ClinVar Miner

Variants in gene RAD51C

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Gene type:
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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor total
90 66 541 286 21 7 926

Condition and significance breakdown #

Total conditions: 13
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor total
Hereditary cancer-predisposing syndrome 45 34 376 194 9 0 636
Fanconi anemia, complementation group O 61 36 336 35 5 0 466
not provided 20 22 109 97 8 0 249
not specified 1 0 29 92 17 0 131
Breast-ovarian cancer, familial 3 7 3 15 10 4 7 44
Breast-ovarian cancer, familial 3; Fanconi anemia, complementation group O 7 6 18 5 1 0 37
Hereditary breast and ovarian cancer syndrome 7 7 16 0 0 0 30
Breast and Ovarian Cancer Susceptibility 0 0 2 6 0 0 8
Fanconi anemia 0 0 2 6 0 0 8
Ovarian Neoplasms 6 2 0 0 0 0 8
RAD51C-Related Disorders 1 0 1 0 0 0 2
Familial cancer of breast 0 0 0 1 0 0 1
Premature ovarian insufficiency 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 30
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor total
Invitae 60 29 328 106 7 0 530
Ambry Genetics 42 29 313 107 5 0 496
Color 19 16 175 108 9 0 327
GeneDx 18 17 90 86 15 0 226
Counsyl 9 7 29 14 5 0 63
Integrated Genetics/Laboratory Corporation of America 5 4 38 5 6 0 58
Quest Diagnostics Nichols Institute San Juan Capistrano 5 4 29 7 6 0 49
Mendelics 2 6 19 13 1 0 41
PreventionGenetics,PreventionGenetics 0 1 9 9 3 0 22
University of Washington Department of Laboratory Medicine, University of Washington 0 1 1 11 0 0 13
Illumina Clinical Services Laboratory,Illumina 1 0 3 6 0 0 10
OMIM 1 0 0 0 0 7 8
Fulgent Genetics,Fulgent Genetics 3 1 4 0 0 0 8
GeneKor MSA 1 1 5 1 0 0 8
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne 6 2 0 0 0 0 8
True Health Diagnostics 0 0 2 5 0 0 7
CeGaT Praxis fuer Humangenetik Tuebingen 0 1 3 2 0 0 6
Genetic Services Laboratory, University of Chicago 1 0 2 0 1 0 4
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 2 0 2 0 4
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 1 0 0 1 1 0 3
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. 0 0 2 1 0 0 3
Baylor Genetics 0 2 0 0 0 0 2
Laboratoire de Biologie et Génétique du Cancer,Centre François Baclesse 2 0 0 0 0 0 2
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 0 0 0 0 1 0 1
Division of Human Genetics,Children's Hospital of Philadelphia 1 0 0 0 0 0 1
Center for Pediatric Genomic Medicine,Children's Mercy Hospital and Clinics 0 0 0 1 0 0 1
MVZ Praenatalmedizin und Genetik Nuernberg 0 0 0 1 0 0 1
Genomics Laboratory,Virgen de la Arrixaca University Clinical Hospital 0 0 1 0 0 0 1
Reproductive Development, Murdoch Childrens Research Institute 0 0 1 0 0 0 1
Department of Molecular Diagnostics,Institute of Oncology 1 0 0 0 0 0 1

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