ClinVar Miner

List of variants in gene MSH6 reported as uncertain significance by International Society for Gastrointestinal Hereditary Tumours (InSiGHT)

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Gene type:
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Total variants: 205
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HGVS dbSNP
MHS6:c.3647-65_3647-61del rs3136363
NM_000179.2(MSH6):c.*24_*28delGTTGA rs587779200
NM_000179.2(MSH6):c.-13022_-1711del
NM_000179.2(MSH6):c.-18G>T rs199913053
NM_000179.2(MSH6):c.-8C>T rs565211544
NM_000179.2(MSH6):c.1044C>A (p.Ser348=) rs587779202
NM_000179.2(MSH6):c.1079G>T (p.Ser360Ile) rs267608060
NM_000179.2(MSH6):c.1082G>A (p.Arg361His) rs63750440
NM_000179.2(MSH6):c.108T>G (p.Ala36=) rs63750213
NM_000179.2(MSH6):c.1109T>C (p.Leu370Ser) rs587779204
NM_000179.2(MSH6):c.1133G>A (p.Arg378Lys) rs587779205
NM_000179.2(MSH6):c.1144C>T (p.His382Tyr) rs587779207
NM_000179.2(MSH6):c.1153_1155delAGG (p.Arg385del) rs267608043
NM_000179.2(MSH6):c.124C>T (p.Pro42Ser) rs34014629
NM_000179.2(MSH6):c.1257G>A (p.Gln419=) rs63750026
NM_000179.2(MSH6):c.1272C>G (p.Val424=) rs63751452
NM_000179.2(MSH6):c.1273A>G (p.Ile425Val) rs63749971
NM_000179.2(MSH6):c.1304T>C (p.Leu435Pro) rs63751405
NM_000179.2(MSH6):c.1325T>C (p.Ile442Thr) rs587779210
NM_000179.2(MSH6):c.1338A>T (p.Glu446Asp) rs587779211
NM_000179.2(MSH6):c.1369G>C (p.Ala457Pro) rs267608052
NM_000179.2(MSH6):c.1402C>T (p.Arg468Cys) rs369456858
NM_000179.2(MSH6):c.1474A>G (p.Met492Val) rs61754783
NM_000179.2(MSH6):c.1547T>A (p.Ile516Asn) rs587779213
NM_000179.2(MSH6):c.1565A>G (p.Gln522Arg) rs63751009
NM_000179.2(MSH6):c.1569T>G (p.Thr523=) rs587779214
NM_000179.2(MSH6):c.1636G>C (p.Glu546Gln) rs63751172
NM_000179.2(MSH6):c.1676G>A (p.Cys559Tyr) rs63750595
NM_000179.2(MSH6):c.1677C>T (p.Cys559=) rs63749893
NM_000179.2(MSH6):c.1696G>A (p.Gly566Arg) rs63749973
NM_000179.2(MSH6):c.1729C>T (p.Arg577Cys) rs542838372
NM_000179.2(MSH6):c.1739C>T (p.Ser580Leu) rs41295270
NM_000179.2(MSH6):c.1754T>C (p.Leu585Pro) rs587779220
NM_000179.2(MSH6):c.1771C>T (p.Pro591Ser) rs267608045
NM_000179.2(MSH6):c.1830G>T (p.Lys610Asn) rs201735525
NM_000179.2(MSH6):c.1857A>C (p.Glu619Asp) rs63751121
NM_000179.2(MSH6):c.1867C>G (p.Pro623Ala) rs3136334
NM_000179.2(MSH6):c.1868C>T (p.Pro623Leu) rs63750462
NM_000179.2(MSH6):c.1932G>C (p.Arg644Ser) rs34938432
NM_000179.2(MSH6):c.1996T>C (p.Ser666Pro) rs587779222
NM_000179.2(MSH6):c.2006T>C (p.Ile669Thr) rs555209664
NM_000179.2(MSH6):c.2008G>A (p.Gly670Arg) rs63749857
NM_000179.2(MSH6):c.2025G>C (p.Glu675Asp) rs587779223
NM_000179.2(MSH6):c.2030G>C (p.Ser677Thr) rs587779224
NM_000179.2(MSH6):c.2045C>T (p.Ser682Phe) rs587779225
NM_000179.2(MSH6):c.2054G>C (p.Gly685Ala) rs63750358
NM_000179.2(MSH6):c.2080T>C (p.Cys694Arg) rs587779228
