporation of America 0 0 6 2 16 0 0 0 24
Gray Institute for Radiation Oncology & Biology, University of Oxford 0 0 0 0 0 0 23 0 23
Athena Diagnostics Inc 1 1 14 3 2 0 0 0 21
Harris Lab, University of Minnesota 0 0 0 0 0 0 0 18 18
Fulgent Genetics 0 0 17 0 0 0 0 0 17
GeneKor MSA 0 0 13 0 0 0 0 0 13
University of Washington Department of Laboratory Medicine,University of Washington 0 0 3 8 0 0 0 0 11
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 1 0 1 3 4 0 0 0 9
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 6 2 0 0 0 0 8
OMIM 6 0 0 0 0 0 0 0 6
PreventionGenetics 0 0 0 0 6 0 0 0 6
CeGaT Praxis fuer Humangenetik Tuebingen 0 2 2 0 0 0 0 0 4
Genetic Services Laboratory, University of Chicago 0 0 1 2 0 0 0 0 3
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 3 0 0 0 0 0 3
Genome Diagnostics Laboratory,University Medical Center Utrecht 0 0 0 2 0 0 0 0 2
Genome Diagnostics Laboratory,VU University Medical Center Amsterdam 0 0 0 1 1 0 0 0 2
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne 2 0 0 0 0 0 0 0 2
Baylor Genetics 1 0 0 0 0 0 0 0 1
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 0 0 0 1 0 0 0 1
UCLA Clinical Genomics Center, UCLA 0 1 0 0 0 0 0 0 1
Molecular Oncology Laboratory,Centre Jean Perrin 0 0 0 0 0 1 0 0 1
Dr. Peter K. Rogan Lab,Western University 0 1 0 0 0 0 0 0 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 0 0 1
Molecular Development Laboratory,Murdoch Childrens Research Institute 0 0 1 0 0 0 0 0 1
DNA and Cytogenetics Diagnostics Unit,Erasmus Medical Center 0 0 0 1 0 0 0 0 1

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