ClinVar Miner

Variants in gene NEXN

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
7 6 178 66 20 241

Condition and significance breakdown #

Total conditions: 17
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Condition pathogenic likely pathogenic uncertain significance likely benign benign total
not specified 0 0 54 41 13 100
Dilated cardiomyopathy 1CC; Familial hypertrophic cardiomyopathy 20 0 0 42 16 11 69
Cardiovascular phenotype 0 3 28 13 4 48
not provided 2 2 44 0 0 48
Dilated Cardiomyopathy, Dominant 0 0 33 7 0 40
Hypertrophic cardiomyopathy 0 0 33 7 0 40
Cardiomyopathy 0 0 28 5 4 37
Dilated cardiomyopathy 1CC 3 1 1 0 0 5
Primary familial hypertrophic cardiomyopathy 0 0 5 0 0 5
Primary dilated cardiomyopathy 0 1 2 0 0 3
Familial hypertrophic cardiomyopathy 20 2 0 1 0 0 2
NEXN-Related Disorders 0 0 2 0 0 2
Arrhythmogenic right ventricular cardiomyopathy, type 9 0 0 1 0 0 1
Dilated cardiomyopathy 1S 0 1 0 0 0 1
Familial hypertrophic cardiomyopathy 1 0 0 1 0 0 1
Left ventricular hypertrophy 0 0 1 0 0 1
Left ventricular noncompaction cardiomyopathy 0 0 1 0 0 1

Submitter and significance breakdown #

Total submitters: 22
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
GeneDx 2 2 44 29 14 91
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 0 45 20 5 70
Invitae 0 0 39 16 11 66
Ambry Genetics 0 3 28 13 4 48
Illumina Clinical Services Laboratory,Illumina 0 0 35 7 0 42
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario 0 0 27 5 3 35
Blueprint Genetics, 0 1 8 1 0 10
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 5 0 1 6
Stanford Center for Inherited Cardiovascular Disease,Stanford University 0 0 6 0 0 6
OMIM 5 0 0 0 0 5
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease,Montreal Heart Institute 0 0 3 0 1 4
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 0 0 2 0 0 2
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 1 0 1 2
Division of Human Genetics,Children's Hospital of Philadelphia 0 0 2 0 0 2
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development,Heart and Diabetes Center North Rhine-Westphalia 0 1 1 0 0 2
PreventionGenetics 0 0 0 0 1 1
Fulgent Genetics 0 0 1 0 0 1
Center for Medical Genetics Ghent,University of Ghent 0 0 1 0 0 1
Agnes Ginges Centre for Molecular Cardiology,Centenary Institute 0 0 1 0 0 1
Soonchunhyang University Bucheon Hospital,Soonchunhyang University Medical Center 0 0 1 0 0 1
Bioscientia Institut fuer Medizinische Diagnostik GmbH,Sonic Healthcare 0 1 0 0 0 1
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 1 0 0 1

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