NM_000179.2(MSH6):c.2087T>C (p.Ile696Thr) rs587779229
NM_000179.2(MSH6):c.2092C>A (p.Gln698Lys) rs63750832
NM_000179.2(MSH6):c.2092C>G (p.Gln698Glu) rs63750832
NM_000179.2(MSH6):c.2098C>T (p.Leu700Phe) rs587779230
NM_000179.2(MSH6):c.2175C>G (p.Ile725Met) rs63750304
NM_000179.2(MSH6):c.2176_2177delTTinsAG (p.Phe726Ser) rs63750136
NM_000179.2(MSH6):c.2177T>A (p.Phe726Tyr) rs574358605
NM_000179.2(MSH6):c.2183A>C (p.Lys728Thr) rs35552856
NM_000179.2(MSH6):c.2239C>T (p.Leu747=) rs63751305
NM_000179.2(MSH6):c.2282G>A (p.Arg761Lys) rs587779233
NM_000179.2(MSH6):c.2295C>G (p.Cys765Trp) rs63750985
NM_000179.2(MSH6):c.2302_2304delCCT (p.Pro768del) rs63750647
NM_000179.2(MSH6):c.2329T>A (p.Trp777Arg) rs267608067
NM_000179.2(MSH6):c.2339C>G (p.Ala780Gly) rs63749899
NM_000179.2(MSH6):c.2341C>T (p.Pro781Ser) rs587779235
NM_000179.2(MSH6):c.2360C>T (p.Ala787Val) rs63750637
NM_000179.2(MSH6):c.2375T>C (p.Leu792Pro) rs587779236
NM_000179.2(MSH6):c.2392C>G (p.Leu798Val) rs587779238
NM_000179.2(MSH6):c.2400T>C (p.Val800=) rs267608071
NM_000179.2(MSH6):c.2408A>G (p.Asp803Gly) rs63751450
NM_000179.2(MSH6):c.2426_2428delTAG (p.Val809del) rs587779240
NM_000179.2(MSH6):c.2491C>G (p.Pro831Ala) rs267608053
NM_000179.2(MSH6):c.2549A>G (p.Tyr850Cys) rs63750389
NM_000179.2(MSH6):c.255C>A (p.Pro85=) rs587779242
NM_000179.2(MSH6):c.2561A>T (p.Lys854Met) rs34374438
NM_000179.2(MSH6):c.2597A>C (p.Lys866Thr) rs190075874
NM_000179.2(MSH6):c.260+101C>A rs267608030
NM_000179.2(MSH6):c.260+131C>A rs267608031
NM_000179.2(MSH6):c.260+25A>C rs267608027
NM_000179.2(MSH6):c.260+43G>A rs267608028
NM_000179.2(MSH6):c.260+96A>C rs267608029
NM_000179.2(MSH6):c.261-?_457+?dup
NM_000179.2(MSH6):c.2633T>G (p.Val878Gly) rs2020912
NM_000179.2(MSH6):c.2641delGinsAAAA (p.Gly881delinsLysSer) rs63751408
NM_000179.2(MSH6):c.2656A>G (p.Ile886Val) rs2020914
NM_000179.2(MSH6):c.2702G>A (p.Arg901His) rs63749889
NM_000179.2(MSH6):c.2739T>C (p.Asp913=) rs63750056
NM_000179.2(MSH6):c.2775A>C (p.Gly925=) rs587779248
NM_000179.2(MSH6):c.2825_2827delCTG (p.Ala942del) rs587779249
NM_000179.2(MSH6):c.2906A>C (p.Tyr969Ser) rs63749919
NM_000179.2(MSH6):c.2927G>A (p.Arg976His) rs63751113
NM_000179.2(MSH6):c.2955C>G (p.Phe985Leu) rs63750942
NM_000179.2(MSH6):c.297G>T (p.Lys99Asn) rs63751258
NM_000179.2(MSH6):c.3021G>C (p.Trp1007Cys) rs587779253
NM_000179.2(MSH6):c.3040_3042delAAG (p.Lys1014del) rs267608073
NM_000179.2(MSH6):c.3062C>A (p.Ala1021Asp) rs63750287
NM_000179.2(MSH6):c.3076G>T (p.Asp1026Tyr) rs267608054
NM_000179.2(MSH6):c.3163G>A (p.Ala1055Thr) rs587779254
NM_000179.2(MSH6):c.3173-18T>C rs189672273
NM_000179.2(MSH6):c.3206G>A (p.Gly1069Glu) rs63750784
NM_000179.2(MSH6):c.3218C>G (p.Pro1073Arg) rs587779257
NM_000179.2(MSH6):c.3245C>T (p.Pro1082Leu) rs191109849
NM_000179.2(MSH6):c.3259C>A (p.Pro1087Thr) rs63750998
NM_000179.2(MSH6):c.3259C>T (p.Pro1087Ser) rs63750998
