ClinVar Miner

List of variants in gene MSH2 reported as benign for Lynch syndrome

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Total variants: 51
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HGVS dbSNP gnomAD frequency
NM_000251.3(MSH2):c.2210+317G>C rs4638843 0.92052
NM_000251.3(MSH2):c.211+9C>G rs2303426 0.55454
NM_000251.3(MSH2):c.211+98T>C rs3815865 0.55408
NM_000251.3(MSH2):c.1276+6765G>A rs3771274 0.53492
NM_000251.3(MSH2):c.1077-80G>A rs2347794 0.53152
NM_000251.3(MSH2):c.1511-1516C>T rs3771281 0.48800
NM_000251.3(MSH2):c.2006-265A>G rs2059520 0.48792
NM_000251.2(MSH2):c.*272+4059G>A rs6720549 0.43302
NM_000251.3(MSH2):c.1511-91G>T rs3732182 0.41551
NM_000251.3(MSH2):c.1661+12G>A rs3732183 0.40290
NM_000251.3(MSH2):c.1277-212T>A rs1981928 0.39571
NM_001406631.1(MSH2):c.2634+4770A>C rs6544991 0.21374
NM_000251.3(MSH2):c.2210+274T>G rs4608577 0.19234
NM_000251.1(MSH2):c.-433T>G rs1863332 0.11834
NM_000251.2(MSH2):c.-118T>C rs2303425 0.10354
NM_000251.3(MSH2):c.1076+3400C>T rs4952887 0.10157
NM_000251.3(MSH2):c.1277-6990T>G rs13408008 0.10114
NM_000251.3(MSH2):c.2635-214T>C rs2042649 0.09372
NM_000251.3(MSH2):c.1759+501A>G rs17036614 0.09371
NM_000251.3(MSH2):c.1511-9A>T rs12998837 0.09123
NM_000251.3(MSH2):c.1277-5849T>C rs17036577 0.08736
NM_000251.3(MSH2):c.2006-6T>C rs2303428 0.08349
NM_000251.3(MSH2):c.1387-250G>A rs6741393 0.04348
NM_000251.3(MSH2):c.1661+90T>C rs10183143 0.03147
NM_000251.3(MSH2):c.1077-2037G>T rs13425206 0.03061
NM_000251.3(MSH2):c.1760-62G>A rs17218439 0.02701
NM_000251.3(MSH2):c.380A>G (p.Asn127Ser) rs17217772 0.02317
NM_000251.3(MSH2):c.573C>T (p.Leu191=) rs1800151 0.01972
NM_000251.3(MSH2):c.1276+51C>A rs17217961 0.01831
NM_000251.3(MSH2):c.965G>A (p.Gly322Asp) rs4987188 0.01714
NM_000251.3(MSH2):c.1077-10T>C rs17224360 0.01428
NM_000251.3(MSH2):c.1666T>C (p.Leu556=) rs61756466 0.00471
NM_000251.3(MSH2):c.1662-9G>A rs17218356 0.00398
NM_000251.3(MSH2):c.339G>A (p.Lys113=) rs35898375 0.00313
NM_000251.3(MSH2):c.23C>T (p.Thr8Met) rs17217716 0.00184
NM_000251.3(MSH2):c.1387-8G>T rs187525243 0.00143
NM_000251.3(MSH2):c.1737A>G (p.Lys579=) rs61756467 0.00138
NM_000251.3(MSH2):c.815C>T (p.Ala272Val) rs34136999 0.00046
NM_000251.3(MSH2):c.*129T>C rs587779059 0.00042
NM_000251.3(MSH2):c.1886A>G (p.Gln629Arg) rs61756468 0.00042
NM_000251.3(MSH2):c.1168C>T (p.Leu390Phe) rs17224367 0.00039
NM_000251.3(MSH2):c.317G>A (p.Arg106Lys) rs41295286 0.00009
NM_000251.3(MSH2):c.1690A>G (p.Thr564Ala) rs55778204 0.00008
NM_000251.3(MSH2):c.1277-118G>A rs1981929
NM_000251.3(MSH2):c.1277-945A>C rs7607312
NM_000251.3(MSH2):c.2355T>C (p.His785=) rs1114167840
NM_000251.3(MSH2):c.273TCT[2] (p.Leu94del) rs267607919
NM_000251.3(MSH2):c.593A>G (p.Glu198Gly) rs63750327
NM_000251.3(MSH2):c.7G>T (p.Val3Leu) rs1257347271
NM_000251.3(MSH2):c.942+17_942+29del rs11309117
NM_000251.3(MSH2):c.942+25_942+29del rs11309117

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