ClinVar Miner

Variants in gene NEXN

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
7 9 200 89 34 297

Condition and significance breakdown #

Total conditions: 20
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Condition pathogenic likely pathogenic uncertain significance likely benign benign total
Dilated cardiomyopathy 1CC; Familial hypertrophic cardiomyopathy 20 0 0 70 18 13 101
not specified 0 0 54 41 13 100
not provided 2 2 48 23 10 85
Cardiomyopathy 0 1 34 7 13 55
Cardiovascular phenotype 0 3 24 17 4 48
Hypertrophic cardiomyopathy 0 1 35 7 0 43
Dilated Cardiomyopathy, Dominant 0 0 33 7 0 40
Primary dilated cardiomyopathy 0 3 4 0 0 7
Primary familial hypertrophic cardiomyopathy 0 0 7 0 0 7
Dilated cardiomyopathy 1CC 3 1 1 1 0 6
Familial dilated cardiomyopathy 0 0 2 0 0 2
Familial hypertrophic cardiomyopathy 20 2 0 1 0 0 2
NEXN-Related Disorders 0 0 2 0 0 2
Arrhythmogenic right ventricular cardiomyopathy, type 9 0 0 1 0 0 1
Dilated cardiomyopathy 1S 0 1 0 0 0 1
Familial hypertrophic cardiomyopathy 1 0 0 1 0 0 1
Left ventricular hypertrophy 0 0 1 0 0 1
Left ventricular noncompaction cardiomyopathy 0 0 1 0 0 1
Long QT syndrome 0 0 0 1 0 1
Premature ventricular contraction 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 27
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
Invitae 0 0 67 36 14 117
GeneDx 2 2 44 33 23 104
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine 0 0 45 20 5 70
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario 0 1 32 7 12 52
Ambry Genetics 0 3 24 17 4 48
Illumina Clinical Services Laboratory,Illumina 0 0 35 7 0 42
Blueprint Genetics 0 1 8 1 0 10
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease,Montreal Heart Institute 0 0 7 1 1 9
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 5 0 1 6
Stanford Center for Inherited Cardiovascular Disease, Stanford University 0 0 6 0 0 6
OMIM 5 0 0 0 0 5
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 5 0 0 5
Center for Advanced Laboratory Medicine, UC San Diego Health,University of California San Diego 0 0 2 1 1 4
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 2 0 1 3
Genetics and Genomics Program,Sidra Medicine 0 3 0 0 0 3
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 0 0 2 0 0 2
Agnes Ginges Centre for Molecular Cardiology,Centenary Institute 0 0 2 0 0 2
Division of Human Genetics,Children's Hospital of Philadelphia 0 0 2 0 0 2
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development,Heart and Diabetes Center North Rhine-Westphalia 0 1 1 0 0 2
Klaassen Lab,Charite University Medicine Berlin 0 0 2 0 0 2
PreventionGenetics,PreventionGenetics 0 0 0 0 1 1
Mendelics 0 0 0 1 0 1
Fulgent Genetics,Fulgent Genetics 0 0 1 0 0 1
Center for Medical Genetics Ghent,University of Ghent 0 0 1 0 0 1
Soonchunhyang University Bucheon Hospital,Soonchunhyang University Medical Center 0 0 1 0 0 1
Bioscientia Institut fuer Medizinische Diagnostik GmbH,Sonic Healthcare 0 1 0 0 0 1
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 1 0 0 1

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