ClinVar Miner

Variants in gene RAD51C

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor total
75 60 462 240 21 7 786

Condition and significance breakdown #

Total conditions: 13
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor total
Hereditary cancer-predisposing syndrome 38 32 304 173 9 0 538
Fanconi anemia, complementation group O 51 28 273 69 8 0 424
not provided 19 18 108 11 7 0 158
not specified 0 0 31 89 17 0 129
Breast-ovarian cancer, familial 3 7 3 15 10 4 7 44
Breast-ovarian cancer, familial 3; Fanconi anemia, complementation group O 7 6 18 5 1 0 37
Hereditary breast and ovarian cancer syndrome 7 7 16 0 0 0 30
Breast and Ovarian Cancer Susceptibility 0 0 2 6 0 0 8
Fanconi anemia 0 0 2 6 0 0 8
Ovarian Neoplasms 6 2 0 0 0 0 8
RAD51C-Related Disorders 1 0 1 0 0 0 2
Familial cancer of breast 0 0 0 1 0 0 1
Premature ovarian insufficiency 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 29
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor total
Invitae 50 25 269 63 7 0 414
Ambry Genetics 33 27 220 81 5 0 366
Color 19 16 175 108 9 0 327
GeneDx 18 16 90 84 15 0 223
Counsyl 9 7 29 14 5 0 63
Integrated Genetics/Laboratory Corporation of America 5 3 44 0 6 0 58
Quest Diagnostics Nichols Institute San Juan Capistrano 2 2 20 6 6 0 34
PreventionGenetics 0 1 9 9 3 0 22
Mendelics 2 4 15 0 0 0 21
University of Washington Department of Laboratory Medicine,University of Washington 0 1 1 11 0 0 13
Illumina Clinical Services Laboratory,Illumina 1 0 3 6 0 0 10
OMIM 1 0 0 0 0 7 8
Fulgent Genetics 3 1 4 0 0 0 8
GeneKor MSA 1 1 5 1 0 0 8
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne 6 2 0 0 0 0 8
True Health Diagnostics 0 0 2 5 0 0 7
Genetic Services Laboratory, University of Chicago 1 0 2 0 1 0 4
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 2 0 2 0 4
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 2 2 0 0 4
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. 0 0 2 1 0 0 3
Baylor Miraca Genetics Laboratories, 0 2 0 0 0 0 2
Laboratoire de Biologie et Génétique du Cancer,Centre François Baclesse 2 0 0 0 0 0 2
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 0 0 0 0 1 0 1
Division of Human Genetics,Children's Hospital of Philadelphia 1 0 0 0 0 0 1
Center for Pediatric Genomic Medicine,Children's Mercy Hospital and Clinics 0 0 0 1 0 0 1
MVZ Praenatalmedizin und Genetik Nuernberg 0 0 0 1 0 0 1
Genomics Laboratory,Virgen de la Arrixaca University Clinical Hospital 0 0 1 0 0 0 1
Molecular Development Laboratory,Murdoch Childrens Research Institute 0 0 1 0 0 0 1
Department of Molecular Diagnostics,Institute of Oncology 1 0 0 0 0 0 1

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