NM_000179.2(MSH6):c.3260C>G (p.Pro1087Arg) rs63750753
NM_000179.2(MSH6):c.3284G>A (p.Arg1095His) rs63750253
NM_000179.2(MSH6):c.3299C>T (p.Thr1100Met) rs63750442
NM_000179.2(MSH6):c.3338T>G (p.Ile1113Ser)
NM_000179.2(MSH6):c.3383A>G (p.Tyr1128Cys) rs587779261
NM_000179.2(MSH6):c.3386_3388delGTG (p.Cys1129_Val1130delinsLeu) rs587776705
NM_000179.2(MSH6):c.3415G>A (p.Gly1139Ser) rs63751063
NM_000179.2(MSH6):c.3425C>T (p.Thr1142Met) rs267608089
NM_000179.2(MSH6):c.3437A>C (p.Gln1146Pro) rs587779262
NM_000179.2(MSH6):c.3438+11_3438+14delCTTA rs377746844
NM_000179.2(MSH6):c.3438+13dupT rs267608097
NM_000179.2(MSH6):c.3438+6T>C rs370170322
NM_000179.2(MSH6):c.3442G>C (p.Gly1148Arg) rs63750257
NM_000179.2(MSH6):c.3469G>A (p.Gly1157Ser) rs587779264
NM_000179.2(MSH6):c.3473_3475delGTT (p.Cys1158del) rs587779265
NM_000179.2(MSH6):c.3477C>T (p.Tyr1159=) rs398123231
NM_000179.2(MSH6):c.3478G>C (p.Val1160Leu) rs376799914
NM_000179.2(MSH6):c.3484G>C (p.Ala1162Pro) rs587779266
NM_000179.2(MSH6):c.3485_3487dupCTG (p.Ala1162_Glu1163insAla) rs63751427
NM_000179.2(MSH6):c.3513T>C (p.Asp1171=) rs63749834
NM_000179.2(MSH6):c.3517_3528delGTGTTTACTAGA (p.Val1173_Arg1176del) rs587779268
NM_000179.2(MSH6):c.3543C>G (p.Asp1181Glu) rs267608100
NM_000179.2(MSH6):c.3556+3_3556+13del rs587779269
NM_000179.2(MSH6):c.3556+64C>A rs587779270
NM_000179.2(MSH6):c.3557-2dup rs587779271
NM_000179.2(MSH6):c.3557-4delT rs267608102
NM_000179.2(MSH6):c.3558_3565delTGAAAGTA (p.Glu1187Ilefs) rs267608108
NM_000179.2(MSH6):c.3563G>A (p.Ser1188Asn) rs587779272
NM_000179.2(MSH6):c.3577G>A (p.Glu1193Lys) rs63751328
NM_000179.2(MSH6):c.3601C>G (p.Leu1201Val) rs182024561
NM_000179.2(MSH6):c.3605T>C (p.Met1202Thr) rs587779273
NM_000179.2(MSH6):c.3614C>T (p.Thr1205Ile) rs587779275
NM_000179.2(MSH6):c.362G>A (p.Arg121His) rs769279475
NM_000179.2(MSH6):c.363C>T (p.Arg121=) rs587779276
NM_000179.2(MSH6):c.3646+3_3646+4insT rs587779277
NM_000179.2(MSH6):c.3647-51_3647-35dup rs267607687
NM_000179.2(MSH6):c.3647-66_3647-61del rs587779281
NM_000179.2(MSH6):c.3650G>A (p.Arg1217Lys) rs63749898
NM_000179.2(MSH6):c.3656C>T (p.Thr1219Ile) rs63750949
NM_000179.2(MSH6):c.3674C>T (p.Thr1225Met) rs63750370
NM_000179.2(MSH6):c.3679A>T (p.Ile1227Leu) rs587779282
NM_000179.2(MSH6):c.3682G>C (p.Ala1228Pro) rs587779283
NM_000179.2(MSH6):c.3694G>C (p.Val1232Leu) rs41295276
NM_000179.2(MSH6):c.3694_3696delGTT (p.Val1232del) rs587779284
NM_000179.2(MSH6):c.3724C>A (p.Arg1242Ser) rs587779285
NM_000179.2(MSH6):c.3725G>T (p.Arg1242Leu) rs63750119
NM_000179.2(MSH6):c.3725_3727delGTA (p.Arg1242_Thr1243delinsPro) rs587779286
NM_000179.2(MSH6):c.3742C>G (p.His1248Asp) rs63750882
NM_000179.2(MSH6):c.3762A>T (p.Glu1254Asp) rs375459388
NM_000179.2(MSH6):c.3784G>C (p.Val1262Leu) rs587779290
NM_000179.2(MSH6):c.3787C>T (p.Arg1263Cys) rs367912290
