List of variants in gene POLE reported as benign by ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 34

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HGVS	dbSNP	gnomAD frequency
NM_006231.4(POLE):c.3582+17A>G	rs5744889	0.97472
NM_006231.4(POLE):c.6252A>G (p.Ser2084=)	rs5745022	0.66039
NM_006231.4(POLE):c.910-6G>C	rs4077170	0.64353
NM_006231.4(POLE):c.3156G>A (p.Thr1052=)	rs5744857	0.53577
NM_006231.4(POLE):c.4530A>G (p.Ala1510=)	rs5744944	0.53564
NM_006231.4(POLE):c.6330+15G>A	rs5745023	0.49667
NM_006231.4(POLE):c.6657+16C>T	rs5745075	0.34836
NM_006231.4(POLE):c.4187A>G (p.Asn1396Ser)	rs5744934	0.12807
NM_006231.4(POLE):c.4444+4T>A	rs5744941	0.05640
NM_006231.4(POLE):c.3379-5T>C	rs5744886	0.02670
NM_006231.4(POLE):c.3126G>A (p.Lys1042=)	rs5744856	0.02344
NM_006231.4(POLE):c.4290+5C>T	rs5744936	0.02053
NM_006231.4(POLE):c.2320-13A>G	rs75329753	0.01853
NM_006231.4(POLE):c.2550C>T (p.Ile850=)	rs5744834	0.01438
NM_006231.4(POLE):c.6418G>A (p.Glu2140Lys)	rs5745066	0.01416
NM_006231.4(POLE):c.5678+4C>T	rs5744973	0.01405
NM_006231.4(POLE):c.6330+18C>T	rs5745024	0.01405
NM_006231.4(POLE):c.91G>T (p.Ala31Ser)	rs34047482	0.01320
NM_006231.4(POLE):c.6330+19G>A	rs5745025	0.01268
NM_006231.4(POLE):c.2174-8G>A	rs117409343	0.01137
NM_006231.4(POLE):c.2928C>T (p.Arg976=)	rs5744845	0.00958
NM_006231.4(POLE):c.5583A>C (p.Ser1861=)	rs5744972	0.00949
NM_006231.4(POLE):c.5804G>A (p.Cys1935Tyr)	rs5744991	0.00898
NM_006231.4(POLE):c.6494G>A (p.Arg2165His)	rs5745068	0.00550
NM_006231.4(POLE):c.6763A>T (p.Ile2255Phe)	rs73155056	0.00513
NM_006231.4(POLE):c.1359+18C>T	rs5744775	0.00455
NM_006231.4(POLE):c.6817A>T (p.Thr2273Ser)	rs73481453	0.00444
NM_006231.4(POLE):c.2468+10C>T	rs5744823	0.00342
NM_006231.4(POLE):c.4259C>T (p.Ala1420Val)	rs41561818	0.00325
NM_006231.4(POLE):c.2083T>A (p.Phe695Ile)	rs5744799
NM_006231.4(POLE):c.2089C>T (p.Pro697Ser)	rs5744800
NM_006231.4(POLE):c.3275+12_3275+37del	rs1057517627
NM_006231.4(POLE):c.4552-10G>T	rs5744946
NM_006231.4(POLE):c.4952+17_4952+19dup	rs571641918

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