ClinVar Miner

Variants in gene RAD51C

Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
139 88 727 338 21 8 2 1202

Condition and significance breakdown #

Total conditions: 24
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Fanconi anemia, complementation group O 98 53 537 136 8 0 0 816
Hereditary cancer-predisposing syndrome 51 39 424 224 8 0 0 719
not provided 31 25 124 51 6 0 0 222
not specified 1 0 39 106 18 0 0 153
Breast-ovarian cancer, familial 3 12 6 29 14 4 7 2 66
Hereditary breast and ovarian cancer syndrome 12 11 21 0 0 0 0 44
Breast-ovarian cancer, familial 3; Fanconi anemia, complementation group O 7 6 18 5 1 0 0 37
Malignant tumor of breast 3 0 10 4 4 0 0 21
Neoplasm of ovary 10 2 3 0 0 0 0 15
Breast and/or ovarian cancer 3 2 0 0 0 0 0 5
none provided 0 0 0 0 5 0 0 5
Breast and Ovarian Cancer Susceptibility 0 0 0 4 0 0 0 4
Fanconi anemia 0 0 0 4 0 0 0 4
Breast-ovarian cancer, familial 1 1 0 0 0 0 1 0 2
Carcinoma of colon 0 0 2 0 0 0 0 2
Familial cancer of breast 0 0 1 1 0 0 0 2
Hereditary site-specific ovarian cancer syndrome 2 0 0 0 0 0 0 2
RAD51C-Related Disorders 1 0 1 0 0 0 0 2
Endometrial carcinoma 0 0 1 0 0 0 0 1
Hereditary ovarian carcinoma 0 1 0 0 0 0 0 1
Mental retardation, X-linked 1 1 0 0 0 0 0 0 1
Microcephaly 0 0 1 0 0 0 0 1
Premature ovarian failure 0 1 0 0 0 0 0 1
Premature ovarian insufficiency 0 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 48
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Invitae 96 46 524 144 7 0 0 817
Ambry Genetics 43 29 311 108 5 0 0 496
Color Health, Inc 32 21 267 152 8 0 0 480
GeneDx 18 17 90 86 15 0 0 226
Integrated Genetics/Laboratory Corporation of America 11 7 48 13 8 0 0 87
Counsyl 9 7 29 14 5 0 0 63
Quest Diagnostics Nichols Institute San Juan Capistrano 6 3 35 8 6 0 0 56
Leiden Open Variation Database 18 3 20 11 0 0 0 52
Mendelics 2 6 19 13 1 0 0 41
Department of Pathology and Laboratory Medicine,Sinai Health System 7 1 14 4 5 0 0 31
PreventionGenetics, PreventionGenetics 0 1 9 9 3 0 0 22
Illumina Clinical Services Laboratory,Illumina 1 0 11 7 2 0 0 19
University of Washington Department of Laboratory Medicine, University of Washington 0 1 1 11 0 0 0 13
CeGaT Praxis fuer Humangenetik Tuebingen 3 1 4 2 0 0 0 10
Institute of Human Genetics, University of Leipzig Medical Center 5 0 3 1 0 0 0 9
OMIM 1 0 0 0 0 7 0 8
Fulgent Genetics,Fulgent Genetics 3 1 4 0 0 0 0 8
GeneKor MSA 1 1 5 1 0 0 0 8
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne 6 2 0 0 0 0 0 8
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 1 0 0 1 5 0 0 7
True Health Diagnostics 0 0 2 5 0 0 0 7
Cancer Genomics Group,Japanese Foundation For Cancer Research 0 1 5 0 0 0 0 6
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 1 4 0 0 0 0 0 5
CZECANCA consortium 3 2 0 0 0 0 0 5
Genetic Services Laboratory, University of Chicago 1 0 2 0 1 0 0 4
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 0 0 2 0 2 0 0 4
Baylor Genetics 0 2 1 0 0 0 0 3
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. 0 0 2 1 0 0 0 3
Centre for Mendelian Genomics,University Medical Centre Ljubljana 2 0 1 0 0 0 0 3
Department of Molecular Diagnostics, Institute of Oncology Ljubljana 2 1 0 0 0 0 0 3
Division of Medical Genetics, University of Washington 0 1 2 0 0 0 0 3
King Laboratory,University of Washington 2 0 0 0 0 0 0 2
Laboratoire de Biologie et Génétique du Cancer,Centre François Baclesse 2 0 0 0 0 0 0 2
GenomeConnect, ClinGen 0 0 0 0 0 0 2 2
Liquid Biopsy and Precision Medicine Group,Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research 1 0 0 0 0 1 0 2
Greenwood Genetic Center Diagnostic Laboratories,Greenwood Genetic Center 0 1 0 0 0 0 0 1
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics,Children's Hospital of Philadelphia 0 0 0 0 1 0 0 1
Clinical Genetics Karolinska University Hospital,Karolinska University Hospital 1 0 0 0 0 0 0 1
Division of Human Genetics,Children's Hospital of Philadelphia 1 0 0 0 0 0 0 1
Center for Pediatric Genomic Medicine,Children's Mercy Hospital and Clinics 0 0 0 1 0 0 0 1
MVZ Praenatalmedizin und Genetik Nuernberg 0 0 0 1 0 0 0 1
Genomics Laboratory,Virgen de la Arrixaca University Clinical Hospital 0 0 1 0 0 0 0 1
Reproductive Development, Murdoch Childrens Research Institute 0 0 1 0 0 0 0 1
Medical Cytogenetics and Molecular Genetics Laboratory,IRCCS Istituto Auxologico Italiano 0 1 0 0 0 0 0 1
UNC Molecular Genetics Laboratory,University of North Carolina at Chapel Hill 1 0 0 0 0 0 0 1
Department of Pediatrics, Samsung Medical Center, Samsung Medical Center 0 0 1 0 0 0 0 1
Molecular Oncology Research Center,Barretos Cancer Hospital 1 0 0 0 0 0 0 1
Swisher Lab, University of Washington 0 1 0 0 0 0 0 1

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