ClinVar Miner

Variants in gene NEXN

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
7 4 219 96 34 326

Condition and significance breakdown #

Total conditions: 23
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Condition pathogenic likely pathogenic uncertain significance likely benign benign total
Dilated cardiomyopathy 1CC; Familial hypertrophic cardiomyopathy 20 0 0 121 31 13 165
not specified 0 0 54 43 13 101
not provided 2 2 50 23 10 87
Cardiomyopathy 0 1 34 7 13 55
Cardiovascular phenotype 0 0 25 19 4 48
Dilated cardiomyopathy 1CC 3 2 7 1 0 12
Hypertrophic cardiomyopathy 0 0 8 2 0 10
Primary dilated cardiomyopathy 0 1 7 0 0 8
Primary familial hypertrophic cardiomyopathy 0 0 7 0 0 7
Dilated Cardiomyopathy, Dominant 0 0 4 1 0 5
Dilated cardiomyopathy 1A 0 0 4 0 0 4
Familial hypertrophic cardiomyopathy 20 2 0 3 0 0 4
Familial hypertrophic cardiomyopathy 1 0 0 3 0 0 3
none provided 0 0 1 0 2 3
Long QT syndrome 0 0 1 1 0 2
NEXN-Related Disorders 0 0 2 0 0 2
Primary familial dilated cardiomyopathy 0 0 2 0 0 2
Arrhythmogenic right ventricular dysplasia 9 0 0 1 0 0 1
Cardiomyopathy, left ventricular noncompaction 0 0 1 0 0 1
Dilated cardiomyopathy 1S 0 1 0 0 0 1
Inborn genetic diseases 0 0 1 0 0 1
Left ventricular hypertrophy 0 0 1 0 0 1
Premature ventricular contraction 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 32
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
Invitae 0 0 118 47 14 179
GeneDx 2 2 44 33 23 104
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 0 45 21 5 71
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario 0 1 32 7 12 52
Ambry Genetics 0 0 26 19 4 49
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease,Montreal Heart Institute 0 0 14 2 1 17
Blueprint Genetics 0 1 8 1 0 10
Illumina Clinical Services Laboratory,Illumina 0 0 6 1 0 7
Baylor Genetics 0 1 5 0 0 6
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 0 0 5 0 1 6
Stanford Center for Inherited Cardiovascular Disease, Stanford University 0 0 6 0 0 6
OMIM 5 0 0 0 0 5
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 5 0 0 5
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 2 0 2 4
Center for Advanced Laboratory Medicine, UC San Diego Health,University of California San Diego 0 0 2 1 1 4
Agnes Ginges Centre for Molecular Cardiology,Centenary Institute 0 0 3 0 0 3
Department of Pathology and Laboratory Medicine,Sinai Health System 0 0 3 0 0 3
Genetics and Genomics Program,Sidra Medicine 0 0 2 1 0 3
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 0 0 2 0 0 2
Division of Human Genetics,Children's Hospital of Philadelphia 0 0 2 0 0 2
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development,Heart and Diabetes Center North Rhine-Westphalia 0 1 1 0 0 2
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 2 0 0 2
Institute of Human Genetics, University of Leipzig Medical Center 0 0 2 0 0 2
Klaassen Lab,Charite University Medicine Berlin 0 0 2 0 0 2
PreventionGenetics, PreventionGenetics 0 0 0 0 1 1
Mendelics 0 0 0 1 0 1
Fulgent Genetics,Fulgent Genetics 0 0 1 0 0 1
Center for Medical Genetics Ghent,University of Ghent 0 0 1 0 0 1
University of Washington Center for Mendelian Genomics, University of Washington 0 0 1 0 0 1
Soonchunhyang University Bucheon Hospital,Soonchunhyang University Medical Center 0 0 1 0 0 1
Bioscientia Institut fuer Medizinische Diagnostik GmbH,Sonic Healthcare 0 1 0 0 0 1
Loeys Lab,Universiteit Antwerpen 0 0 1 0 0 1

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