NM_000179.2(MSH6):c.3801+17T>C rs3136365
NM_000179.2(MSH6):c.3801+38T>A rs587779292
NM_000179.2(MSH6):c.3802-42_3802-41insA rs267608116
NM_000179.2(MSH6):c.3803C>A (p.Ala1268Glu) rs587779293
NM_000179.2(MSH6):c.3820G>A (p.Glu1274Lys) rs587779294
NM_000179.2(MSH6):c.383G>T (p.Arg128Leu) rs63750143
NM_000179.2(MSH6):c.3851C>T (p.Thr1284Met) rs63750836
NM_000179.2(MSH6):c.3852G>A (p.Thr1284=) rs2229018
NM_000179.2(MSH6):c.38A>C (p.Lys13Thr) rs41294988
NM_000179.2(MSH6):c.3930G>C (p.Glu1310Asp) rs267608129
NM_000179.2(MSH6):c.3936T>C (p.Val1312=) rs61753796
NM_000179.2(MSH6):c.395A>C (p.Gln132Pro) rs587779298
NM_000179.2(MSH6):c.3961A>G (p.Arg1321Gly) rs41295278
NM_000179.2(MSH6):c.3963A>T (p.Arg1321Ser) rs267608125
NM_000179.2(MSH6):c.3969_4001+51dup rs1553333716
NM_000179.2(MSH6):c.3974_3976delAGA (p.Lys1325del) rs587779300
NM_000179.2(MSH6):c.4001+11_4001+15dupAACTA rs587779302
NM_000179.2(MSH6):c.4001+2_4001+5delTAAC rs267608132
NM_000179.2(MSH6):c.4001+32_4001+35dup rs267608136
NM_000179.2(MSH6):c.4001+34_4001+43dup rs1553333811
NM_000179.2(MSH6):c.4001+42_4001+45dup rs587779304
NM_000179.2(MSH6):c.4001+47T>C rs587779305
NM_000179.2(MSH6):c.4002-10T>A rs545466048
NM_000179.2(MSH6):c.4002-11_4002-10del rs59056100
NM_000179.2(MSH6):c.4002-22_4002-4del rs587779310
NM_000179.2(MSH6):c.4002-8dupA rs267608139
NM_000179.2(MSH6):c.4061T>A (p.Leu1354Gln) rs267608140
NM_000179.2(MSH6):c.4064_4065insGTCA (p.Leu1356Serfs) rs267608141
NM_000179.2(MSH6):c.440T>A (p.Leu147His) rs63750525
NM_000179.2(MSH6):c.457+14C>G rs267608033
NM_000179.2(MSH6):c.457+52_457+53dup rs397839804
NM_000179.2(MSH6):c.457+59_457+60del rs587779312
NM_000179.2(MSH6):c.457+63_457+64del rs267608034
NM_000179.2(MSH6):c.458-17A>G rs554847828
NM_000179.2(MSH6):c.483G>A (p.Lys161=) rs63751030
NM_000179.2(MSH6):c.498C>T (p.Tyr166=) rs587779313
NM_000179.2(MSH6):c.553A>G (p.Lys185Glu) rs193922344
NM_000179.2(MSH6):c.583G>T (p.Val195Phe) rs267608038
NM_000179.2(MSH6):c.603G>A (p.Glu201=) rs587779314
NM_000179.2(MSH6):c.62A>G (p.Asn21Ser) rs267608025
NM_000179.2(MSH6):c.648_649delAGinsTT (p.Asp217Tyr) rs63750471
NM_000179.2(MSH6):c.663A>C (p.Glu221Asp) rs41557217
NM_000179.2(MSH6):c.663A>G (p.Glu221=) rs41557217
NM_000179.2(MSH6):c.668A>G (p.Asn223Ser) rs587779316
NM_000179.2(MSH6):c.680G>T (p.Ser227Ile) rs587779317
NM_000179.2(MSH6):c.73G>T (p.Ala25Ser) rs267608026
NM_000179.2(MSH6):c.751A>G (p.Ile251Val) rs554884560
NM_000179.2(MSH6):c.753A>G (p.Ile251Met) rs587779321
NM_000179.2(MSH6):c.806C>G (p.Thr269Ser) rs587779322
NM_000179.2(MSH6):c.854G>T (p.Ser285Ile) rs63750878
NM_000179.2(MSH6):c.866_867delGCinsAA (p.Gly289Glu) rs267608079
NM_000179.2(MSH6):c.884A>G (p.Lys295Arg) rs267608051
NM_000179.2(MSH6):c.977C>T (p.Ala326Val) rs587779323

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